2013
Time course of recovery showing initial prefrontal cortex changes at 16 weeks, extending to subcortical changes by 3 years in pediatric bipolar disorder
Yang H, Lu LH, Wu M, Stevens M, Wegbreit E, Fitzgerald J, Levitan B, Shankman S, Pavuluri MN. Time course of recovery showing initial prefrontal cortex changes at 16 weeks, extending to subcortical changes by 3 years in pediatric bipolar disorder. Journal Of Affective Disorders 2013, 150: 571-577. PMID: 23517886, PMCID: PMC3745513, DOI: 10.1016/j.jad.2013.02.007.Peer-Reviewed Original ResearchConceptsDorsal lateral prefrontal cortexPediatric bipolar disorderVentral lateral prefrontal cortexAnterior cingulate cortexHealthy controlsBipolar disorderLateral prefrontal cortexCortical regionsPrefrontal cortexRight dorsal lateral prefrontal cortexBilateral anterior cingulate cortexVentral cortical regionsFronto-limbic circuitsGreater activationPrefrontal cortex changesPresent findingsProlonged lengthMedication algorithmSubcortical changesUnmedicated patientsFronto-striatalPharmacological interventionsPBD groupSubcortical activityCingulate cortex
2012
Reduced Functional Connectivity of Prefrontal Regions and Amygdala Within Affect and Working Memory Networks in Pediatric Bipolar Disorder
Passarotti AM, Ellis J, Wegbreit E, Stevens MC, Pavuluri MN. Reduced Functional Connectivity of Prefrontal Regions and Amygdala Within Affect and Working Memory Networks in Pediatric Bipolar Disorder. Brain Connectivity 2012, 2: 320-334. PMID: 23035965, PMCID: PMC3621331, DOI: 10.1089/brain.2012.0089.Peer-Reviewed Original ResearchConceptsVentrolateral prefrontal cortexPediatric bipolar disorderRight ventrolateral prefrontal cortexWorking Memory NetworkFunctional connectivityMemory taskDorsolateral PFCBrain networksRight amygdalaMemory networkEmotion processing regionsEmotion regulation regionsDifferential functional connectivityFunctional magnetic resonanceBilateral temporal regionsConnected brain networksRegulation regionRegional functional connectivityNeutral facesEmotion processingCognitive processesEmotion evaluationPrefrontal regionsProcessing regionsBipolar disorder
2011
Amygdala Functional Connectivity Predicts Pharmacotherapy Outcome in Pediatric Bipolar Disorder
Wegbreit E, Ellis JA, Nandam A, Fitzgerald JM, Passarotti AM, Pavuluri MN, Stevens MC. Amygdala Functional Connectivity Predicts Pharmacotherapy Outcome in Pediatric Bipolar Disorder. Brain Connectivity 2011, 1: 411-422. PMID: 22432455, PMCID: PMC3604767, DOI: 10.1089/brain.2011.0035.Peer-Reviewed Original ResearchPharmacotherapy impacts functional connectivity among affective circuits during response inhibition in pediatric mania
Pavuluri MN, Ellis JA, Wegbreit E, Passarotti AM, Stevens MC. Pharmacotherapy impacts functional connectivity among affective circuits during response inhibition in pediatric mania. Behavioural Brain Research 2011, 226: 493-503. PMID: 22004983, PMCID: PMC3253527, DOI: 10.1016/j.bbr.2011.10.003.Peer-Reviewed Original ResearchConceptsPediatric bipolar disorderAffective circuitsFunctional connectivityResponse inhibitionFMRI taskEmotional influencesAmygdala activityBehavioral inhibitionTask performanceTrait deficitAmygdala connectivityNeural operationsPediatric maniaNormative comparisonsSubgenual ACCFMRI trialAnti-epileptic medicationsMotor responseGreater engagementDifferential influenceStop signalBehavioral differencesCurrent studyDivalproex groupRisperidone group