W15. A MULTIVARIATE GENOMIC INVESTIGATION OF THE EXTERNALIZING SPECTRUM AND SUICIDE RISK
Barr P, Bigdeli T, Sanchez-Roige S, Mallard T, Ashley-Koch A, Dick D, Harden P, Hauser B, Qin X, Aslan M, Harvey P, Beckham J, Kimbrel N. W15. A MULTIVARIATE GENOMIC INVESTIGATION OF THE EXTERNALIZING SPECTRUM AND SUICIDE RISK. European Neuropsychopharmacology 2024, 87: 108. DOI: 10.1016/j.euroneuro.2024.08.224.Peer-Reviewed Original ResearchSuicide attemptsSuicidal ideationPolygenic scoresAssociated with suicide attemptsGenomic structural equation modelingLifetime suicide riskRisk factors associated with suicideExternalizing polygenic scoresLifetime suicide attemptsSubstance use disordersFactors associated with suicideSubstance-use behaviorsExternalizing spectrumExternalizing disordersBipolar disorderPsychiatric diagnosisSuicide riskStructural equation modelingResults Preliminary resultsSuicidal phenotypeGenome-wide association studiesPersonality indicesIdeationSuicideCohort of veteransCorrelates of suicidal behaviors and genetic risk among United States veterans with schizophrenia or bipolar I disorder
Bigdeli T, Barr P, Rajeevan N, Graham D, Li Y, Meyers J, Gorman B, Peterson R, Sayward F, Radhakrishnan K, Natarajan S, Nielsen D, Wilkinson A, Malhotra A, Zhao H, Brophy M, Shi Y, O’Leary T, Gleason T, Przygodzki R, Pyarajan S, Muralidhar S, Gaziano J, Huang G, Concato J, Siever L, DeLisi L, Kimbrel N, Beckham J, Swann A, Kosten T, Fanous A, Aslan M, Harvey P. Correlates of suicidal behaviors and genetic risk among United States veterans with schizophrenia or bipolar I disorder. Molecular Psychiatry 2024, 29: 2399-2407. PMID: 38491344, DOI: 10.1038/s41380-024-02472-1.Peer-Reviewed Original ResearchBipolar I disorderSuicidal behaviorElectronic health recordsPolygenic scoresVeterans Health AdministrationSelf-reported SBColumbia-Suicide Severity Rating ScaleBipolar I disorder patientsCorrelates of suicidal behaviorClasses of psychotropic medicationsSelf-injurious behaviorHealth recordsSeverity Rating ScaleDiagnosed mental illnessAssociated with clinical variablesElectronic health record codesEHR domainDepressive disorderC-SSRSLifetime diagnosisSubstance-relatedPsychotropic medicationsSuicidal ideationExternalizing behaviorsSuicide attempts