2024
Patient-specific ascending aortic intervention criteria
Kalogerakos P, Zafar M, Li Y, Ellauzi H, Mukherjee S, Ziganshin B, Rizzo J, Elefteriades J. Patient-specific ascending aortic intervention criteria. European Journal Of Cardio-Thoracic Surgery 2024, 65: ezae162. PMID: 38632077, DOI: 10.1093/ejcts/ezae162.Peer-Reviewed Original ResearchAdverse aortic eventsRisk of adverse eventsAortic eventsAortic rootAneurysm patientsAscending aortaAdverse eventsIncreased risk of adverse eventsThoracic aortic aneurysm patientsAscending aortic aneurysmHigher risk of adverse eventsAortic aneurysm patientsAscending thoracic aortic aneurysm patientsBody surface areaGeneral populationPersonalized risk stratificationAortic diameterAneurysm locationRisk stratificationAortic aneurysmIncreased riskAscending diameterPatientsHigh riskZ-score
2023
Midterm follow-up of composite graft replacement of the aortic root (30-year experience)—remarkably safe, effective, and durable
Jeoffrey S, Zafar M, Velasco J, Khattak A, Ellauzi H, Nasir A, Kalyanasundaram A, Ziganshin B, Elefteriades J. Midterm follow-up of composite graft replacement of the aortic root (30-year experience)—remarkably safe, effective, and durable. JTCVS Open 2023, 17: 1-13. PMID: 38420531, PMCID: PMC10897671, DOI: 10.1016/j.xjon.2023.11.007.Peer-Reviewed Original ResearchAortic root replacementOperative mortalityTerm outcomesDistal aortic segmentsLong-term bleedingAortic root diseaseComposite graft replacementType A DissectionFirst-time operationsAge/genderARR patientsConcomitant CABGLate reoperationAcute typeRoot replacementAdverse eventsGraft failureGraft replacementRedo proceduresCabrol procedureUrgent operationAortic rootAortic segmentsPatientsOperative choiceThe natural history of aortic root aneurysms
Ziganshin B, Kargin N, Zafar M, Elefteriades J. The natural history of aortic root aneurysms. Annals Of Cardiothoracic Surgery 2023, 12: 21324-21224. PMID: 37304695, PMCID: PMC10248916, DOI: 10.21037/acs-2023-avs1-20.Peer-Reviewed Original ResearchExtended law of laplace for measurement of the cloverleaf anatomy of the aortic root
Ban E, Kalogerakos P, Khosravi R, Ziganshin B, Ellauzi H, Ramachandra A, Zafar M, Humphrey J, Elefteriades J. Extended law of laplace for measurement of the cloverleaf anatomy of the aortic root. The International Journal Of Cardiovascular Imaging 2023, 39: 1345-1356. PMID: 37046157, PMCID: PMC10250276, DOI: 10.1007/s10554-023-02847-5.Peer-Reviewed Original ResearchConceptsAortic root
2022
Engineering analysis of aortic wall stress and root dilatation in the V-shape surgery for treatment of ascending aortic aneurysms
Dong H, Liu M, Qin T, Liang L, Ziganshin B, Ellauzi H, Zafar M, Jang S, Elefteriades J, Sun W. Engineering analysis of aortic wall stress and root dilatation in the V-shape surgery for treatment of ascending aortic aneurysms. Interdisciplinary CardioVascular And Thoracic Surgery 2022, 34: 1124-1131. PMID: 35134955, PMCID: PMC9159430, DOI: 10.1093/icvts/ivac004.Peer-Reviewed Original ResearchConceptsRoot dilatationAortic rootAortic wall stressAortic aneurysmWall stressComputed tomography imagesTime pointsAortic root diameterTomography imagesSignificant reductionPost-surgery statesWhole aortaAortic wallSurgeryDilatationClinical cardiacPatientsAverage dilatationStudy objectiveAneurysmsAortaBiomechanical analysisTreatmentProgress in surgical interventions for aortic root aneurysms and dissections
Parameswaran S, Ziganshin BA, Zafar M, Elefteriades JA. Progress in surgical interventions for aortic root aneurysms and dissections. Expert Review Of Cardiovascular Therapy 2022, 20: 65-79. PMID: 35037567, DOI: 10.1080/14779072.2022.2029702.Peer-Reviewed Original ResearchConceptsAortic root aneurysmRoot aneurysmAortic root replacement surgeryAortic root surgeryAortic valve leafletsValve dysfunctionAortic dissectionAortic pathologyProgressive dilatationSurgical optionsAneurysmal diseaseSurgical interventionCoronary arteryRoot surgeryAortic rootAortic tubeReplacement surgerySurgical investigationAnatomic patternsPubMed databaseRisk profileValve leafletsSystematic searchSurgeryAneurysms
2021
Root Dilatation Is More Malignant Than Ascending Aortic Dilation
Kalogerakos PD, Zafar MA, Li Y, Mukherjee SK, Ziganshin BA, Rizzo JA, Elefteriades JA. Root Dilatation Is More Malignant Than Ascending Aortic Dilation. Journal Of The American Heart Association 2021, 10: e020645. PMID: 34238012, PMCID: PMC8483477, DOI: 10.1161/jaha.120.020645.Peer-Reviewed Original ResearchConceptsMid-ascending aortaAortic rootAdverse eventsRoot dilatationNatural historyAcute aortic dissectionLong-term complicationsAortic root dilatationSignificant higher riskThoracic aortic aneurysmSerious risk factorAortic interventionAortic dilatationAortic dilationAortic dissectionAortic aneurysmInternational registryRisk factorsAortic segmentsGuideline criteriaHigh riskExpert centersAortaShort statureResult diametersFate of Preserved Aortic Root Following Acute Type A Aortic Dissection Repair
Ellauzi H, Zafar MA, Wu J, Papanikolaou D, Buntin J, Ziganshin BA, Elefteriades JA. Fate of Preserved Aortic Root Following Acute Type A Aortic Dissection Repair. Seminars In Thoracic And Cardiovascular Surgery 2021, 34: 419-427. PMID: 33979665, DOI: 10.1053/j.semtcvs.2021.04.002.Peer-Reviewed Original ResearchConceptsSevere aortic insufficiencyAortic insufficiencyAortic rootAcute typeAortic dissectionAortic replacementFree ruptureAdverse eventsAcute Type A Aortic Dissection RepairType A Aortic Dissection RepairProximal aortic suture lineSatisfactory long-term outcomeAortic dissection repairAortic root pseudoaneurysmAortic suture lineNon-reoperated patientsProximal aortic reoperationsAortic root diameterLong-term outcomesLong-term survivalAortic reoperationDissection repairOperative mortalityPrior surgeryOverall survival
2017
Natural history of aortic root aneurysms in Marfan syndrome.
Saeyeldin A, Zafar MA, Velasquez CA, Ip K, Gryaznov A, Brownstein AJ, Li Y, Rizzo JA, Erben Y, Ziganshin BA, Elefteriades JA. Natural history of aortic root aneurysms in Marfan syndrome. Annals Of Cardiothoracic Surgery 2017, 6: 625-632. PMID: 29270374, PMCID: PMC5721101, DOI: 10.21037/acs.2017.11.10.Peer-Reviewed Original ResearchAortic root aneurysmAortic root diameterAortic dissectionRoot aneurysmMFS patientsAortic complicationsAdverse eventsAortic rootNatural historyRisk of complicationsAortic root dilatationMarfan syndrome patientsLogistic regression modelsAortic regurgitationCardiovascular complicationsHemodynamic roleDreadful complicationRoot dilatationAortic diameterLarge aneurysmsSyndrome patientsMarfan syndromeComplicationsPatientsAneurysms
2012
Are Thromboembolic and Bleeding Complications a Drawback for Composite Aortic Root Replacement?
Zafar MA, Farkas EA, Javier A, Anderson M, Gilani O, Elefteriades JA. Are Thromboembolic and Bleeding Complications a Drawback for Composite Aortic Root Replacement? The Annals Of Thoracic Surgery 2012, 94: 737-743. PMID: 22626762, DOI: 10.1016/j.athoracsur.2012.04.007.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAnalysis of VarianceAortic ValveBioprosthesisCirculatory Arrest, Deep Hypothermia InducedCohort StudiesFemaleHeart Valve DiseasesHeart Valve ProsthesisHeart Valve Prosthesis ImplantationHospital MortalityHumansIncidenceKaplan-Meier EstimateMaleMiddle AgedPostoperative ComplicationsPostoperative HemorrhagePrognosisProportional Hazards ModelsRetrospective StudiesRisk AssessmentSafety ManagementSurvival AnalysisThromboembolismTreatment OutcomeUltrasonographyConceptsComposite aortic root replacementAortic root replacementComposite graft replacementAortic root reconstructionRoot replacementGraft replacementRoot reconstructionValve-preserving aortic root reconstructionSocial Security Death IndexSex-matched populationKaplan-Meier curvesMechanical valve conduitBleeding complicationsHospital mortalityDistal embolismLatest followAortic databaseBiologic conduitDeath IndexPatient interviewsMinimal morbidityAortic rootExcellent survivalNative valveValve conduits