2024
32. Comparative Genetic Architectures of Schizophrenia in Admixed African American and European Populations
Bigdeli T, Chatzinakos C, Voloudakis G, Gorman B, Barr P, Genovese G, Burstein D, Braff D, Gaziano J, Muralidhar S, Huang G, Pyarajan S, 572 C, Program M, Aslan M, Harvey P, Roussos P. 32. Comparative Genetic Architectures of Schizophrenia in Admixed African American and European Populations. Biological Psychiatry 2024, 95: s88. DOI: 10.1016/j.biopsych.2024.02.210.Peer-Reviewed Original Research
2023
88. GENETIC ARCHITECTURE OF SCHIZOPHRENIA IN AFRICAN ANCESTRY INDIVIDUALS
Bigdeli T, Gorman B, Voloudakis G, Chatzinakos C, Barr P, Burstein D, Genovese G, Pyarajan S, Huang G, Pato C, Pato M, Fanous A, Aslan M, Harvey P, Roussos P. 88. GENETIC ARCHITECTURE OF SCHIZOPHRENIA IN AFRICAN ANCESTRY INDIVIDUALS. European Neuropsychopharmacology 2023, 75: s103. DOI: 10.1016/j.euroneuro.2023.08.191.Peer-Reviewed Original ResearchAfrican ancestry individualsAllelic effectsMillion Veteran ProgramFine-mapping resolutionGenome-wide significanceNew biological insightsDuplication eventsGenetic architectureGenomic methodologiesAncestry tractsIndex SNPsSingle locusPhenotypic dataGenetic analysisBiological insightsMHC lociAfrican diaspora populationsAfrican ancestryLociChromosome 6p21Genetic effectsGenetic researchEast Asian populationsLarge-scale research initiativesHuman population
2021
Bi-ancestral depression GWAS in the Million Veteran Program and meta-analysis in >1.2 million individuals highlight new therapeutic directions
Levey DF, Stein MB, Wendt FR, Pathak GA, Zhou H, Aslan M, Quaden R, Harrington KM, Nuñez YZ, Overstreet C, Radhakrishnan K, Sanacora G, McIntosh AM, Shi J, Shringarpure SS, Concato J, Polimanti R, Gelernter J. Bi-ancestral depression GWAS in the Million Veteran Program and meta-analysis in >1.2 million individuals highlight new therapeutic directions. Nature Neuroscience 2021, 24: 954-963. PMID: 34045744, PMCID: PMC8404304, DOI: 10.1038/s41593-021-00860-2.Peer-Reviewed Original ResearchConceptsTranscriptome-wide association studyMillion Veteran ProgramTranscriptome-wide association study (TWAS) analysisGenomic risk lociComplex psychiatric traitsGenetic architectureRisk lociGene expressionAssociation studiesLikely pathogenicityPsychiatric traitsVeteran ProgramNew therapeutic directionEuropean ancestryNew insightsAncestryUK BiobankAfrican ancestrySubstantial replicationExpressionLarge independent cohortsGWASTherapeutic directionsGenesLoci
2020
Reproducible Genetic Risk Loci for Anxiety: Results From ∼200,000 Participants in the Million Veteran Program
Levey DF, Gelernter J, Polimanti R, Zhou H, Cheng Z, Aslan M, Quaden R, Concato J, Radhakrishnan K, Bryois J, Sullivan PF, Stein M. Reproducible Genetic Risk Loci for Anxiety: Results From ∼200,000 Participants in the Million Veteran Program. American Journal Of Psychiatry 2020, 177: 223-232. PMID: 31906708, PMCID: PMC7869502, DOI: 10.1176/appi.ajp.2019.19030256.Peer-Reviewed Original ResearchConceptsNovel genome-wide significant associationsGene expressionGenome-wide significant signalsGenome-wide significant associationMillion Veteran ProgramWide association studyGenetic risk lociSignificant genetic correlationsGenetic risk mechanismsGenetic architectureGlobal regulatorChromosome 3Risk lociChromosome 6Chromosome 7Association studiesLargest GWASLarge biobanksGlobal regulationGenetic correlationsContinuous traitsVeteran ProgramGWASsLociPrevious GWASs