Imaging of I2-imidazoline receptors by small-animal PET using 2-(3-fluoro-[4-11C]tolyl)-4,5-dihydro-1H-imidazole ([11C]FTIMD)
Kawamura K, Naganawa M, Konno F, Yui J, Wakizaka H, Yamasaki T, Yanamoto K, Hatori A, Takei M, Yoshida Y, Sakaguchi K, Fukumura T, Kimura Y, Zhang MR. Imaging of I2-imidazoline receptors by small-animal PET using 2-(3-fluoro-[4-11C]tolyl)-4,5-dihydro-1H-imidazole ([11C]FTIMD). Nuclear Medicine And Biology 2010, 37: 625-635. PMID: 20610167, DOI: 10.1016/j.nucmedbio.2010.02.013.Peer-Reviewed Original ResearchConceptsImidazoline receptorsI2-imidazoline receptorsDynamic PET scansRat brainParkinson's diseasePositron emission tomography (PET) probesPET scansAlzheimer's diseaseBrain regionsBrain tissueDistinct receptorsTissue dissectionPET studiesDiseaseHuntington's diseaseTributylstannyl precursorSmall-animal PETBrainReceptorsFirst imagingPET probeSignificant reductionRadioactivity levelsRatsInjection