2022
The thalamus and its subnuclei—a gateway to obsessive-compulsive disorder
Weeland CJ, Kasprzak S, de Joode NT, Abe Y, Alonso P, Ameis SH, Anticevic A, Arnold PD, Balachander S, Banaj N, Bargallo N, Batistuzzo MC, Benedetti F, Beucke JC, Bollettini I, Brecke V, Brem S, Cappi C, Cheng Y, Cho KIK, Costa DLC, Dallaspezia S, Denys D, Eng GK, Ferreira S, Feusner JD, Fontaine M, Fouche JP, Grazioplene RG, Gruner P, He M, Hirano Y, Hoexter MQ, Huyser C, Hu H, Jaspers-Fayer F, Kathmann N, Kaufmann C, Kim M, Koch K, Bin Kwak Y, Kwon JS, Lazaro L, Li CR, Lochner C, Marsh R, Martínez-Zalacaín I, Mataix-Cols D, Menchón JM, Minnuzi L, Moreira PS, Morgado P, Nakagawa A, Nakamae T, Narayanaswamy JC, Nurmi EL, Ortiz AE, Pariente JC, Piacentini J, Picó-Pérez M, Piras F, Piras F, Pittenger C, Reddy YCJ, Rodriguez-Manrique D, Sakai Y, Shimizu E, Shivakumar V, Simpson HB, Soreni N, Soriano-Mas C, Sousa N, Spalletta G, Stern ER, Stevens MC, Stewart SE, Szeszko PR, Takahashi J, Tanamatis T, Tang J, Thorsen AL, Tolin D, van der Werf YD, van Marle H, van Wingen GA, Vecchio D, Venkatasubramanian G, Walitza S, Wang J, Wang Z, Watanabe A, Wolters LH, Xu X, Yun JY, Zhao Q, White T, Thompson P, Stein D, van den Heuvel O, Vriend C. The thalamus and its subnuclei—a gateway to obsessive-compulsive disorder. Translational Psychiatry 2022, 12: 70. PMID: 35190533, PMCID: PMC8861046, DOI: 10.1038/s41398-022-01823-2.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderMagnetic resonance imagingThalamic volumeOCD patientsThalamic subregionsT1-weighted brain magnetic resonance imagingBrain magnetic resonance imagingClinical-level symptomsLarger thalamic volumesPediatric OCD patientsAdult OCD patientsSeparate multiple linear regression modelsVolumetric group differencesThalamus sizeMedicated patientsAdolescent patientsAnterior thalamusHealthy controlsSubregional volumesGeneral populationMedication statusMultiple comparison correctionPatientsResonance imagingIntracranial volume
2013
Hoarding disorder and obsessive–compulsive disorder show different patterns of neural activity during response inhibition
Tolin DF, Witt ST, Stevens MC. Hoarding disorder and obsessive–compulsive disorder show different patterns of neural activity during response inhibition. Psychiatry Research 2013, 221: 142-148. PMID: 24389161, PMCID: PMC3946244, DOI: 10.1016/j.pscychresns.2013.11.009.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderGo/NoGo taskFunctional magnetic resonance imagingOCD patientsHD patientsResponse inhibitionNoGo taskHealthy controlsGo/NoGo task performanceDistinct neural underpinningsRight orbitofrontal gyrusErrors of commissionNeural underpinningsOrbitofrontal activationTask performanceCorrect rejectsMagnetic resonance imagingHemodynamic activityFrontal hypoactivityNeural activityOrbitofrontal gyrusBehavioral dataHemodynamic responsePatientsPreliminary evidenceWhite matter abnormalities in adolescents with major depressive disorder
Bessette KL, Nave AM, Caprihan A, Stevens MC. White matter abnormalities in adolescents with major depressive disorder. Brain Imaging And Behavior 2013, 8: 531-541. PMID: 24242685, DOI: 10.1007/s11682-013-9274-8.Peer-Reviewed Original ResearchConceptsMajor depressive disorderWhite matter abnormalitiesDiffusion tensor imagingDepressive disorderFrontal lobeWhole brainRegional white matter abnormalitiesRight thalamic radiationOlder depressed patientsTract-based spatial statisticsCorpus callosum genuFrontal lobe tractsFractional anisotropy valuesLower FAAbnormal white matter microstructureInferior longitudinal fasciculusWhite matter connectionsWhite matter microstructureInternal capsuleExternal capsuleFA abnormalitiesDepressed patientsHealthy controlsAdolescents ages 13Posterior limbTime course of recovery showing initial prefrontal cortex changes at 16 weeks, extending to subcortical changes by 3 years in pediatric bipolar disorder
Yang H, Lu LH, Wu M, Stevens M, Wegbreit E, Fitzgerald J, Levitan B, Shankman S, Pavuluri MN. Time course of recovery showing initial prefrontal cortex changes at 16 weeks, extending to subcortical changes by 3 years in pediatric bipolar disorder. Journal Of Affective Disorders 2013, 150: 571-577. PMID: 23517886, PMCID: PMC3745513, DOI: 10.1016/j.jad.2013.02.007.Peer-Reviewed Original ResearchConceptsDorsal lateral prefrontal cortexPediatric bipolar disorderVentral lateral prefrontal cortexAnterior cingulate cortexHealthy controlsBipolar disorderLateral prefrontal cortexCortical regionsPrefrontal cortexRight dorsal lateral prefrontal cortexBilateral anterior cingulate cortexVentral cortical regionsFronto-limbic circuitsGreater activationPrefrontal cortex changesPresent findingsProlonged lengthMedication algorithmSubcortical changesUnmedicated patientsFronto-striatalPharmacological interventionsPBD groupSubcortical activityCingulate cortex
2012
RETRACTED: Where, when, how high, and how long? The hemodynamics of emotional response in psychotropic-naïve patients with adolescent bipolar disorder.
Wegbreit E, Passarotti AM, Ellis JA, Wu M, Witowski N, Fitzgerald JM, Stevens MC, Pavuluri MN. RETRACTED: Where, when, how high, and how long? The hemodynamics of emotional response in psychotropic-naïve patients with adolescent bipolar disorder. Journal Of Affective Disorders 2012, 147: 304-311. PMID: 23261134, PMCID: PMC3606663, DOI: 10.1016/j.jad.2012.11.025.Peer-Reviewed Original ResearchConceptsFearful facesPrefrontal cortexNeutral facesRight dorsolateral prefrontal cortexEmotion-attention interactionsEnhanced neural processingVentrolateral prefrontal cortexEmotional processing regionsDorsolateral prefrontal cortexAdolescent bipolar disorderProbe taskEmotional facesPrefrontal activityNeural processingSpaced stimuliABD groupEmotional responsesProcessing regionsBilateral amygdalaDisorder exhibitMixed mood statesMood statesHealthy controlsNeural activityBipolar disorder exhibitA large scale multivariate parallel ICA method reveals novel imaging–genetic relationships for Alzheimer's disease in the ADNI cohort
Meda SA, Narayanan B, Liu J, Perrone-Bizzozero NI, Stevens MC, Calhoun VD, Glahn DC, Shen L, Risacher SL, Saykin AJ, Pearlson GD. A large scale multivariate parallel ICA method reveals novel imaging–genetic relationships for Alzheimer's disease in the ADNI cohort. NeuroImage 2012, 60: 1608-1621. PMID: 22245343, PMCID: PMC3312985, DOI: 10.1016/j.neuroimage.2011.12.076.Peer-Reviewed Original ResearchMeSH KeywordsAgedAlzheimer DiseaseBrainCanadaCohort StudiesData Interpretation, StatisticalFemaleGenetic Predisposition to DiseaseHumansMagnetic Resonance ImagingMaleMultivariate AnalysisPolymorphism, Single NucleotidePrevalencePrincipal Component AnalysisReproducibility of ResultsSensitivity and SpecificityUnited StatesConceptsLate-onset Alzheimer's diseaseMagnetic resonance imagingAlzheimer's diseaseOnset Alzheimer's diseaseAlzheimer's Disease Neuroimaging Initiative (ADNI) cohortElderly healthy controlsAmnestic mild cognitive impairmentDifferent brain regionsMild cognitive impairmentStructural MRI scansHealthy controlsCardiovascular diseaseInitiative cohortMRI scansPathologic processesCognitive impairmentResonance imagingBrain regionsSingle nucleotide polymorphism (SNP) variantsCaucasian adultsSubject cohortDiseasePhysiologic pathwaysCohortPolymorphism variants
2011
Amygdala Functional Connectivity Predicts Pharmacotherapy Outcome in Pediatric Bipolar Disorder
Wegbreit E, Ellis JA, Nandam A, Fitzgerald JM, Passarotti AM, Pavuluri MN, Stevens MC. Amygdala Functional Connectivity Predicts Pharmacotherapy Outcome in Pediatric Bipolar Disorder. Brain Connectivity 2011, 1: 411-422. PMID: 22432455, PMCID: PMC3604767, DOI: 10.1089/brain.2011.0035.Peer-Reviewed Original Research
2009
A pilot multivariate parallel ICA study to investigate differential linkage between neural networks and genetic profiles in schizophrenia
Meda SA, Jagannathan K, Gelernter J, Calhoun VD, Liu J, Stevens MC, Pearlson GD. A pilot multivariate parallel ICA study to investigate differential linkage between neural networks and genetic profiles in schizophrenia. NeuroImage 2009, 53: 1007-1015. PMID: 19944766, PMCID: PMC3968678, DOI: 10.1016/j.neuroimage.2009.11.052.Peer-Reviewed Original ResearchMeSH KeywordsAcoustic StimulationBrain MappingBrain-Derived Neurotrophic FactorDopamine Plasma Membrane Transport ProteinsEndophenotypesFemaleGenetic Predisposition to DiseaseGenotypeHumansImage Interpretation, Computer-AssistedMagnetic Resonance ImagingMaleNeural PathwaysPilot ProjectsPolymorphism, Single NucleotideSchizophreniaSerotonin Plasma Membrane Transport ProteinsConceptsDopamine transporterBrain functionNeurotropic factorAuditory oddball taskSchizophrenia patientsSingle nucleotide polymorphismsMultiple risk genesRisk genesOddball taskRelated brain functionsHealthy controlsSchizophrenia risk genesAbnormal activationGenomic factorsTemporal gyrusPatientsTask-relevant regionsSchizophreniaSignificant differencesAttention/Multiple single nucleotide polymorphismsGenetic profilePsychiatric neuroimagingBrainGenotype-phenotype relationshipsInvestigation of relationships between fMRI brain networks in the spectral domain using ICA and Granger causality reveals distinct differences between schizophrenia patients and healthy controls
Demirci O, Stevens MC, Andreasen NC, Michael A, Liu J, White T, Pearlson GD, Clark VP, Calhoun VD. Investigation of relationships between fMRI brain networks in the spectral domain using ICA and Granger causality reveals distinct differences between schizophrenia patients and healthy controls. NeuroImage 2009, 46: 419-431. PMID: 19245841, PMCID: PMC2713821, DOI: 10.1016/j.neuroimage.2009.02.014.Peer-Reviewed Original ResearchConceptsFunctional network connectivitySternberg Item Recognition ParadigmTemporal lobe activationBrain networksBrain activation networksCerebral sitesHealthy controlsAuditory oddball taskPsychiatric disordersSchizophrenia patientsControl groupAOD taskCausal relationshipFMRI brain networksTime courseOddball task
2007
A method for functional network connectivity among spatially independent resting-state components in schizophrenia
Jafri MJ, Pearlson GD, Stevens M, Calhoun VD. A method for functional network connectivity among spatially independent resting-state components in schizophrenia. NeuroImage 2007, 39: 1666-1681. PMID: 18082428, PMCID: PMC3164840, DOI: 10.1016/j.neuroimage.2007.11.001.Peer-Reviewed Original ResearchConceptsFunctional network connectivityFunctional connectivityTime courseICA time coursesHealthy controlsMagnetic resonance imaging dataHealthy individualsPatientsBrain disordersBrain regionsState fMRI dataCortical processingSchizophreniaFunctional magnetic resonance imaging (fMRI) dataSpatial independent component analysisSignificant differencesBrain networksComponent time coursesTemporal relationshipCoherent brain regionsBrainFMRI dataCourseImaging dataSeed voxels