TNF-alpha and IL-8: Serum levels and gene polymorphisms (−308G>A and −251A>T) are associated with classical biomarkers and medical history in children with sickle cell anemia
Cajado C, Cerqueira B, Couto F, Moura-Neto J, Vilas-Boas W, Dorea M, Lyra I, Barbosa C, Reis M, Goncalves M. TNF-alpha and IL-8: Serum levels and gene polymorphisms (−308G>A and −251A>T) are associated with classical biomarkers and medical history in children with sickle cell anemia. Cytokine 2011, 56: 312-317. PMID: 21802960, DOI: 10.1016/j.cyto.2011.07.002.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAllelesAnemia, Sickle CellBiomarkersCase-Control StudiesChildChild, PreschoolCross-Sectional StudiesEnzyme-Linked Immunosorbent AssayHaplotypesHumansInterleukin-8Medical History TakingPolymerase Chain ReactionPolymorphism, GeneticPolymorphism, Restriction Fragment LengthTumor Necrosis Factor-alphaConceptsSickle cell anemiaTNF-alpha -308GT gene polymorphismGene polymorphismsIL-8Serum levelsMedical historyTNF-alphaCell anemiaHigher TNF-alpha levelsIL-8 gene polymorphismsA alleleClassical biomarkersSteady-state sickle cell anemiaTNF-alpha levelsHeterogeneous clinical outcomesLogistic regression analysisYears of ageCytokine levelsClinical outcomesImmunological biomarkersHealthy controlsPatient outcomesInterleukin-8SCA patients