2023
Evidence Accumulates: Patients with Ascending Aneurysms Are Strongly Protected from Atherosclerotic Disease
Waldron C, Zafar M, Ziganshin B, Weininger G, Grewal N, Elefteriades J. Evidence Accumulates: Patients with Ascending Aneurysms Are Strongly Protected from Atherosclerotic Disease. International Journal Of Molecular Sciences 2023, 24: 15640. PMID: 37958625, PMCID: PMC10650782, DOI: 10.3390/ijms242115640.Peer-Reviewed Original ResearchConceptsThoracic aortic aneurysmAortic aneurysmCarotid intima-media thicknessLow-density lipoprotein levelsIntima-media thicknessDevelopment of atherosclerosisMatrix metalloproteinase proteinsAscending aneurysmAortic calcificationAtherosclerotic diseaseLipoprotein levelsMyocardial infarctionLeading causeAneurysmsMetalloproteinase proteinsGrowth factorProtective relationshipDiseasePossible mechanismCurrent understandingMorbidityInfarctionAtherosclerosisPatientsPathophysiologyThe natural history of aortic root aneurysms
Ziganshin B, Kargin N, Zafar M, Elefteriades J. The natural history of aortic root aneurysms. Annals Of Cardiothoracic Surgery 2023, 12: 21324-21224. PMID: 37304695, PMCID: PMC10248916, DOI: 10.21037/acs-2023-avs1-20.Peer-Reviewed Original Research
2022
Rapid growth of thoracic aortic aneurysm: Reality or myth?
Sonsino A, Ellauzi H, Ziganshin BA, Zafar MA, Elefteriades JA. Rapid growth of thoracic aortic aneurysm: Reality or myth? Journal Of Thoracic And Cardiovascular Surgery 2022, 167: 1206-1213. PMID: 36028356, DOI: 10.1016/j.jtcvs.2022.06.021.Peer-Reviewed Original ResearchRapid aortic growthAortic growthAortic growth rateProphylactic surgical interventionThoracic aortic aneurysmPrompt surgeryInoperable patientsAortic diseaseSurgical interventionAortic measurementsAortic aneurysmPositivity ratePatientsAortaExperienced cliniciansGenetic findingsAortic imagesAneurysmsAmerican AssociationPotential sourceSurgeryAscendingCliniciansDiseaseSurvivorsAortic gene dictionary in the precision medicine era—update from the Aortic Institute at Yale New Haven
Papanikolaou D, Zafar MA, Ziganshin BA, Elefteriades JA. Aortic gene dictionary in the precision medicine era—update from the Aortic Institute at Yale New Haven. Indian Journal Of Thoracic And Cardiovascular Surgery 2022, 38: 14-23. PMID: 35463698, PMCID: PMC8980985, DOI: 10.1007/s12055-021-01308-9.Peer-Reviewed Original Research
2021
Ascending Aneurysms in Heart Transplant Patients A Rare Opportunity to Assess Heredity Versus Biological Environment
Anis O, Kopf G, Ziganshin B, Zafar M, Tranquilli M, Sieller R, Elefteriades J. Ascending Aneurysms in Heart Transplant Patients A Rare Opportunity to Assess Heredity Versus Biological Environment. JACC Case Reports 2021, 3: 1685-1689. PMID: 34766019, PMCID: PMC8571777, DOI: 10.1016/j.jaccas.2021.07.010.Peer-Reviewed Original ResearchDelayed Surgery for Acute Aortic Dissection
Pinkhasova P, Zafar M, Ziganshin B, Elefteriades J. Delayed Surgery for Acute Aortic Dissection. 2021, 535-551. DOI: 10.1007/978-3-030-66668-2_37.Peer-Reviewed Original ResearchSimple Hepatic Cysts as Markers of Thoracic Aortic Disease
C K, BA Z, MA Z, J B, J E. Simple Hepatic Cysts as Markers of Thoracic Aortic Disease. Journal Of Disease Markers 2021, 6 DOI: 10.26420/jdismarkers.2021.1043.Peer-Reviewed Original ResearchThoracic aortic diseaseSimple hepatic cystsBovine aortic archBicuspid aortic valveSimple renal cystsPositive family historyMost patientsAortic diseaseHepatic cystsRetrospective studyAortic aneurysmAortic archAortic valveClinical markersHospital patientsFamily historyRenal cystsTAD patientsControl groupPatientsAneurysmsPrevalenceCystsDisease
2020
The Genetics of Thoracic Aortic Aneurysms and Dissection: A Clinical Perspective
Ostberg NP, Zafar MA, Ziganshin BA, Elefteriades JA. The Genetics of Thoracic Aortic Aneurysms and Dissection: A Clinical Perspective. Biomolecules 2020, 10: 182. PMID: 31991693, PMCID: PMC7072177, DOI: 10.3390/biom10020182.Peer-Reviewed Original ResearchConceptsAortic aneurysmThoracic aortic aneurysmHigh mortality rateGenetic screening testsClinical manifestationsSurgical interventionNon-syndromic TAADHigh riskMortality rateClear genetic basisScreening testNatural historyClinical perspectiveTAADDegenerative diseasesDissectionCellular mechanismsBiomechanical stressPatientsAneurysmsDiseaseAortaExtensive investigation
2019
Fluoroquinolones and Aortic Diseases: Is There a Connection
Carino D, Zafar MA, Singh M, Ziganshin BA, Elefteriades JA. Fluoroquinolones and Aortic Diseases: Is There a Connection. Aorta 2019, 07: 035-041. PMID: 31529426, PMCID: PMC6748841, DOI: 10.1055/s-0039-1693468.Peer-Reviewed Original ResearchAortic diseaseAdverse effectsHigh tissue distributionThoracic aortic diseaseConsumption of fluoroquinolonesDifferent adverse effectsNumerous infectious diseasesAntibacterial coverageRetinal detachmentAortic aneurysmClasses of antibioticsInfectious diseasesDiseaseFluoroquinolonesTissue distributionCollagen degradationMolecular mechanismsPossible contributionDysglycemiaAneurysmsArrhythmiasPathogenesisDissectionAchillesSimple renal cysts and bovine aortic arch: markers for aortic disease
Brownstein AJ, Bin Mahmood SU, Saeyeldin A, Velasquez Mejia C, Zafar MA, Li Y, Rizzo JA, Dahl NK, Erben Y, Ziganshin BA, Elefteriades JA. Simple renal cysts and bovine aortic arch: markers for aortic disease. Open Heart 2019, 6: e000862. PMID: 30774963, PMCID: PMC6350752, DOI: 10.1136/openhrt-2018-000862.Peer-Reviewed Original ResearchBovine aortic archSimple renal cystsThoracic aortic diseaseAbdominal aortic aneurysmType B aortic dissectionB aortic dissectionAortic dissectionAortic aneurysmAortic diseaseAortic archRenal cystsChronic kidney diseasePresence of hypertensionAortic aneurysm developmentAbdominal CTMultivariable analysisKidney diseaseRetrospective searchPatientsAneurysm developmentAneurysmsPropensity scoreDiseaseDissectionPrevalence
2018
Chapter 3 Histology of Aortic Disease and Progression of Aortic Dissection From Acute to Chronic
Zafar M, Peterss S, Ziganshin B, Elefteriades J. Chapter 3 Histology of Aortic Disease and Progression of Aortic Dissection From Acute to Chronic. 2018, 41-59. DOI: 10.1016/b978-0-12-809979-7.00003-1.Peer-Reviewed Original ResearchChronic stateUncomplicated acute type B dissectionAcute type B dissectionAcute Stanford typeType B dissectionEarly surgical interventionTreatment of choiceChronic dissectionB dissectionStanford typeAortic dissectionMedical therapyAortic diseaseSurgical interventionDissectionAortaTemporal courseHistologyMorphological changesAcuteChronicHistopathologyTherapyDiseaseProgression
2017
Medical management of aortic disease in Marfan syndrome.
Bin Mahmood SU, Velasquez CA, Zafar MA, Saeyeldin AA, Brownstein AJ, Ziganshin BA, Elefteriades JA, Mukherjee SK. Medical management of aortic disease in Marfan syndrome. Annals Of Cardiothoracic Surgery 2017, 6: 654-661. PMID: 29270377, PMCID: PMC5721117, DOI: 10.21037/acs.2017.11.09.Peer-Reviewed Original ResearchAngiotensin receptor blockersMedical managementMarfan syndromeMFS patientsThoracic aortic aneurysm diseaseDifferent medical regimensStandard of careAortic aneurysm diseaseNumerous pathophysiological effectsAortic dilatationReceptor blockersAortic diseaseMedical regimensCurrent guidelinesAneurysm diseaseCardiovascular organsΒ-blockersCurrent evidencePathophysiological effectsHereditary disorderPatientsSyndromeDiseaseRegimensManagement