2021
Analysis of the Applicability of microRNAs in Peripheral Blood Leukocytes as Biomarkers of Sensitivity and Exposure to Fractionated Radiotherapy towards Breast Cancer
Marczyk M, Polańska J, Wojcik A, Lundholm L. Analysis of the Applicability of microRNAs in Peripheral Blood Leukocytes as Biomarkers of Sensitivity and Exposure to Fractionated Radiotherapy towards Breast Cancer. International Journal Of Molecular Sciences 2021, 22: 8705. PMID: 34445424, PMCID: PMC8395710, DOI: 10.3390/ijms22168705.Peer-Reviewed Original ResearchConceptsBreast cancer patientsExternal beam radiotherapyCourse of radiotherapyPeripheral blood leukocytesBiomarkers of sensitivityLogistic regression modelsMultinomial logistic regression modelsFractionated RadiotherapyInter-individual variabilityCancer patientsUnivariate analysisBreast cancerCombination of miRNAsBeam radiotherapyBlood leukocytesBlood samplesPromising biomarkerTotal doseSensitive biomarkerRadiotherapyPatientsStrong inter-individual variabilityBiomarkersDoseLeukocytes
2016
Serum mass profile signature as a biomarker of early lung cancer
Widlak P, Pietrowska M, Polanska J, Marczyk M, Ros-Mazurczyk M, Dziadziuszko R, Jassem J, Rzyman W. Serum mass profile signature as a biomarker of early lung cancer. Lung Cancer 2016, 99: 46-52. PMID: 27565913, DOI: 10.1016/j.lungcan.2016.06.011.Peer-Reviewed Original ResearchConceptsEarly lung cancerLung cancerNegative predictive valuePredictive valueComputed tomographyEarly-stage lung cancerLow-dose computed tomographyIndeterminate pulmonary nodulesStage lung cancerPotential clinical usefulnessPositive predictive valueValidation cohortHealthy controlsClinical usefulnessDiscovery cohortBlood samplesIndependent cohortWeight serum fractionsPulmonary nodulesIndependent sample setCancerPatientsHealthy participantsMolecular biomarkersCohort
2014
Radiation-induced Changes in Levels of Selected Proteins in Peripheral Blood Serum of Breast Cancer Patients as a Potential Triage Biodosimeter for Large-scale Radiological Emergencies
Deperas-Kaminska M, Bajinskis A, Marczyk M, Polanska J, Wersäll P, Lidbrink E, Ainsbury EA, Guipaud O, Benderitter M, Haghdoost S, Wojcik A. Radiation-induced Changes in Levels of Selected Proteins in Peripheral Blood Serum of Breast Cancer Patients as a Potential Triage Biodosimeter for Large-scale Radiological Emergencies. Health Physics 2014, 107: 555-563. PMID: 25353241, DOI: 10.1097/hp.0000000000000158.Peer-Reviewed Original ResearchConceptsPeripheral blood serumBreast cancer patientsLarge-scale radiological emergencyCancer patientsApolipoprotein EConsistent dose-response relationshipBlood serumExternal beam radiotherapyIrradiation of skinKinase 4Dose-response relationshipLogistic regression modelsPartial-body exposuresPurpose of triageMultinomial logistic regression modelsBeam radiotherapyBlood samplesFetuin BMultivariate analysisBody exposureDifferent dosesRadiation-induced changesSerumProtein 7Factor XRadiation-Induced Changes in Serum Lipidome of Head and Neck Cancer Patients
Jelonek K, Pietrowska M, Ros M, Zagdanski A, Suchwalko A, Polanska J, Marczyk M, Rutkowski T, Skladowski K, Clench MR, Widlak P. Radiation-Induced Changes in Serum Lipidome of Head and Neck Cancer Patients. International Journal Of Molecular Sciences 2014, 15: 6609-6624. PMID: 24747595, PMCID: PMC4013650, DOI: 10.3390/ijms15046609.Peer-Reviewed Original ResearchConceptsSerum lipidomeConformal radiotherapyMedium dosesEnd of radiotherapyNeck cancer patientsRadiation-induced changesWhole patient bodyBody responsePost-treatment samplesDoses of radiationBlood levelsCancer patientsNeck cancerBlood samplesRadiotherapyNormal tissuesPatientsDosesCancer radiotherapyLipidomePatient's bodyTreatment samplesTissueLipid extractsCancer
2011
Comparison of peptide cancer signatures identified by mass spectrometry in serum of patients with head and neck, lung and colorectal cancers: association with tumor progression.
Pietrowska M, Polańska J, Suwiński R, Wideł M, Rutkowski T, Marczyk M, Domińczyk I, Ponge L, Marczak L, Polański A, Widłak P. Comparison of peptide cancer signatures identified by mass spectrometry in serum of patients with head and neck, lung and colorectal cancers: association with tumor progression. International Journal Of Oncology 2011, 40: 148-56. PMID: 21894432, DOI: 10.3892/ijo.2011.1186.Peer-Reviewed Original ResearchConceptsLung cancer samplesCancer samplesHealthy donorsSerum proteomeNon-small cell lung cancerNeck squamous cell cancerSquamous cell cancerCell lung cancerAdvanced cancer casesSera of patientsColorectal cancer samplesCancer signaturesInter-group analysisPeptide signaturesCell cancerClinical stageColorectal cancerCancer patientsLung cancerNeck cancerColorectal adenocarcinomaCancer casesSerum amyloidHealthy volunteersBlood samplesRadiation-related Changes in Serum Proteome Profiles Detected by Mass Spectrometry in Blood of Patients Treated with Radiotherapy Due to Larynx Cancer
WIDŁAK P, PIETROWSKA M, WOJTKIEWICZ K, RUTKOWSKI T, WYGODA A, MARCZAK Ł, MARCZYK M, POLAŃSKA J, WALASZCZYK A, DOMIŃCZYK I, SKŁADOWSKI K, STOBIECKI M, POLAŃSKI A. Radiation-related Changes in Serum Proteome Profiles Detected by Mass Spectrometry in Blood of Patients Treated with Radiotherapy Due to Larynx Cancer. Journal Of Radiation Research 2011, 52: 575-581. PMID: 21768750, DOI: 10.1269/jrr.11019.Peer-Reviewed Original ResearchConceptsMass spectrometrySerum samplesLarynx cancerTotal dosesSerum proteomeEnd of radiotherapyStart of radiotherapyRadiation-related changesBlood of patientsConsecutive blood samplesSerum proteome profilesMALDI-TOF mass spectrometryEarly time pointsHuman serum proteomeRadical radiotherapyPeptide ionsBlood samplesPatientsProteome profilesFinal irradiationRetrospective markerPilot studyRadiotherapyTime pointsAnalysed groupAssociation between plasma proteome profiles analysed by mass spectrometry, a lymphocyte-based DNA-break repair assay and radiotherapy-induced acute mucosal reaction in head and neck cancer patients
Pietrowska M, Polańska J, Walaszczyk A, Wygoda A, Rutkowski T, Składowski K, Marczak Ł, Stobiecki M, Marczyk M, Polański A, Widłak P. Association between plasma proteome profiles analysed by mass spectrometry, a lymphocyte-based DNA-break repair assay and radiotherapy-induced acute mucosal reaction in head and neck cancer patients. International Journal Of Radiation Biology 2011, 87: 711-719. PMID: 21351848, DOI: 10.3109/09553002.2011.556174.Peer-Reviewed Original ResearchConceptsAcute mucosal reactionsAcute reactionsMucosal reactionsNeck cancerPlasma proteomeNeck cancer patientsPlasma proteome profilesDefinitive radiotherapyCancer patientsPredictive markerHealthy donorsBlood samplesHealthy individualsPatientsRadiotherapyPlasma samplesComet assayLymphocytesCancerMaximal intensityMarkersProteome profiles