2023
NLRX1 knockdown attenuates pro-apoptotic signaling and cell death in pulmonary hyperoxic acute injury
Kim H, Kim M, Kim E, Leem J, Baek S, Lee Y, Kim K, Kang M, Song T, Sohn M. NLRX1 knockdown attenuates pro-apoptotic signaling and cell death in pulmonary hyperoxic acute injury. Scientific Reports 2023, 13: 3441. PMID: 36859435, PMCID: PMC9975446, DOI: 10.1038/s41598-023-28206-x.Peer-Reviewed Original ResearchConceptsHyperoxic acute lung injuryAcute lung injuryLung injuryWT miceAcute respiratory failurePro-inflammatory cytokinesCell deathRespiratory failureAcute injuryInflammatory cellsReduced mortalityRole of NLRX1Murine modelNLRX1 expressionPro-apoptotic signalingCell cytotoxicityHyperoxiaInjuryMiceProtein leakageHyperoxic conditionsNLRX1Apoptotic cell deathERK 1/2Reactive oxygen species
2001
The Increased Expression of Gelatinolytic Proteases Due to Gigarette Smoking Exposure in the Lung of Guinea Pig
Kang M, Lee J, Yoo C, Lee G, Chung H, Seo J, Kim Y, Han S, Shim Y. The Increased Expression of Gelatinolytic Proteases Due to Gigarette Smoking Exposure in the Lung of Guinea Pig. Tuberculosis And Respiratory Diseases 2001, 50: 426-436. DOI: 10.4046/trd.2001.50.4.426.Peer-Reviewed Original ResearchPathogenesis of COPDInflammatory cellular infiltrationIntraalveolar cellsCS exposureGuinea pigsCellular infiltrationLung parenchymeHistologic changesAlveolar wallsGelatinolytic enzymesAlveolar inflammatory cellsBAL fluid cellsDuration of CSDays/weekHours/daySmoking exposureBAL fluidInflammatory cellsLung parenchymaWeek groupMMP expressionGelatin zymographyControl groupAdult populationDestructive changes