2015
A Preliminary Prospective Study of an Escalation in ‘Maximum Daily Drinks’, Fronto-Parietal Circuitry and Impulsivity-Related Domains in Young Adult Drinkers
Worhunsky PD, Dager AD, Meda SA, Khadka S, Stevens MC, Austad CS, Raskin SA, Tennen H, Wood RM, Fallahi CR, Potenza MN, Pearlson GD. A Preliminary Prospective Study of an Escalation in ‘Maximum Daily Drinks’, Fronto-Parietal Circuitry and Impulsivity-Related Domains in Young Adult Drinkers. Neuropsychopharmacology 2015, 41: 1637-1647. PMID: 26514582, PMCID: PMC4832027, DOI: 10.1038/npp.2015.332.Peer-Reviewed Original ResearchConceptsAlcohol useYoung adult drinkersYoung adultsPreliminary prospective studyAdult drinkersExcessive alcohol useAlcohol use disorderFunctional network activityProspective studyUse disordersFunctional brain networksGo/No-Go taskNeurobiological alterationsDomain scoresGreater riskDaily drinksAddictive disordersDrinkersDrinking occasionsLongitudinal studyFronto-parietal circuitryBrain networksA preliminary study of the effects of working memory training on brain function
Stevens MC, Gaynor A, Bessette KL, Pearlson GD. A preliminary study of the effects of working memory training on brain function. Brain Imaging And Behavior 2015, 10: 387-407. PMID: 26138580, PMCID: PMC4698365, DOI: 10.1007/s11682-015-9416-2.Peer-Reviewed Original ResearchConceptsAttention-deficit/hyperactivity disorderWM trainingMemory trainingBrain regionsDifferent neural correlatesBrain functionADHD symptom severityTraining-related changesTemporal lobe regionsDifferent symptom typesWM abilityExecutive processingWM performanceFMRI taskFrontoparietal circuitsNeural correlatesBrain activationHyperactivity disorderNeuropsychological testsNeural changesBrain activityTask phasesLobe regionsActivation gainControl participantsNeuroimaging data sharing on the neuroinformatics database platform
Book GA, Stevens MC, Assaf M, Glahn DC, Pearlson GD. Neuroimaging data sharing on the neuroinformatics database platform. NeuroImage 2015, 124: 1089-1092. PMID: 25888923, PMCID: PMC4608854, DOI: 10.1016/j.neuroimage.2015.04.022.Peer-Reviewed Original ResearchSocial Function and Communication in Optimal Outcome Children and Adolescents with an Autism History on Structured Test Measures
Orinstein AJ, Suh J, Porter K, De Yoe KA, Tyson KE, Troyb E, Barton ML, Eigsti IM, Stevens MC, Fein DA. Social Function and Communication in Optimal Outcome Children and Adolescents with an Autism History on Structured Test Measures. Journal Of Autism And Developmental Disorders 2015, 45: 2443-2463. PMID: 25758821, PMCID: PMC4515156, DOI: 10.1007/s10803-015-2409-6.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAttentionAutistic DisorderChildCommunicationEmotionsFemaleHumansLanguageMaleNeuropsychological TestsSocial AdjustmentSocial PerceptionSocial SkillsYoung AdultConceptsHigh functioning autismOO participantsOptimal Outcome ChildrenPragmatic language deficitsAttentional problemsCommunication symptomsTD youthTD peersSocial abilitiesSocial difficultiesCommunicative impairmentsASD diagnosisLanguage deficitsOutcomes childrenTest measuresCommunication difficultiesGroup differencesSocial relationshipsYouthSocial functionParticipantsLess insightDifficultiesOptimal outcomesAutism
2013
Hoarding disorder and obsessive–compulsive disorder show different patterns of neural activity during response inhibition
Tolin DF, Witt ST, Stevens MC. Hoarding disorder and obsessive–compulsive disorder show different patterns of neural activity during response inhibition. Psychiatry Research 2013, 221: 142-148. PMID: 24389161, PMCID: PMC3946244, DOI: 10.1016/j.pscychresns.2013.11.009.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderGo/NoGo taskFunctional magnetic resonance imagingOCD patientsHD patientsResponse inhibitionNoGo taskHealthy controlsGo/NoGo task performanceDistinct neural underpinningsRight orbitofrontal gyrusErrors of commissionNeural underpinningsOrbitofrontal activationTask performanceCorrect rejectsMagnetic resonance imagingHemodynamic activityFrontal hypoactivityNeural activityOrbitofrontal gyrusBehavioral dataHemodynamic responsePatientsPreliminary evidenceAcademic abilities in children and adolescents with a history of autism spectrum disorders who have achieved optimal outcomes
Troyb E, Orinstein A, Tyson K, Helt M, Eigsti IM, Stevens M, Fein D. Academic abilities in children and adolescents with a history of autism spectrum disorders who have achieved optimal outcomes. Autism 2013, 18: 233-243. PMID: 24096312, PMCID: PMC4481875, DOI: 10.1177/1362361312473519.Peer-Reviewed Original ResearchMeSH KeywordsAchievementAdolescentCase-Control StudiesChildChild Development Disorders, PervasiveFemaleHumansMaleNeuropsychological TestsProblem SolvingReadingWritingYoung AdultConceptsAutism spectrum disorder diagnosisAutism spectrum disorderAcademic abilityAutism groupSpectrum disorderHigh-functioning individualsAverage rangeDisorder diagnosisNonverbal IQVerbal IQLanguage skillsSchool supportSubtestsIQComprehensionAdolescentsOngoing difficultiesOptimal outcomesPeersIndividualsMathematical problemDisordersChildrenAbilitySkillsDTI-measured white matter abnormalities in adolescents with Conduct Disorder
Haney-Caron E, Caprihan A, Stevens MC. DTI-measured white matter abnormalities in adolescents with Conduct Disorder. Journal Of Psychiatric Research 2013, 48: 111-120. PMID: 24139595, PMCID: PMC3863548, DOI: 10.1016/j.jpsychires.2013.09.015.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAnisotropyBrainBrain MappingConduct DisorderDiffusion Tensor ImagingFemaleHumansLeukoencephalopathiesMaleNerve Fibers, MyelinatedNeuropsychological TestsConceptsFractional anisotropyAxial diffusivityWhite matter microstructureMicrostructural abnormalitiesLong-range white matter connectionsWhite matter microstructural abnormalitiesWhite matter abnormalitiesDiffusion tensor imaging (DTI) findingsAnatomical connectivity abnormalitiesLower fractional anisotropySuperior corona radiataAbnormal white matter microstructureBrain white matter microstructureDifferent brain regionsWhite matter connectionsTemporal lobe regionsFronto-occipital fasciculusTwo-sample t-testFunctional neuroimaging studiesCD ageCD adolescentsMajor white matterImaging findingsRadial diffusivity measurementsStudy groupProlonged hemodynamic response during incidental facial emotion processing in inter-episode bipolar I disorder
Rosenfeld ES, Pearlson GD, Sweeney JA, Tamminga CA, Keshavan MS, Nonterah C, Stevens MC. Prolonged hemodynamic response during incidental facial emotion processing in inter-episode bipolar I disorder. Brain Imaging And Behavior 2013, 8: 73-86. PMID: 23975275, PMCID: PMC3944373, DOI: 10.1007/s11682-013-9246-z.Peer-Reviewed Original ResearchConceptsFMRI studyDorsolateral prefrontal cortex responsesAutomatic emotion regulationAffectively salient stimuliFacial emotion processingGender discrimination taskBrain regionsRemitted bipolar disorderPrefrontal cortex responsesResidual mood symptomsPrefrontal cortex regionsDiagnostic group differencesVentromedial prefrontal cortex regionsCortex brain regionsAngry expressionsEmotion regulationEmotion processingEmotional processingBrain activationTask performanceHemodynamic responseEmotional reactionsBipolar disorderBipolar IPrefrontal cortexError processing in current and former cocaine users
Castelluccio BC, Meda SA, Muska CE, Stevens MC, Pearlson GD. Error processing in current and former cocaine users. Brain Imaging And Behavior 2013, 8: 87-96. PMID: 23949893, PMCID: PMC3925762, DOI: 10.1007/s11682-013-9247-y.Peer-Reviewed Original ResearchConceptsFormer cocaine usersError processingSupramarginal gyrusCocaine usersBOLD responseRight inferior parietal lobuleAspects of impulsivityAbstinent cocaine usersCocaine abuse/dependenceInferior parietal lobuleCocaine-dependent individualsCurrent cocaine usersCognitive compensationNeural differencesPrepotent responsesResponse inhibitionAbuse/dependenceCorrect rejectionsSpecific deficitsBOLD activityTrait measuresMaladaptive behaviorsParietal lobuleAddictive behaviorsNeural activityA large scale (N=102) functional neuroimaging study of response inhibition in a Go/NoGo task
Steele VR, Aharoni E, Munro GE, Calhoun VD, Nyalakanti P, Stevens MC, Pearlson G, Kiehl KA. A large scale (N=102) functional neuroimaging study of response inhibition in a Go/NoGo task. Behavioural Brain Research 2013, 256: 529-536. PMID: 23756137, PMCID: PMC4437665, DOI: 10.1016/j.bbr.2013.06.001.Peer-Reviewed Original ResearchConceptsSuccessful response inhibitionGo/NoGo taskResponse inhibitionUnsuccessful response inhibitionMagnetic resonance imaging studySupplementary motor areaResonance imaging studyFunctional magnetic resonance imaging studyInferior parietal lobuleNoGo taskInferior prefrontal regionsHealthy adult participantsBasal gangliaInferior frontal gyrusHemodynamic responseMotor areaAnterior cingulateImaging studiesParietal lobuleFronto-parietal networkHemodynamic activityFrontal gyrusFrontostriatal regionsSmall sample studiesPrefrontal regions
2012
Examining the effect of psychopathic traits on gray matter volume in a community substance abuse sample
Cope LM, Shane MS, Segall JM, Nyalakanti PK, Stevens MC, Pearlson GD, Calhoun VD, Kiehl KA. Examining the effect of psychopathic traits on gray matter volume in a community substance abuse sample. Psychiatry Research 2012, 204: 91-100. PMID: 23217577, PMCID: PMC3536442, DOI: 10.1016/j.pscychresns.2012.10.004.Peer-Reviewed Original ResearchMeSH KeywordsAdultAntisocial Personality DisorderBrainCognition DisordersFemaleHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingMaleMiddle AgedNerve Fibers, MyelinatedNeuropsychological TestsPersonality InventoryPsychiatric Status Rating ScalesRegression AnalysisResidence CharacteristicsSubstance-Related DisordersConceptsGray matter volumeMatter volumeOrbital frontal cortexMagnetic resonance imagingRight hippocampusFrontal cortexBilateral orbital frontal cortexRight anterior cingulateGray matter reductionsGray matter increasesStructural imaging studiesLimbic regionsBrain abnormalitiesRight insulaParalimbic regionsAnterior cingulateLifetime drugSubstance abuse sampleResonance imagingImaging studiesAlcohol useExploratory regression analysisRegression analysisLimbicMatter reductionDefault mode network activity and white matter integrity in healthy middle-aged ApoE4 carriers
Patel KT, Stevens MC, Pearlson GD, Winkler AM, Hawkins KA, Skudlarski P, Bauer LO. Default mode network activity and white matter integrity in healthy middle-aged ApoE4 carriers. Brain Imaging And Behavior 2012, 7: 60-67. PMID: 23011382, DOI: 10.1007/s11682-012-9187-y.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnxietyApolipoprotein E4BrainData Interpretation, StatisticalDepressionDiffusion Tensor ImagingDNAFemaleGenotypeHeterozygoteHumansImage Processing, Computer-AssistedIntelligence TestsMagnetic Resonance ImagingMaleMiddle AgedNerve NetNeuropsychological TestsPrincipal Component AnalysisSmokingWechsler ScalesConceptsAPOE4 carriersMagnetic resonance imagingAlzheimer's diseaseFractional anisotropyFunctional MRI abnormalitiesUnderlying neuropathologic changesWhite matter fractional anisotropyWhite matter changesDefault mode network connectivityDefault mode network activityGenetic risk factorsMode network connectivityMiddle-aged adultsWhite matter integrityMRI abnormalitiesNeuropathologic changesRisk factorsApolipoprotein EMatter changesCognitive declineResonance imagingOlder ageFunctional connectivityGenetic riskDMN regionsNeuropsychological Assessment and The Paradox of ADHD
Koziol L, Stevens M. Neuropsychological Assessment and The Paradox of ADHD. Applied Neuropsychology Child 2012, 1: 79-89. PMID: 23428294, DOI: 10.1080/21622965.2012.694764.Peer-Reviewed Original ResearchMeSH KeywordsAttention Deficit Disorder with HyperactivityDiagnostic and Statistical Manual of Mental DisordersHumansNerve NetNeuropsychological TestsConceptsAttention deficit hyperactivity disorderCauses of ADHDBrain network studiesHyperactivity disorderNeuropsychological testsFunctional neuroanatomyNeuropsychological assessmentNeuropsychological evaluationMental disorder diagnosesDimensional approachDisorder diagnosisResearch paradigmStatistical ManualDiagnostic assessmentDisordersNeuropsychologistsNeuroanatomyParadigmNetwork studiesTopical reviewClinical settingClinical diagnosisDiagnosis
2011
Cortical Thickness and Folding Deficits in Conduct-Disordered Adolescents
Hyatt CJ, Haney-Caron E, Stevens MC. Cortical Thickness and Folding Deficits in Conduct-Disordered Adolescents. Biological Psychiatry 2011, 72: 207-214. PMID: 22209639, PMCID: PMC3367056, DOI: 10.1016/j.biopsych.2011.11.017.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAge of OnsetAttention Deficit Disorder with HyperactivityCerebral CortexChildConduct DisorderFemaleFunctional LateralityHumansImage Processing, Computer-AssistedLinear ModelsMagnetic Resonance ImagingMaleNeuropsychological TestsPrefrontal CortexPsychiatric Status Rating ScalesPsychomotor PerformanceSoftwareConceptsCortical thicknessParietal lobeBrain regionsControl subjectsParacentral lobuleConduct disorderThinner cortexCD participantsTemporal lobe structural abnormalitiesPure conduct disorderLocal gyrification indexBrain structure imagesAnterior brain regionsDifferent brain regionsSurface-based morphometryPosterior brain regionsTemporoparietal junctionBrain abnormalitiesGyrification indexTemporal lobeAnterior cingulateFrontal lobeDorsomedial prefrontalStructural abnormalitiesOrbitofrontal cortex
2010
Functional Imaging of Cognitive Control During Acute Alcohol Intoxication
Anderson BM, Stevens MC, Meda SA, Jordan K, Calhoun VD, Pearlson GD. Functional Imaging of Cognitive Control During Acute Alcohol Intoxication. Alcohol Clinical And Experimental Research 2010, 35: 156-165. PMID: 20958334, PMCID: PMC3005103, DOI: 10.1111/j.1530-0277.2010.01332.x.Peer-Reviewed Original ResearchConceptsCognitive controlError processingBrain regionsAnterior cingulateFunctional magnetic resonance imaging (fMRI) taskFunctional MRILateral prefrontal cortexParietal brain regionsFalse alarm responsesBrain hemodynamic activityFalse alarm errorsParietal lobe regionsNeural basisBehavioral performancePrefrontal cortexFMRI analysisHemodynamic activityLobe regionsAcute alcohol intoxicationAlarm errorsAlcohol effectsReaction timeAlcohol intoxicationCingulateAlarm responseDecreased prefrontal cortex activity in mild traumatic brain injury during performance of an auditory oddball task
Witt ST, Lovejoy DW, Pearlson GD, Stevens MC. Decreased prefrontal cortex activity in mild traumatic brain injury during performance of an auditory oddball task. Brain Imaging And Behavior 2010, 4: 232-247. PMID: 20703959, DOI: 10.1007/s11682-010-9102-3.Peer-Reviewed Original ResearchConceptsMild TBI patientsMild traumatic brain injuryTraumatic brain injuryBrain activityRight dorsolateral prefrontal cortexActive information maintenanceCompensatory brain activityDefault mode network dysfunctionPrefrontal cortex activityAuditory oddball taskDorsolateral prefrontal cortexTBI patientsPersistent cognitive deficitsBrain injurySimilar topographical patternEffortful formsExecutive tasksExecutive abilitiesOddball taskTask performanceMental effortNovel stimuliStimulus detectionCortex activityPrefrontal cortex
2009
Evidence for Anomalous Network Connectivity during Working Memory Encoding in Schizophrenia: An ICA Based Analysis
Meda SA, Stevens MC, Folley BS, Calhoun VD, Pearlson GD. Evidence for Anomalous Network Connectivity during Working Memory Encoding in Schizophrenia: An ICA Based Analysis. PLOS ONE 2009, 4: e7911. PMID: 19936244, PMCID: PMC2775682, DOI: 10.1371/journal.pone.0007911.Peer-Reviewed Original ResearchConceptsTask accuracyFunctional connectivityPrefrontal cortexNetwork engagementLeft fronto-parietal networkRight dorsolateral prefrontal cortexMemory fMRI paradigmWorking Memory EncodingFronto-parietal networkVentrolateral prefrontal cortexNumerous neuroimaging studiesDorsolateral prefrontal cortexIndependent component analysisAbnormal regional brain activityDefault mode networkBrain network integrationDysfunctional brain regionsPrevious schizophrenia studiesRegional brain activityHippocampus/parahippocampusMemory encodingFMRI taskMemory cognitionMemory performanceFMRI paradigmAge-related cognitive gains are mediated by the effects of white matter development on brain network integration
Stevens MC, Skudlarski P, Pearlson GD, Calhoun VD. Age-related cognitive gains are mediated by the effects of white matter development on brain network integration. NeuroImage 2009, 48: 738-746. PMID: 19577651, PMCID: PMC2753497, DOI: 10.1016/j.neuroimage.2009.06.065.Peer-Reviewed Original ResearchConceptsCognitive controlBrain activityWhite matter developmentDevelopmental cognitive neuroscienceExecutive cognitive abilityBrain network integrationWhite matter coherenceCognitive neuroscienceCognitive abilitiesResponse inhibitionAdolescent developmentCognitive gainsBehavioral performanceSpecific white matter regionsFunctional integrationAge-related changesFirst multimodalBehavioral controlFunctional connectivityMaturational factorsBrain regionsLocal processingNetwork integrationFunctional circuitsNeuroscienceDouble dissociation between perspective-taking and empathic-concern as predictors of hemodynamic response to another's mistakes
Shane MS, Stevens MC, Harenski CL, Kiehl KA. Double dissociation between perspective-taking and empathic-concern as predictors of hemodynamic response to another's mistakes. Social Cognitive And Affective Neuroscience 2009, 4: 111-118. PMID: 19244454, PMCID: PMC2686223, DOI: 10.1093/scan/nsn043.Peer-Reviewed Original ResearchConceptsSelf-reported empathic concernParticipants' levelInferior parietal cortexSense of agencyEmpathic concernDouble dissociationFunctional dissociationHemodynamic responseParietal cortexAction patternsBasic representationVACCObserved errorsMistakesSelfCortexStrong evidenceProcessingSeparate rolesDissociationRecognitionPredictorsUnderstanding
2007
Brain network dynamics during error commission
Stevens MC, Kiehl KA, Pearlson GD, Calhoun VD. Brain network dynamics during error commission. Human Brain Mapping 2007, 30: 24-37. PMID: 17979124, PMCID: PMC2669663, DOI: 10.1002/hbm.20478.Peer-Reviewed Original ResearchConceptsError commissionGo/No-Go taskVisual Go/No-Go taskHigher-order cognitive controlFunctional magnetic resonance imaging (fMRI) dataLateral prefrontal cortexPrefrontal brain regionsWhole-brain functional connectivityPregenual cingulate cortexAnterior temporal lobeBrain network dynamicsInferior parietal lobuleAdult healthy participantsBrain functional connectivityCognitive controlIndependent component analysisButton pressHemodynamic activationAffective responsesDevelopmental differencesNeurobiological differencesParietal lobulePrefrontal cortexAnterior cingulateError detection network