2015
Relationship between white matter microstructure abnormalities and ADHD symptomatology in adolescents
Witt ST, Stevens MC. Relationship between white matter microstructure abnormalities and ADHD symptomatology in adolescents. Psychiatry Research 2015, 232: 168-174. PMID: 25795595, PMCID: PMC4417010, DOI: 10.1016/j.pscychresns.2015.02.009.Peer-Reviewed Original Research
2013
Diffusion Tensor Imaging White Matter Endophenotypes in Patients With Schizophrenia or Psychotic Bipolar Disorder and Their Relatives
Skudlarski P, Schretlen DJ, Thaker GK, Stevens MC, Keshavan MS, Sweeney JA, Tamminga CA, Clementz BA, O’Neil K, Pearlson GD. Diffusion Tensor Imaging White Matter Endophenotypes in Patients With Schizophrenia or Psychotic Bipolar Disorder and Their Relatives. American Journal Of Psychiatry 2013, 170: 886-898. PMID: 23771210, DOI: 10.1176/appi.ajp.2013.12111448.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAnisotropyBipolar DisorderBrainDiffusion Tensor ImagingDominance, CerebralEndophenotypesGenetic Predisposition to DiseaseHumansImage Interpretation, Computer-AssistedLeukoencephalopathiesNerve NetPhenotypePsychiatric Status Rating ScalesReference ValuesSchizophreniaSchizophrenic PsychologyStatistics as TopicConceptsPsychotic bipolar disorderBipolar disorderWhite matter integrityFractional anisotropyComparison subjectsFractional anisotropy decreasesFirst-degree relativesHealthy comparison subjectsLower white matter integrityDiffusion tensorMultiple white matter regionsLower fractional anisotropyWhite matter regionsBipolar-Schizophrenia NetworkHealthy subjectsBipolar relativesProband groupsYoung subjectsBrain regionsDisease specificityFractional anisotropy measuresUnaffected relativesMatter regionsBrain connectivitySchizophreniaIs Aberrant Functional Connectivity A Psychosis Endophenotype? A Resting State Functional Magnetic Resonance Imaging Study
Khadka S, Meda SA, Stevens MC, Glahn DC, Calhoun VD, Sweeney JA, Tamminga CA, Keshavan MS, O’Neil K, Schretlen D, Pearlson GD. Is Aberrant Functional Connectivity A Psychosis Endophenotype? A Resting State Functional Magnetic Resonance Imaging Study. Biological Psychiatry 2013, 74: 458-466. PMID: 23746539, PMCID: PMC3752322, DOI: 10.1016/j.biopsych.2013.04.024.Peer-Reviewed Original ResearchConceptsPsychotic bipolar probandsNegative Syndrome Scale (PANSS) negative scoresState functional magnetic resonance imaging studyFunctional connectivityState functional magnetic resonanceBipolar disorder shareBrain connectivity abnormalitiesPosterior default mode networkSchizophrenia probandsMagnetic resonance imaging studyRespective first-degree relativesAberrant functional connectivityBipolar probandsFirst-degree relativesGroup differencesPsychosis endophenotypesNegative Syndrome ScaleResonance imaging studyFunctional magnetic resonance imaging studyDefault mode networkFunctional magnetic resonanceFunctional connectivity measuresFunctional Brain Networks Associated With Cognitive Control, Cocaine Dependence, and Treatment Outcome
Worhunsky PD, Stevens MC, Carroll KM, Rounsaville BJ, Calhoun VD, Pearlson GD, Potenza MN. Functional Brain Networks Associated With Cognitive Control, Cocaine Dependence, and Treatment Outcome. Psychology Of Addictive Behaviors 2013, 27: 477-488. PMID: 22775772, PMCID: PMC3743442, DOI: 10.1037/a0029092.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnalysis of VarianceBehavior, AddictiveCase-Control StudiesCerebral CortexCocaine-Related DisordersCognitive Behavioral TherapyData Interpretation, StatisticalExecutive FunctionFemaleFunctional NeuroimagingHumansLimbic SystemLinear ModelsMagnetic Resonance ImagingMaleMotivationNerve NetOxygenPrincipal Component AnalysisPsychomotor PerformanceStroop TestTreatment OutcomeConceptsCognitive controlCocaine dependencePoor cognitive controlCognitive control processesFunctional networksTreatment retentionDistinct functional networksIndependent component analysisFunctional brain networksConflict monitoringStroop taskTreatment outcome measuresMotivational processingCocaine-dependent patientsPrefrontal networkBrain networksSubcortical networksFunctional connectivityControl participantsFMRI dataRegional activationReduced involvementCortical networksTreatment developmentControl processTask-related concurrent but opposite modulations of overlapping functional networks as revealed by spatial ICA
Xu J, Zhang S, Calhoun VD, Monterosso J, Li CS, Worhunsky PD, Stevens M, Pearlson GD, Potenza MN. Task-related concurrent but opposite modulations of overlapping functional networks as revealed by spatial ICA. NeuroImage 2013, 79: 62-71. PMID: 23611864, PMCID: PMC3677796, DOI: 10.1016/j.neuroimage.2013.04.038.Peer-Reviewed Original ResearchConceptsCommon brain regionsSpatial independent component analysisDifferent functional networksMedial frontoparietal corticesFunctional networksCognitive tasksBrain regionsFrontoparietal cortexMultiple cognitive processesFunctional magnetic resonance imaging (fMRI) dataHigher-order association corticesTask-related modulationSame brain regionsCognitive processesVisual tasksMagnetic resonance imaging dataVentral tegmental areaPosterior cingulateAssociation cortexHealthy participantsHuman brainTimecoursesSubcortical structuresSpatial ICATaskThe role of top-down control in different phases of a sensorimotor timing task: a DCM study of adults and adolescents
Witt ST, Stevens MC. The role of top-down control in different phases of a sensorimotor timing task: a DCM study of adults and adolescents. Brain Imaging And Behavior 2013, 7: 260-273. PMID: 23475755, PMCID: PMC3743949, DOI: 10.1007/s11682-013-9224-5.Peer-Reviewed Original ResearchConceptsPrefrontal cortexLow-level sensorySignificant maturational effectsVentrolateral prefrontal cortexDynamic causal modelingInternal clock mechanismFinger-tapping taskCognitive controlSensorimotor timingBehavioral accuracyAuditory cuesTiming taskFMRI studyBaseline connectivitySensory regionsCognitive functionDCM studySensory stimuliCausal modelingAuditory cortexMotor regionsCuesBrain regionsAccurate performanceMotor controlMonetary Reward Processing in Obese Individuals With and Without Binge Eating Disorder
Balodis IM, Kober H, Worhunsky PD, White MA, Stevens MC, Pearlson GD, Sinha R, Grilo CM, Potenza MN. Monetary Reward Processing in Obese Individuals With and Without Binge Eating Disorder. Biological Psychiatry 2013, 73: 877-886. PMID: 23462319, PMCID: PMC3686098, DOI: 10.1016/j.biopsych.2013.01.014.Peer-Reviewed Original ResearchConceptsReward/loss processingReward processingLoss processingVentromedial prefrontal cortex activityFunctional magnetic resonance imagingMonetary reward processingPrefrontal cortex activityBinge Eating DisorderVentral striatal activityNeural differencesNeural correlatesLoss taskLoss prospectsNeurobiological underpinningsCortex activityEating DisordersRegional activationVentral striatumBED groupAnticipatory phaseStriatal activityProcessingIndividualsOB groupObese individuals
2012
Reduced Functional Connectivity of Prefrontal Regions and Amygdala Within Affect and Working Memory Networks in Pediatric Bipolar Disorder
Passarotti AM, Ellis J, Wegbreit E, Stevens MC, Pavuluri MN. Reduced Functional Connectivity of Prefrontal Regions and Amygdala Within Affect and Working Memory Networks in Pediatric Bipolar Disorder. Brain Connectivity 2012, 2: 320-334. PMID: 23035965, PMCID: PMC3621331, DOI: 10.1089/brain.2012.0089.Peer-Reviewed Original ResearchConceptsVentrolateral prefrontal cortexPediatric bipolar disorderRight ventrolateral prefrontal cortexWorking Memory NetworkFunctional connectivityMemory taskDorsolateral PFCBrain networksRight amygdalaMemory networkEmotion processing regionsEmotion regulation regionsDifferential functional connectivityFunctional magnetic resonanceBilateral temporal regionsConnected brain networksRegulation regionRegional functional connectivityNeutral facesEmotion processingCognitive processesEmotion evaluationPrefrontal regionsProcessing regionsBipolar disorderInfluence of Alcohol Use and Family History of Alcoholism on Neural Response to Alcohol Cues in College Drinkers
Dager AD, Anderson BM, Stevens MC, Pulido C, Rosen R, Jiantonio‐Kelly R, Sisante J, Raskin SA, Tennen H, Austad CS, Wood RM, Fallahi CR, Pearlson GD. Influence of Alcohol Use and Family History of Alcoholism on Neural Response to Alcohol Cues in College Drinkers. Alcohol Clinical And Experimental Research 2012, 37: e161-e171. PMID: 23078363, PMCID: PMC3548054, DOI: 10.1111/j.1530-0277.2012.01879.x.Peer-Reviewed Original ResearchConceptsAlcohol cue reactivityFamily historyHeavy drinkersCue reactivityLight drinkersHeavy drinkingMagnetic resonance imaging responseBOLD responseBlood oxygen level-dependent (BOLD) contrastAlcohol cuesVisual association regionsAlcohol use disorderAlcohol imagesFunctional magnetic resonance imaging (fMRI) responsesMedial frontal cortexGreater BOLD responseLevel-dependent contrastTemporo-parietal regionsRisk factorsFrontal cortexDorsal striatumUse disordersAnterior cingulateBeverage imagesImaging responseDefault mode network activity and white matter integrity in healthy middle-aged ApoE4 carriers
Patel KT, Stevens MC, Pearlson GD, Winkler AM, Hawkins KA, Skudlarski P, Bauer LO. Default mode network activity and white matter integrity in healthy middle-aged ApoE4 carriers. Brain Imaging And Behavior 2012, 7: 60-67. PMID: 23011382, DOI: 10.1007/s11682-012-9187-y.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnxietyApolipoprotein E4BrainData Interpretation, StatisticalDepressionDiffusion Tensor ImagingDNAFemaleGenotypeHeterozygoteHumansImage Processing, Computer-AssistedIntelligence TestsMagnetic Resonance ImagingMaleMiddle AgedNerve NetNeuropsychological TestsPrincipal Component AnalysisSmokingWechsler ScalesConceptsAPOE4 carriersMagnetic resonance imagingAlzheimer's diseaseFractional anisotropyFunctional MRI abnormalitiesUnderlying neuropathologic changesWhite matter fractional anisotropyWhite matter changesDefault mode network connectivityDefault mode network activityGenetic risk factorsMode network connectivityMiddle-aged adultsWhite matter integrityMRI abnormalitiesNeuropathologic changesRisk factorsApolipoprotein EMatter changesCognitive declineResonance imagingOlder ageFunctional connectivityGenetic riskDMN regionsNeuropsychological Assessment and The Paradox of ADHD
Koziol L, Stevens M. Neuropsychological Assessment and The Paradox of ADHD. Applied Neuropsychology Child 2012, 1: 79-89. PMID: 23428294, DOI: 10.1080/21622965.2012.694764.Peer-Reviewed Original ResearchConceptsAttention deficit hyperactivity disorderCauses of ADHDBrain network studiesHyperactivity disorderNeuropsychological testsFunctional neuroanatomyNeuropsychological assessmentNeuropsychological evaluationMental disorder diagnosesDimensional approachDisorder diagnosisResearch paradigmStatistical ManualDiagnostic assessmentDisordersNeuropsychologistsNeuroanatomyParadigmNetwork studiesTopical reviewClinical settingClinical diagnosisDiagnosisMultiple resting state network functional connectivity abnormalities in mild traumatic brain injury
Stevens MC, Lovejoy D, Kim J, Oakes H, Kureshi I, Witt ST. Multiple resting state network functional connectivity abnormalities in mild traumatic brain injury. Brain Imaging And Behavior 2012, 6: 293-318. PMID: 22555821, DOI: 10.1007/s11682-012-9157-4.Peer-Reviewed Original ResearchConceptsTraumatic brain injuryMild traumatic brain injuryMild TBI patientsFunctional connectivity abnormalitiesTBI patientsBrain injuryConnectivity abnormalitiesFunctional connectivitySevere traumatic brain injuryWhite matter microstructural damagePostconcussive symptom severityWhole-brain functional connectivityFunctional connectivity deficitsCompensatory neural processesBrain networksBrain functional connectivityHealthy control participantsVoxelwise group comparisonsIntracerebral injuryNeurobiological sequelaeConnectivity deficitsAnterior cingulateBrain regionsSymptom severityAnatomical connectivity
2011
Amygdala Functional Connectivity Predicts Pharmacotherapy Outcome in Pediatric Bipolar Disorder
Wegbreit E, Ellis JA, Nandam A, Fitzgerald JM, Passarotti AM, Pavuluri MN, Stevens MC. Amygdala Functional Connectivity Predicts Pharmacotherapy Outcome in Pediatric Bipolar Disorder. Brain Connectivity 2011, 1: 411-422. PMID: 22432455, PMCID: PMC3604767, DOI: 10.1089/brain.2011.0035.Peer-Reviewed Original Research
2010
Abnormal functional connectivity of default mode sub-networks in autism spectrum disorder patients
Assaf M, Jagannathan K, Calhoun VD, Miller L, Stevens MC, Sahl R, O'Boyle JG, Schultz RT, Pearlson GD. Abnormal functional connectivity of default mode sub-networks in autism spectrum disorder patients. NeuroImage 2010, 53: 247-256. PMID: 20621638, PMCID: PMC3058935, DOI: 10.1016/j.neuroimage.2010.05.067.Peer-Reviewed Original ResearchDisruptions in Functional Network Connectivity During Alcohol Intoxicated Driving
Rzepecki‐Smith C, Meda SA, Calhoun VD, Stevens MC, Jafri MJ, Astur RS, Pearlson GD. Disruptions in Functional Network Connectivity During Alcohol Intoxicated Driving. Alcohol Clinical And Experimental Research 2010, 34: 479-487. PMID: 20028354, PMCID: PMC2858246, DOI: 10.1111/j.1530-0277.2009.01112.x.Peer-Reviewed Original ResearchConceptsBlood alcohol concentrationInfluence of alcoholFunctional network connectivityBasal gangliaAlcohol intoxicationBrain circuitsMajor public health problemMagnetic resonance imaging studyNormal motor behaviorPublic health problemResonance imaging studyFunctional magnetic resonance imaging studyIndividualized doseImpaired driving behaviorsAlcohol dosesActive doseMotor control functionsHealth problemsImaging studiesFunctional connectivityCerebellar circuitsMotor behaviorSocial drinkersInter-regional connectivityPlacebo
2009
Evidence for Anomalous Network Connectivity during Working Memory Encoding in Schizophrenia: An ICA Based Analysis
Meda SA, Stevens MC, Folley BS, Calhoun VD, Pearlson GD. Evidence for Anomalous Network Connectivity during Working Memory Encoding in Schizophrenia: An ICA Based Analysis. PLOS ONE 2009, 4: e7911. PMID: 19936244, PMCID: PMC2775682, DOI: 10.1371/journal.pone.0007911.Peer-Reviewed Original ResearchConceptsTask accuracyFunctional connectivityPrefrontal cortexNetwork engagementLeft fronto-parietal networkRight dorsolateral prefrontal cortexMemory fMRI paradigmWorking Memory EncodingFronto-parietal networkVentrolateral prefrontal cortexNumerous neuroimaging studiesDorsolateral prefrontal cortexIndependent component analysisAbnormal regional brain activityDefault mode networkBrain network integrationDysfunctional brain regionsPrevious schizophrenia studiesRegional brain activityHippocampus/parahippocampusMemory encodingFMRI taskMemory cognitionMemory performanceFMRI paradigmInvestigation of relationships between fMRI brain networks in the spectral domain using ICA and Granger causality reveals distinct differences between schizophrenia patients and healthy controls
Demirci O, Stevens MC, Andreasen NC, Michael A, Liu J, White T, Pearlson GD, Clark VP, Calhoun VD. Investigation of relationships between fMRI brain networks in the spectral domain using ICA and Granger causality reveals distinct differences between schizophrenia patients and healthy controls. NeuroImage 2009, 46: 419-431. PMID: 19245841, PMCID: PMC2713821, DOI: 10.1016/j.neuroimage.2009.02.014.Peer-Reviewed Original ResearchConceptsFunctional network connectivitySternberg Item Recognition ParadigmTemporal lobe activationBrain networksBrain activation networksCerebral sitesHealthy controlsAuditory oddball taskPsychiatric disordersSchizophrenia patientsControl groupAOD taskCausal relationshipFMRI brain networksTime courseOddball task
2007
A method for functional network connectivity among spatially independent resting-state components in schizophrenia
Jafri MJ, Pearlson GD, Stevens M, Calhoun VD. A method for functional network connectivity among spatially independent resting-state components in schizophrenia. NeuroImage 2007, 39: 1666-1681. PMID: 18082428, PMCID: PMC3164840, DOI: 10.1016/j.neuroimage.2007.11.001.Peer-Reviewed Original ResearchConceptsFunctional network connectivityFunctional connectivityTime courseICA time coursesHealthy controlsMagnetic resonance imaging dataHealthy individualsPatientsBrain disordersBrain regionsState fMRI dataCortical processingSchizophreniaFunctional magnetic resonance imaging (fMRI) dataSpatial independent component analysisSignificant differencesBrain networksComponent time coursesTemporal relationshipCoherent brain regionsBrainFMRI dataCourseImaging dataSeed voxelsBrain network dynamics during error commission
Stevens MC, Kiehl KA, Pearlson GD, Calhoun VD. Brain network dynamics during error commission. Human Brain Mapping 2007, 30: 24-37. PMID: 17979124, PMCID: PMC2669663, DOI: 10.1002/hbm.20478.Peer-Reviewed Original ResearchConceptsError commissionGo/No-Go taskVisual Go/No-Go taskHigher-order cognitive controlFunctional magnetic resonance imaging (fMRI) dataLateral prefrontal cortexPrefrontal brain regionsWhole-brain functional connectivityPregenual cingulate cortexAnterior temporal lobeBrain network dynamicsInferior parietal lobuleAdult healthy participantsBrain functional connectivityCognitive controlIndependent component analysisButton pressHemodynamic activationAffective responsesDevelopmental differencesNeurobiological differencesParietal lobulePrefrontal cortexAnterior cingulateError detection networkFunctional neural networks underlying response inhibition in adolescents and adults
Stevens MC, Kiehl KA, Pearlson GD, Calhoun VD. Functional neural networks underlying response inhibition in adolescents and adults. Behavioural Brain Research 2007, 181: 12-22. PMID: 17467816, PMCID: PMC2266817, DOI: 10.1016/j.bbr.2007.03.023.Peer-Reviewed Original ResearchConceptsResponse inhibition circuitsBehavioral performance changesBrain hemodynamic activityResponse inhibitionFronto-striatal regionsThalamic modulationThalamic connectivityAge-related differencesPremotor cortexHealthy adolescentsGo/No-Go taskNeural circuitsHemodynamic activityEffective connectivity analysisInhibition circuitAdultsFunctional neural networksResponse suppressionAdolescentsConnectivity analysisFirst descriptionInhibitionNetwork engagement