2023
Age-related, multivariate associations between white matter microstructure and behavioral performance in three executive function domains
Anderson J, Calhoun V, Pearlson G, Hawkins K, Stevens M. Age-related, multivariate associations between white matter microstructure and behavioral performance in three executive function domains. Developmental Cognitive Neuroscience 2023, 64: 101318. PMID: 37875033, PMCID: PMC10618425, DOI: 10.1016/j.dcn.2023.101318.Peer-Reviewed Original ResearchConceptsExecutive function domainsResponse inhibitionWhite matter microstructureLower response inhibitionStructure-cognition relationshipsEF abilitiesBehavioral performanceCognitive imbalanceNeurocognitive testsFunction domainTest performanceYoung adulthoodFractional anisotropyBrain changesAge 12Young adultsSS performanceWhite matter FA valuesGreater relianceWhite matter changesWhite matter microstructural differencesSubjects ages 12White matter skeletonIndependent componentsMultivariate associations
2013
White matter abnormalities in adolescents with major depressive disorder
Bessette KL, Nave AM, Caprihan A, Stevens MC. White matter abnormalities in adolescents with major depressive disorder. Brain Imaging And Behavior 2013, 8: 531-541. PMID: 24242685, DOI: 10.1007/s11682-013-9274-8.Peer-Reviewed Original ResearchConceptsMajor depressive disorderWhite matter abnormalitiesDiffusion tensor imagingDepressive disorderFrontal lobeWhole brainRegional white matter abnormalitiesRight thalamic radiationOlder depressed patientsTract-based spatial statisticsCorpus callosum genuFrontal lobe tractsFractional anisotropy valuesLower FAAbnormal white matter microstructureInferior longitudinal fasciculusWhite matter connectionsWhite matter microstructureInternal capsuleExternal capsuleFA abnormalitiesDepressed patientsHealthy controlsAdolescents ages 13Posterior limbDTI-measured white matter abnormalities in adolescents with Conduct Disorder
Haney-Caron E, Caprihan A, Stevens MC. DTI-measured white matter abnormalities in adolescents with Conduct Disorder. Journal Of Psychiatric Research 2013, 48: 111-120. PMID: 24139595, PMCID: PMC3863548, DOI: 10.1016/j.jpsychires.2013.09.015.Peer-Reviewed Original ResearchConceptsFractional anisotropyAxial diffusivityWhite matter microstructureMicrostructural abnormalitiesLong-range white matter connectionsWhite matter microstructural abnormalitiesWhite matter abnormalitiesDiffusion tensor imaging (DTI) findingsAnatomical connectivity abnormalitiesLower fractional anisotropySuperior corona radiataAbnormal white matter microstructureBrain white matter microstructureDifferent brain regionsWhite matter connectionsTemporal lobe regionsFronto-occipital fasciculusTwo-sample t-testFunctional neuroimaging studiesCD ageCD adolescentsMajor white matterImaging findingsRadial diffusivity measurementsStudy groupDiffusion Tensor Imaging White Matter Endophenotypes in Patients With Schizophrenia or Psychotic Bipolar Disorder and Their Relatives
Skudlarski P, Schretlen DJ, Thaker GK, Stevens MC, Keshavan MS, Sweeney JA, Tamminga CA, Clementz BA, O’Neil K, Pearlson GD. Diffusion Tensor Imaging White Matter Endophenotypes in Patients With Schizophrenia or Psychotic Bipolar Disorder and Their Relatives. American Journal Of Psychiatry 2013, 170: 886-898. PMID: 23771210, DOI: 10.1176/appi.ajp.2013.12111448.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAnisotropyBipolar DisorderBrainDiffusion Tensor ImagingDominance, CerebralEndophenotypesGenetic Predisposition to DiseaseHumansImage Interpretation, Computer-AssistedLeukoencephalopathiesNerve NetPhenotypePsychiatric Status Rating ScalesReference ValuesSchizophreniaSchizophrenic PsychologyStatistics as TopicConceptsPsychotic bipolar disorderBipolar disorderWhite matter integrityFractional anisotropyComparison subjectsFractional anisotropy decreasesFirst-degree relativesHealthy comparison subjectsLower white matter integrityDiffusion tensorMultiple white matter regionsLower fractional anisotropyWhite matter regionsBipolar-Schizophrenia NetworkHealthy subjectsBipolar relativesProband groupsYoung subjectsBrain regionsDisease specificityFractional anisotropy measuresUnaffected relativesMatter regionsBrain connectivitySchizophrenia
2009
Age-related cognitive gains are mediated by the effects of white matter development on brain network integration
Stevens MC, Skudlarski P, Pearlson GD, Calhoun VD. Age-related cognitive gains are mediated by the effects of white matter development on brain network integration. NeuroImage 2009, 48: 738-746. PMID: 19577651, PMCID: PMC2753497, DOI: 10.1016/j.neuroimage.2009.06.065.Peer-Reviewed Original ResearchConceptsCognitive controlBrain activityWhite matter developmentDevelopmental cognitive neuroscienceExecutive cognitive abilityBrain network integrationWhite matter coherenceCognitive neuroscienceCognitive abilitiesResponse inhibitionAdolescent developmentCognitive gainsBehavioral performanceSpecific white matter regionsFunctional integrationAge-related changesFirst multimodalBehavioral controlFunctional connectivityMaturational factorsBrain regionsLocal processingNetwork integrationFunctional circuitsNeuroscience