2024
Daily glucose variability is associated with intrahepatic fat content, β cell sensitivity, and biomarkers of glycolysis in youth with obesity
Barbieri E, Bonet J, Fox D, Nelson R, Nelson M, Nelson L, Fernandez C, Van Name M, Samuels S, Caprio S, Sabati M, Galderisi A, Sherr J, Man C, Santoro N. Daily glucose variability is associated with intrahepatic fat content, β cell sensitivity, and biomarkers of glycolysis in youth with obesity. Obesity 2024, 33: 116-124. PMID: 39658509, PMCID: PMC11666407, DOI: 10.1002/oby.24175.Peer-Reviewed Original ResearchConceptsIntrahepatic fat contentDaily glucose variabilityLiver proton density fat fractionProton density fat fractionGlucose variabilityInsulin sensitivityOral glucose tolerance testFat fractionInsulin secretionAssociated with insulin resistanceFirst-phase insulin secretionAssociated with 2-h glucoseGlucose tolerance testGlucose standard deviationMagnetic resonance imagingOral minimal modelCoefficient of variationBasal insulin secretionPediatric obesityPostprandial glucoseTolerance testCell sensitivityInsulin resistanceObesityResonance imaging
2015
Hepatic De Novo Lipogenesis in Obese Youth Is Modulated by a Common Variant in the GCKR Gene
Santoro N, Caprio S, Pierpont B, Van Name M, Savoye M, Parks EJ. Hepatic De Novo Lipogenesis in Obese Youth Is Modulated by a Common Variant in the GCKR Gene. The Journal Of Clinical Endocrinology & Metabolism 2015, 100: e1125-e1132. PMID: 26043229, PMCID: PMC4524990, DOI: 10.1210/jc.2015-1587.Peer-Reviewed Original ResearchConceptsHepatic de novo lipogenesisDe novo lipogenesisFractional de novo lipogenesisCC subjectsNovo lipogenesisLiver lipid synthesisLow-density lipoproteinCarbohydrate drinkGlucose oxidationObese adolescentsObese youthTT subjectsTT genotypeCHO loadHigh basal ratesStudy aimRisk allelesGCKR geneLipogenesisGene variantsBasal rateCommon variantsSubjectsLipid synthesisLower increase