2020
Retrograde signaling by a mtDNA-encoded non-coding RNA preserves mitochondrial bioenergetics
Blumental-Perry A, Jobava R, Bederman I, Degar A, Kenche H, Guan B, Pandit K, Perry N, Molyneaux N, Wu J, Prendergas E, Ye Z, Zhang J, Nelson C, Ahangari F, Krokowski D, Guttentag S, Linden P, Townsend D, Miron A, Kang M, Kaminski N, Perry Y, Hatzoglou M. Retrograde signaling by a mtDNA-encoded non-coding RNA preserves mitochondrial bioenergetics. Communications Biology 2020, 3: 626. PMID: 33127975, PMCID: PMC7603330, DOI: 10.1038/s42003-020-01322-4.Peer-Reviewed Original ResearchConceptsMitochondrial genomeNuclear-encoded genesCell type-specific mannerNon-coding RNASteady-state transcriptionMitochondrial energy metabolismControl regionPositive regulationMitochondrial bioenergeticsMitochondria stressMitochondrial functionSpecific mannerAlveolar epithelial type II cellsEnergy metabolismType II cellsEpithelial type II cellsGenomePhysiological stressRNAII cellsCellsMouse lungTranscriptionGenesMitochondria
1995
Role of Oxygen Free Radical in the Expression of Interleukin-8 andInterleukin-1beta Gene in Mononuclear Phagocytic Cells
Kang M, Kim J, Park J, Lee S, Yoo C, Kim Y, Han S, Shim Y. Role of Oxygen Free Radical in the Expression of Interleukin-8 andInterleukin-1beta Gene in Mononuclear Phagocytic Cells. Tuberculosis And Respiratory Diseases 1995, 42: 862-870. DOI: 10.4046/trd.1995.42.6.862.Peer-Reviewed Original ResearchNorthern blot analysisActivation of NFkappaBIntracellular signal transduction pathwaysIL-1beta geneSignal transduction pathwaysBlot analysisMononuclear phagocytic cellsTranscription factor NFkappaBPhagocytic cellsActivation of NFkappaB.Extracellular stimuliTransduction pathwaysCytoplasmic formMild oxidant stressSecondary messengersProtein subunitsDependent expressionGenesCell typesTime-dependent expressionExogenous H2O2MRNA expressionPhorbol esterNFkappaBLPS stimulation