Featured Publications
Bleeding avoidance strategies and percutaneous coronary intervention outcomes: A 10-year observation from a Japanese Multicenter Registry
Sawano M, Spertus J, Masoudi F, Rumsfeld J, Numasawa Y, Inohara T, Kennedy K, Ueda I, Miyata H, Fukuda K, Kohsaka S. Bleeding avoidance strategies and percutaneous coronary intervention outcomes: A 10-year observation from a Japanese Multicenter Registry. American Heart Journal 2021, 235: 113-124. PMID: 33472053, DOI: 10.1016/j.ahj.2021.01.010.Peer-Reviewed Original ResearchConceptsPercutaneous coronary interventionTransfemoral approachTransradial approachNational Cardiovascular Data Registry CathPCI RegistryVascular closure device usePercutaneous coronary intervention outcomesMultivariable logistic regression analysisClosure device useConsecutive PCI patientsJapanese multicenter registryAdjusted odds ratioLogistic regression analysisPCI patientsCathPCI RegistryCoronary interventionMulticenter registryBleeding rateJapanese patientsOdds ratioRisk scoreLower riskPatientsUS populationCathPCIJapanese population
2023
Long-term outcomes of periprocedural coronary dissection and perforation for patients undergoing percutaneous coronary intervention in a Japanese multicenter registry
Kuno T, Ohata T, Nakamaru R, Sawano M, Kodaira M, Numasawa Y, Ueda I, Suzuki M, Noma S, Fukuda K, Kohsaka S. Long-term outcomes of periprocedural coronary dissection and perforation for patients undergoing percutaneous coronary intervention in a Japanese multicenter registry. Scientific Reports 2023, 13: 20318. PMID: 37985895, PMCID: PMC10662469, DOI: 10.1038/s41598-023-47444-7.Peer-Reviewed Original ResearchConceptsPercutaneous coronary interventionLong-term outcomesCoronary dissectionPrimary endpointCoronary perforationCoronary interventionHeart failurePrimary outcomeMultivariable Cox hazards regression modelIndex percutaneous coronary interventionCox hazard regression modelPoor long-term outcomesIatrogenic coronary dissectionJapanese multicenter registryMulticenter prospective registryCoronary artery bypassAcute coronary syndromeHeart failure readmissionContrast medium extravasationHazards regression modelsPersistent filling defectSignificant differencesHigh rateCause deathArtery bypassOne‐year outcomes of patients undergoing percutaneous coronary intervention with the revived directional coronary atherectomy catheter: Insights from the J‐PCI OUTCOME registry
Numasawa Y, Sawano M, Ishii H, Kohsaka S, Kikuta Y, Matoba T, Amano T, Kozuma K, Investigators T. One‐year outcomes of patients undergoing percutaneous coronary intervention with the revived directional coronary atherectomy catheter: Insights from the J‐PCI OUTCOME registry. Catheterization And Cardiovascular Interventions 2023, 102: 1229-1237. PMID: 37943854, DOI: 10.1002/ccd.30895.Peer-Reviewed Original ResearchMeSH KeywordsAngina, UnstableAtherectomy, CoronaryCathetersCoronary Artery DiseaseFemaleHemorrhageHumansMalePercutaneous Coronary InterventionRegistriesTreatment OutcomeConceptsMajor adverse cardiovascular eventsDirectional coronary atherectomyPercutaneous coronary interventionStable coronary artery diseaseOne-year outcomesCoronary artery diseaseMajor bleedingCoronary interventionUnstable anginaArtery diseaseDCA groupContemporary real-world practiceDrug-coated balloon angioplastyOne-year clinical outcomesJapanese nationwide registryNonfatal major bleedingAdverse cardiovascular eventsCardiovascular deathCardiovascular eventsCause mortalityMidterm outcomesBaseline characteristicsCardiovascular mortalityCoronary atherectomyNationwide registryGender Differences in Long-Term Outcomes of Young Patients Who Underwent Percutaneous Coronary Intervention: Long-Term Outcome Analysis from a Multicenter Registry in Japan
Kuno T, Miyamoto Y, Sawano M, Kodaira M, Numasawa Y, Ueda I, Suzuki M, Noma S, Fukuda K, Kohsaka S. Gender Differences in Long-Term Outcomes of Young Patients Who Underwent Percutaneous Coronary Intervention: Long-Term Outcome Analysis from a Multicenter Registry in Japan. The American Journal Of Cardiology 2023, 206: 151-160. PMID: 37703680, DOI: 10.1016/j.amjcard.2023.08.106.Peer-Reviewed Original ResearchConceptsPercutaneous coronary interventionPrimary end pointLong-term outcomesYounger patientsCause deathCoronary interventionOlder patientsMale patientsAcute coronary syndrome casesPrimary end point ratesLong-term outcome analysisST-elevation myocardial infarctionEnd pointUnderwent Percutaneous Coronary InterventionWorse long-term outcomesYoung womenCoronary artery bypassAcute coronary syndromeConsecutive young patientsYoung female patientProportion of smokingNoncardiac deathArtery bypassCoronary syndromeMulticenter registryIschemic and Bleeding Outcomes in Patients Who Underwent Percutaneous Coronary Intervention With Chronic Kidney Disease or Dialysis (from a Japanese Nationwide Registry)
Tobe A, Sawano M, Kohsaka S, Ishii H, Tanaka A, Numasawa Y, Amano T, Nakamura M, Ikari Y, Murohara T. Ischemic and Bleeding Outcomes in Patients Who Underwent Percutaneous Coronary Intervention With Chronic Kidney Disease or Dialysis (from a Japanese Nationwide Registry). The American Journal Of Cardiology 2023, 195: 37-44. PMID: 37004333, DOI: 10.1016/j.amjcard.2023.02.027.Peer-Reviewed Original ResearchConceptsChronic kidney diseasePercutaneous coronary interventionPresence of CKDCKD stages 1Ischemic eventsAdjustment of covariatesHigh riskPCI registryCoronary interventionKidney diseaseNew-generation drug-eluting stent implantationDrug-eluting stent implantationUnderwent Percutaneous Coronary InterventionCKD stage 3Stage 1Bleeding eventsBleeding outcomesDialysis groupOral anticoagulantsCKD 3Renal functionStent implantationIncidence ratePatientsCare delivery
2022
Overview of in‐hospital outcomes in patients undergoing percutaneous coronary intervention with the revived directional coronary atherectomy
Numasawa Y, Inohara T, Ishii H, Yamaji K, Kohsaka S, Sawano M, Amano T, Nakamura M, Ikari Y, Investigators J. Overview of in‐hospital outcomes in patients undergoing percutaneous coronary intervention with the revived directional coronary atherectomy. Catheterization And Cardiovascular Interventions 2022, 100: 51-58. PMID: 35592940, DOI: 10.1002/ccd.30233.Peer-Reviewed Original ResearchMeSH KeywordsAngina, UnstableAtherectomy, CoronaryCoronary Artery DiseaseHospitalsHumansPercutaneous Coronary InterventionTreatment OutcomeConceptsStable coronary artery diseaseCoronary artery diseaseHospital outcomesUnstable anginaArtery diseaseDCA groupContemporary real-world practiceDrug-coated balloon angioplastyPercutaneous coronary intervention registryHospital adverse outcomesLeft main trunkChronic kidney diseaseDirectional coronary atherectomyPercutaneous coronary interventionCoronary Intervention RegistryLow complication rateTotal contrast volumePreferred treatment strategyPeriprocedural complicationsArtery lesionsBaseline characteristicsComplication rateCoronary atherectomyCoronary interventionIntervention Registry
2021
Contemporary Management of Stable Coronary Artery Disease ― Implications of the ISCHEMIA Trial ―
Kohsaka S, Fukushima K, Watanabe I, Manabe S, Niimi N, Gatate Y, Sawano M, Nakano S. Contemporary Management of Stable Coronary Artery Disease ― Implications of the ISCHEMIA Trial ―. Circulation Journal 2021, 85: 1919-1927. PMID: 34148929, DOI: 10.1253/circj.cj-21-0345.Peer-Reviewed Original ResearchMeSH KeywordsAcute Coronary SyndromeClinical Trials as TopicCoronary AngiographyCoronary Artery DiseaseHumansIschemiaConceptsCoronary artery diseaseAcute coronary syndromeStable coronary artery diseaseRecent large-scale clinical trialsLarge-scale clinical trialsCornerstone of managementInvasive coronary angiographyDifferent clinical entitiesUrgent revascularizationCoronary syndromeArtery diseaseCoronary angiographyMedical therapyISCHEMIA trialClinical entityClinical trialsDiagnostic pathwayLeading causePretest probabilityContemporary managementOptimal timingRevascularizationTrialsDisease implicationsMorbidity
2020
Beta blockers versus calcium channel blockers for provocation of vasospastic angina after drug-eluting stent implantation: a multicentre prospective randomised trial
Sawano M, Katsuki T, Kitai T, Tamita K, Obunai K, Ikegami Y, Yamane T, Ueda I, Endo A, Maekawa Y, Kawamura A, Fukuda K, Kohsaka S. Beta blockers versus calcium channel blockers for provocation of vasospastic angina after drug-eluting stent implantation: a multicentre prospective randomised trial. Open Heart 2020, 7: e001406. PMID: 33087441, PMCID: PMC7580072, DOI: 10.1136/openhrt-2020-001406.Peer-Reviewed Original ResearchMeSH KeywordsAdrenergic beta-AntagonistsAgedAged, 80 and overAngina PectorisCalcium Channel BlockersCoronary Artery DiseaseCoronary VasospasmDrug-Eluting StentsFemaleHumansIncidenceJapanMaleMiddle AgedPercutaneous Coronary InterventionProspective StudiesProtective FactorsRisk AssessmentRisk FactorsTime FactorsTreatment OutcomeConceptsMajor cardiovascular eventsPercutaneous coronary interventionCalcium channel blockersCoronary artery diseaseStable coronary artery diseaseDrug-eluting stent implantationAcetylcholine provocation testingDiagnostic coronary angiographyBeta blockersCCB groupArtery diseaseCoronary angiographyVasospastic anginaCoronary revascularisationProvocation testingStent implantationChannel blockersSecond-generation drug-eluting stent implantationUniversity Hospital Medical Information Network Clinical Trials RegistryIndex percutaneous coronary interventionNon-fatal myocardial infarctionSingle-vessel lesionsSubsequent coronary eventsCoronary artery spasmClinical Trials RegistryAssociation of decreasing hemoglobin levels with the incidence of acute kidney injury after percutaneous coronary intervention: a prospective multi-center study
Kuno T, Numasawa Y, Mikami T, Niimi N, Sawano M, Kodaira M, Suzuki M, Ueno K, Ueda I, Fukuda K, Kohsaka S. Association of decreasing hemoglobin levels with the incidence of acute kidney injury after percutaneous coronary intervention: a prospective multi-center study. Heart And Vessels 2020, 36: 330-336. PMID: 33034713, DOI: 10.1007/s00380-020-01706-w.Peer-Reviewed Original ResearchConceptsAcute kidney injuryPercutaneous coronary interventionRisk of AKIHemoglobin dropAKI incidenceKidney injuryCoronary interventionHemoglobin levelsProspective multi-center studySerum creatinine levelsMulti-center studyRelative decreaseConsecutive patientsCreatinine levelsIndependent predictorsRisk factorsHemoglobin changeHigh riskAbsolute decreaseLogistic regressionPatientsIncidenceHemoglobinInjuryDl
2019
In-hospital outcome in patients presenting with acute coronary syndrome with left main coronary artery disease: A report from Japanese prospective multicenter percutaneous coronary intervention registry
Tani H, Sawano M, Numasawa Y, Kobayashi Y, Suzuki M, Noma S, Shiraishi Y, Ueda I, Fukuda K, Kohsaka S. In-hospital outcome in patients presenting with acute coronary syndrome with left main coronary artery disease: A report from Japanese prospective multicenter percutaneous coronary intervention registry. Journal Of Cardiology 2019, 75: 635-640. PMID: 31899113, DOI: 10.1016/j.jjcc.2019.11.006.Peer-Reviewed Original ResearchConceptsAcute coronary syndromePercutaneous coronary interventionCardiogenic shockMortality rateACS patientsHospital mortalityCoronary syndromeHospital outcomesHigh riskLeft main coronary artery diseaseMain coronary artery diseasePresence of CSST-elevation myocardial infarctionPercutaneous coronary intervention registryContemporary risk modelsCoronary lesion characteristicsLeft main diseaseCoronary artery bypassHospital mortality rateDe novo patientsElevation myocardial infarctionCoronary artery diseaseCoronary Intervention RegistryShort-term outcomesKey clinical characteristicsReal-world use of intravascular ultrasound in Japan: a report from contemporary multicenter PCI registry
Kuno T, Numasawa Y, Sawano M, Abe T, Ueda I, Kodaira M, Suzuki M, Noma S, Nakamura I, Negishi K, Ishikawa S, Fukuda K, Kohsaka S. Real-world use of intravascular ultrasound in Japan: a report from contemporary multicenter PCI registry. Heart And Vessels 2019, 34: 1728-1739. PMID: 31129872, DOI: 10.1007/s00380-019-01427-9.Peer-Reviewed Original ResearchConceptsElective percutaneous coronary interventionPercutaneous coronary interventionEmergent percutaneous coronary interventionNon-IVUS groupPCI-related complicationsCoronary dissectionIntravascular ultrasoundIVUS usePCI registryMultivariate logistic regression analysisPlain old balloon angioplastyElective PCI patientsJapanese PCI registryMulticenter PCI registrySevere coronary dissectionMore comorbid conditionsClinical trial dataLogistic regression analysisLow event ratesIVUS groupPCI patientsCoronary interventionConsecutive patientsIndependent predictorsClinical outcomesComparison of Outcomes After Percutaneous Coronary Intervention in Elderly Patients, Including 10 628 Nonagenarians: Insights From a Japanese Nationwide Registry (J‐PCI Registry)
Numasawa Y, Inohara T, Ishii H, Yamaji K, Kohsaka S, Sawano M, Kodaira M, Uemura S, Kadota K, Amano T, Nakamura M, Kadota K, Shiode N, Tanaka N, Amano T, Uemura S, Akasaka T, Morino Y, Fujii K, Hikichi H, Kohsaka S, Ishii H, Tanabe K, Ozaki Y, Sumitsuji S, Iida O, Hara H, Takashima H, Shirai S, Nanasato M, Inohara T, Ueda Y, Numasawa Y, Noma S. Comparison of Outcomes After Percutaneous Coronary Intervention in Elderly Patients, Including 10 628 Nonagenarians: Insights From a Japanese Nationwide Registry (J‐PCI Registry). Journal Of The American Heart Association 2019, 8: e011183. PMID: 30791799, PMCID: PMC6474917, DOI: 10.1161/jaha.118.011017.Peer-Reviewed Original ResearchConceptsPercutaneous coronary interventionAcute coronary syndromeOlder patientsHospital mortalityElderly patientsCoronary interventionNationwide registryYounger patientsTransradial interventionStable coronary artery diseaseConclusion Older patientsJapanese nationwide registryProspective nationwide registryChronic kidney diseaseCoronary artery diseaseComparison of outcomesYears of ageCardiac tamponadeCardiogenic shockCoronary syndromeHospital deathHospital outcomesPeriprocedural complicationsArtery diseaseBlood transfusion
2018
An overview of percutaneous coronary intervention in dialysis patients: Insights from a Japanese nationwide registry
Numasawa Y, Inohara T, Ishii H, Yamaji K, Hirano K, Kohsaka S, Sawano M, Kuno T, Kodaira M, Uemura S, Kadota K, Amano T, Nakamura M, Investigators O. An overview of percutaneous coronary intervention in dialysis patients: Insights from a Japanese nationwide registry. Catheterization And Cardiovascular Interventions 2018, 94: e1-e8. PMID: 30467967, DOI: 10.1002/ccd.27986.Peer-Reviewed Original ResearchConceptsPercutaneous coronary interventionJapanese nationwide registryDialysis patientsHospital mortalityNondialysis patientsCoronary interventionNationwide registryACS cohortHeart failureAdverse outcomesAcute heart failureMore comorbiditiesCardiogenic shockHospital outcomesBlood transfusionClinical trialsFemale genderPCI casesPatientsJapanese hospitalsGreater riskMortalityComplicationsRegistryRisk
2017
Patterns of statin non-prescription in patients with established coronary artery disease: A report from a contemporary multicenter Japanese PCI registry
Sawano M, Kohsaka S, Abe T, Inohara T, Maekawa Y, Ueda I, Sueyoshi K, Suzuki M, Noma S, Numasawa Y, Miyata H, Fukuda K, Smolderen KG, Spertus JA. Patterns of statin non-prescription in patients with established coronary artery disease: A report from a contemporary multicenter Japanese PCI registry. PLOS ONE 2017, 12: e0182687. PMID: 28817616, PMCID: PMC5560610, DOI: 10.1371/journal.pone.0182687.Peer-Reviewed Original ResearchConceptsChronic kidney diseaseCoronary artery diseasePCI patientsStatin therapyArtery diseaseKidney diseaseHierarchical multivariable logistic regression analysisMultivariable logistic regression analysisPercutaneous coronary intervention registryJapanese PCI registryStatin prescription patternsCoronary Intervention RegistryLow-intensity statinsLogistic regression analysisCardiovascular eventsPCI registryIntervention RegistryPatient characteristicsPrescription patternsReal-world practiceStudy registryEffective medicationsHigh riskPatientsHigher age
2016
Use of renin-angiotensin system inhibitors after coronary interventions in patients with the guideline-based indications: A report from a Japanese multicenter registry
Ikemura N, Sawano M, Miyata H, Ueda I, Numasawa Y, Noma S, Suzuki M, Momiyama Y, Maekawa Y, Fukuda K, Kohsaka S. Use of renin-angiotensin system inhibitors after coronary interventions in patients with the guideline-based indications: A report from a Japanese multicenter registry. International Journal Of Cardiology 2016, 225: 362-364. PMID: 27756042, DOI: 10.1016/j.ijcard.2016.09.083.Peer-Reviewed Original Research