2023
Age-related, multivariate associations between white matter microstructure and behavioral performance in three executive function domains
Anderson J, Calhoun V, Pearlson G, Hawkins K, Stevens M. Age-related, multivariate associations between white matter microstructure and behavioral performance in three executive function domains. Developmental Cognitive Neuroscience 2023, 64: 101318. PMID: 37875033, PMCID: PMC10618425, DOI: 10.1016/j.dcn.2023.101318.Peer-Reviewed Original ResearchConceptsExecutive function domainsResponse inhibitionWhite matter microstructureLower response inhibitionStructure-cognition relationshipsEF abilitiesBehavioral performanceCognitive imbalanceNeurocognitive testsFunction domainTest performanceYoung adulthoodFractional anisotropyBrain changesAge 12Young adultsSS performanceWhite matter FA valuesGreater relianceWhite matter changesWhite matter microstructural differencesSubjects ages 12White matter skeletonIndependent componentsMultivariate associations
2013
Hoarding disorder and obsessive–compulsive disorder show different patterns of neural activity during response inhibition
Tolin DF, Witt ST, Stevens MC. Hoarding disorder and obsessive–compulsive disorder show different patterns of neural activity during response inhibition. Psychiatry Research 2013, 221: 142-148. PMID: 24389161, PMCID: PMC3946244, DOI: 10.1016/j.pscychresns.2013.11.009.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderGo/NoGo taskFunctional magnetic resonance imagingOCD patientsHD patientsResponse inhibitionNoGo taskHealthy controlsGo/NoGo task performanceDistinct neural underpinningsRight orbitofrontal gyrusErrors of commissionNeural underpinningsOrbitofrontal activationTask performanceCorrect rejectsMagnetic resonance imagingHemodynamic activityFrontal hypoactivityNeural activityOrbitofrontal gyrusBehavioral dataHemodynamic responsePatientsPreliminary evidenceError processing in current and former cocaine users
Castelluccio BC, Meda SA, Muska CE, Stevens MC, Pearlson GD. Error processing in current and former cocaine users. Brain Imaging And Behavior 2013, 8: 87-96. PMID: 23949893, PMCID: PMC3925762, DOI: 10.1007/s11682-013-9247-y.Peer-Reviewed Original ResearchConceptsFormer cocaine usersError processingSupramarginal gyrusCocaine usersBOLD responseRight inferior parietal lobuleAspects of impulsivityAbstinent cocaine usersCocaine abuse/dependenceInferior parietal lobuleCocaine-dependent individualsCurrent cocaine usersCognitive compensationNeural differencesPrepotent responsesResponse inhibitionAbuse/dependenceCorrect rejectionsSpecific deficitsBOLD activityTrait measuresMaladaptive behaviorsParietal lobuleAddictive behaviorsNeural activityA large scale (N=102) functional neuroimaging study of response inhibition in a Go/NoGo task
Steele VR, Aharoni E, Munro GE, Calhoun VD, Nyalakanti P, Stevens MC, Pearlson G, Kiehl KA. A large scale (N=102) functional neuroimaging study of response inhibition in a Go/NoGo task. Behavioural Brain Research 2013, 256: 529-536. PMID: 23756137, PMCID: PMC4437665, DOI: 10.1016/j.bbr.2013.06.001.Peer-Reviewed Original ResearchConceptsSuccessful response inhibitionGo/NoGo taskResponse inhibitionUnsuccessful response inhibitionMagnetic resonance imaging studySupplementary motor areaResonance imaging studyFunctional magnetic resonance imaging studyInferior parietal lobuleNoGo taskInferior prefrontal regionsHealthy adult participantsBasal gangliaInferior frontal gyrusHemodynamic responseMotor areaAnterior cingulateImaging studiesParietal lobuleFronto-parietal networkHemodynamic activityFrontal gyrusFrontostriatal regionsSmall sample studiesPrefrontal regionsInfluence of Alcohol Use on Neural Response to Go/No-Go Task in College Drinkers
Ahmadi A, Pearlson GD, Meda SA, Dager A, Potenza MN, Rosen R, Austad CS, Raskin SA, Fallahi CR, Tennen H, Wood RM, Stevens MC. Influence of Alcohol Use on Neural Response to Go/No-Go Task in College Drinkers. Neuropsychopharmacology 2013, 38: 2197-2208. PMID: 23670589, PMCID: PMC3773670, DOI: 10.1038/npp.2013.119.Peer-Reviewed Original ResearchConceptsSupplementary motor areaHeavy drinkersLight drinkersCollege-age drinkersAlcohol useResponse inhibitionBlood oxygen level-dependent (BOLD) responseHeavy alcohol drinkersImportant risk factorBilateral middle frontal gyrusAlcohol use disorderBrain activityAnterior cingulate cortexGreater BOLD responseLevel-dependent responsesMiddle frontal gyrusSuperior temporal gyrusImpaired response inhibitionAlcohol drinkersRisk factorsResponse inhibition taskRight hippocampusMotor areaWarrants additional investigationBilateral parietal lobules
2011
Pharmacotherapy impacts functional connectivity among affective circuits during response inhibition in pediatric mania
Pavuluri MN, Ellis JA, Wegbreit E, Passarotti AM, Stevens MC. Pharmacotherapy impacts functional connectivity among affective circuits during response inhibition in pediatric mania. Behavioural Brain Research 2011, 226: 493-503. PMID: 22004983, PMCID: PMC3253527, DOI: 10.1016/j.bbr.2011.10.003.Peer-Reviewed Original ResearchConceptsPediatric bipolar disorderAffective circuitsFunctional connectivityResponse inhibitionFMRI taskEmotional influencesAmygdala activityBehavioral inhibitionTask performanceTrait deficitAmygdala connectivityNeural operationsPediatric maniaNormative comparisonsSubgenual ACCFMRI trialAnti-epileptic medicationsMotor responseGreater engagementDifferential influenceStop signalBehavioral differencesCurrent studyDivalproex groupRisperidone group
2009
Age-related cognitive gains are mediated by the effects of white matter development on brain network integration
Stevens MC, Skudlarski P, Pearlson GD, Calhoun VD. Age-related cognitive gains are mediated by the effects of white matter development on brain network integration. NeuroImage 2009, 48: 738-746. PMID: 19577651, PMCID: PMC2753497, DOI: 10.1016/j.neuroimage.2009.06.065.Peer-Reviewed Original ResearchConceptsCognitive controlBrain activityWhite matter developmentDevelopmental cognitive neuroscienceExecutive cognitive abilityBrain network integrationWhite matter coherenceCognitive neuroscienceCognitive abilitiesResponse inhibitionAdolescent developmentCognitive gainsBehavioral performanceSpecific white matter regionsFunctional integrationAge-related changesFirst multimodalBehavioral controlFunctional connectivityMaturational factorsBrain regionsLocal processingNetwork integrationFunctional circuitsNeuroscience
2007
Functional neural networks underlying response inhibition in adolescents and adults
Stevens MC, Kiehl KA, Pearlson GD, Calhoun VD. Functional neural networks underlying response inhibition in adolescents and adults. Behavioural Brain Research 2007, 181: 12-22. PMID: 17467816, PMCID: PMC2266817, DOI: 10.1016/j.bbr.2007.03.023.Peer-Reviewed Original ResearchConceptsResponse inhibition circuitsBehavioral performance changesBrain hemodynamic activityResponse inhibitionFronto-striatal regionsThalamic modulationThalamic connectivityAge-related differencesPremotor cortexHealthy adolescentsGo/No-Go taskNeural circuitsHemodynamic activityEffective connectivity analysisInhibition circuitAdultsFunctional neural networksResponse suppressionAdolescentsConnectivity analysisFirst descriptionInhibitionNetwork engagement