2020
Twist2 is NFkB-responsive when p120-catenin is inactivated and EGFR is overexpressed in esophageal keratinocytes
Lehman H, Kidacki M, Stairs D. Twist2 is NFkB-responsive when p120-catenin is inactivated and EGFR is overexpressed in esophageal keratinocytes. Scientific Reports 2020, 10: 18829. PMID: 33139779, PMCID: PMC7608670, DOI: 10.1038/s41598-020-75866-0.Peer-Reviewed Original ResearchConceptsEsophageal squamous cell carcinomaCancer typesYear of diagnosisSquamous cell carcinomaEsophageal keratinocytesOverexpression of EGFRHuman esophageal keratinocytesAggressive cell typesFatal cancer typePoor prognosisCell carcinomaTwist2 expressionEGFR overexpressionEGFREMT-inducing geneNFkBResponsive targetsTwist2Paucity of researchCell typesPresent studyKeratinocytesP120-cateninOverexpressionComplete loss
2017
p120-Catenin Downregulation and PIK3CA Mutations Cooperate to Induce Invasion through MMP1 in HNSCC
Kidacki M, Lehman HL, Green MV, Warrick JI, Stairs DB. p120-Catenin Downregulation and PIK3CA Mutations Cooperate to Induce Invasion through MMP1 in HNSCC. Molecular Cancer Research 2017, 15: 1398-1409. PMID: 28637905, DOI: 10.1158/1541-7786.mcr-17-0108.Peer-Reviewed Original ResearchMeSH KeywordsCarcinoma, Squamous CellCateninsCell Line, TumorCell MovementClass I Phosphatidylinositol 3-KinasesDelta CateninDown-RegulationGene Expression Regulation, NeoplasticHead and Neck NeoplasmsHumansMatrix Metalloproteinase 1MutationNeoplasm InvasivenessSquamous Cell Carcinoma of Head and NeckConceptsPI3K pathway mutationsNeck squamous cell carcinomaPathway mutationsInhibition of MMP1Squamous cell carcinomaSubset of HNSCCsPotential novel targetAdvanced diseaseCancer Genome AtlasCell carcinomaPIK3CA mutationsHNSCC invasionOral keratinocytesPatient specimensCancer ResHNSCCNovel targetMetastasisMMP1Genome AtlasPotential targetDownregulationIdentification of mechanismsAggressive behaviorInvasion
2016
The Role of p120‐catenin and PIK3CA in Migration in Head and Neck Squamous Cell Carcinoma
Kidacki M, Lehman H, Welsh P, Warrick J, Stairs D. The Role of p120‐catenin and PIK3CA in Migration in Head and Neck Squamous Cell Carcinoma. The FASEB Journal 2016, 30 DOI: 10.1096/fasebj.30.1_supplement.439.8.Peer-Reviewed Original ResearchNormal oral keratinocytesNeck squamous cell carcinomaSquamous cell carcinomaPIK3CA mutationsCell carcinomaInvasive capabilityCell linesBoyden chamber migration assaysPhospho-STAT3Time of diagnosisCell migrationE545KEpithelial cancer modelsMalignant cell populationMigration/invasionDistant metastasisSame patientCancer aggressivenessOral keratinocytesCancer modelPIK3CA mutantsTumorigenic effectsHNSCCPatientsMetastasis