2017
Identification of distinctive patterns in cell signaling pathways in glioblastoma multiforme subtypes using gene expression TCGA data sets.
Volyanskyy K, Zhong M, Keswarpu P, Fallon J, Fanucchi M, Dimitrova N. Identification of distinctive patterns in cell signaling pathways in glioblastoma multiforme subtypes using gene expression TCGA data sets. Journal Of Clinical Oncology 2017, 35: e23162-e23162. DOI: 10.1200/jco.2017.35.15_suppl.e23162.Peer-Reviewed Original ResearchGene expression profilesPredictive genesCancer Genome AtlasG-CIMPTranscriptomic patternsRNAseq dataJAK-STATExpression profilesPathway interactionsBiological pathwaysNormal tissuesPI3K-AktCalcium signalingGenesGBM subtypesGene selectionGenome AtlasPotential therapeutic targetTCGA data setsPathwayPathway involvementTumor progressionTherapeutic targetDetected interactionsSubtype differentiation
2006
Phospholipase D1 corrects impaired βAPP trafficking and neurite outgrowth in familial Alzheimer’s disease-linked presenilin-1 mutant neurons
Cai D, Zhong M, Wang R, Netzer WJ, Shields D, Zheng H, Sisodia SS, Foster DA, Gorelick FS, Xu H, Greengard P. Phospholipase D1 corrects impaired βAPP trafficking and neurite outgrowth in familial Alzheimer’s disease-linked presenilin-1 mutant neurons. Proceedings Of The National Academy Of Sciences Of The United States Of America 2006, 103: 1936-1940. PMID: 16449385, PMCID: PMC1413666, DOI: 10.1073/pnas.0510710103.Peer-Reviewed Original ResearchConceptsTrans-Golgi networkOverexpression of PLD1Mutant neuronsPhospholipase D1Beta-amyloid precursor proteinIntracellular traffickingPS1-deficient cellsPLD enzymatic activityTherapeutic targetNeuronal functionPS1 mutationsOverexpression of WTBetaAPPPrecursor proteinMutant cellsSubcellular localizationNeurite outgrowthPLD1 activitySurface deliveryNeuronsOutgrowth capacityCellsTraffickingEnzymatic activityOverexpression