2013
Diffusion Tensor Imaging White Matter Endophenotypes in Patients With Schizophrenia or Psychotic Bipolar Disorder and Their Relatives
Skudlarski P, Schretlen DJ, Thaker GK, Stevens MC, Keshavan MS, Sweeney JA, Tamminga CA, Clementz BA, O’Neil K, Pearlson GD. Diffusion Tensor Imaging White Matter Endophenotypes in Patients With Schizophrenia or Psychotic Bipolar Disorder and Their Relatives. American Journal Of Psychiatry 2013, 170: 886-898. PMID: 23771210, DOI: 10.1176/appi.ajp.2013.12111448.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAnisotropyBipolar DisorderBrainDiffusion Tensor ImagingDominance, CerebralEndophenotypesGenetic Predisposition to DiseaseHumansImage Interpretation, Computer-AssistedLeukoencephalopathiesNerve NetPhenotypePsychiatric Status Rating ScalesReference ValuesSchizophreniaSchizophrenic PsychologyStatistics as TopicConceptsPsychotic bipolar disorderBipolar disorderWhite matter integrityFractional anisotropyComparison subjectsFractional anisotropy decreasesFirst-degree relativesHealthy comparison subjectsLower white matter integrityDiffusion tensorMultiple white matter regionsLower fractional anisotropyWhite matter regionsBipolar-Schizophrenia NetworkHealthy subjectsBipolar relativesProband groupsYoung subjectsBrain regionsDisease specificityFractional anisotropy measuresUnaffected relativesMatter regionsBrain connectivitySchizophrenia
2012
fMRI task parameters influence hemodynamic activity in regions implicated in mental set switching
Witt ST, Stevens MC. fMRI task parameters influence hemodynamic activity in regions implicated in mental set switching. NeuroImage 2012, 65: 139-151. PMID: 23079572, PMCID: PMC3523276, DOI: 10.1016/j.neuroimage.2012.09.072.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAttentionBrainBrain MappingExecutive FunctionFemaleHemodynamicsHumansImage Interpretation, Computer-AssistedMagnetic Resonance ImagingMaleYoung AdultConceptsBrain regionsMagnetic resonance imaging studySecondary visual cortexResonance imaging studyFunctional magnetic resonance imaging studySensorimotor cortexFronto-parietal regionsAnterior prefrontal cortexAnterior cingulateVisual cortexImaging studiesFronto-parietal networkPrefrontal cortexHemodynamic activityCortexBrain activityComplex executive functionsStimulus complexityExecutive functionResponse complexityTrialsNon-switch trialsPrevious studiesOvercoming residual interference in mental set switching: Neural correlates and developmental trajectory
Witt ST, Stevens MC. Overcoming residual interference in mental set switching: Neural correlates and developmental trajectory. NeuroImage 2012, 62: 2055-2064. PMID: 22584223, PMCID: PMC3482401, DOI: 10.1016/j.neuroimage.2012.05.007.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAttentionBrainBrain MappingChildExecutive FunctionFemaleHumansImage Interpretation, Computer-AssistedMagnetic Resonance ImagingMaleNeural PathwaysYoung AdultConceptsHigher taskLower taskFunctional magnetic resonance imaging studySpaced trialsSubsequent stimulus processingBrain regionsMagnetic resonance imaging studyDissociable influencesExecutive controlCognitive setResonance imaging studyNeural correlatesStimulus processingBrain systemsSwitch costsDevelopmental trajectoriesTask typeSet switchingSubcortical motor networksNew tasksInterstimulus intervalPassive decayTaskReaction timeCortical control
2010
Abnormal functional connectivity of default mode sub-networks in autism spectrum disorder patients
Assaf M, Jagannathan K, Calhoun VD, Miller L, Stevens MC, Sahl R, O'Boyle JG, Schultz RT, Pearlson GD. Abnormal functional connectivity of default mode sub-networks in autism spectrum disorder patients. NeuroImage 2010, 53: 247-256. PMID: 20621638, PMCID: PMC3058935, DOI: 10.1016/j.neuroimage.2010.05.067.Peer-Reviewed Original Research
2009
A pilot multivariate parallel ICA study to investigate differential linkage between neural networks and genetic profiles in schizophrenia
Meda SA, Jagannathan K, Gelernter J, Calhoun VD, Liu J, Stevens MC, Pearlson GD. A pilot multivariate parallel ICA study to investigate differential linkage between neural networks and genetic profiles in schizophrenia. NeuroImage 2009, 53: 1007-1015. PMID: 19944766, PMCID: PMC3968678, DOI: 10.1016/j.neuroimage.2009.11.052.Peer-Reviewed Original ResearchMeSH KeywordsAcoustic StimulationBrain MappingBrain-Derived Neurotrophic FactorDopamine Plasma Membrane Transport ProteinsEndophenotypesFemaleGenetic Predisposition to DiseaseGenotypeHumansImage Interpretation, Computer-AssistedMagnetic Resonance ImagingMaleNeural PathwaysPilot ProjectsPolymorphism, Single NucleotideSchizophreniaSerotonin Plasma Membrane Transport ProteinsConceptsDopamine transporterBrain functionNeurotropic factorAuditory oddball taskSchizophrenia patientsSingle nucleotide polymorphismsMultiple risk genesRisk genesOddball taskRelated brain functionsHealthy controlsSchizophrenia risk genesAbnormal activationGenomic factorsTemporal gyrusPatientsTask-relevant regionsSchizophreniaSignificant differencesAttention/Multiple single nucleotide polymorphismsGenetic profilePsychiatric neuroimagingBrainGenotype-phenotype relationships