2021
Relating neural processing of reward and loss prospect to risky decision-making in individuals with and without gambling disorder
Balodis I, Linnet J, Arshad F, Worhunsky P, Stevens M, Pearlson G, Potenza M. Relating neural processing of reward and loss prospect to risky decision-making in individuals with and without gambling disorder. 2021, 97-113. DOI: 10.4324/9781003140450-7.ChaptersMonetary incentive delay taskIowa Gambling TaskIncentive delay taskGambling disorderAnticipatory processingIGT scoresIGT performanceDelay taskIowa Gambling Task performanceProspect of rewardDecision-making impairmentsGambling Task performanceVentromedial prefrontal cortexDecision-making taskWhole-brain correlationFronto-striatal activityHC groupVentral striatum/Healthy control participantsTotal IGT scoreAnterior cingulate regionsGambling TaskNeural processesNeural processingTask performance
2018
Quality of life in patients with hoarding disorder
Tolin DF, Das A, Hallion LS, Levy HC, Wootton BM, Stevens MC. Quality of life in patients with hoarding disorder. Journal Of Obsessive-Compulsive And Related Disorders 2018, 21: 55-59. PMID: 31595215, PMCID: PMC6783256, DOI: 10.1016/j.jocrd.2018.12.003.Peer-Reviewed Original ResearchRole limitationsGeneral healthAffective symptomsSex-matched healthy control participantsPoorer health-related QoLHC participantsForm Health SurveyHealth-related QoLHealth-related qualityMedical Outcomes StudySocial functioningQuality of lifeComorbid affective symptomsHealthy control participantsEmotional problemsHD symptom severitySF-36Primary diagnosisHealth SurveyLower QoLOutcome studiesQOL domainsSymptom severityBattery of questionnairesPatientsValidation of a Behavioral Measure of Acquiring and Discarding in Hoarding Disorder
Levy HC, Stevens MC, Tolin DF. Validation of a Behavioral Measure of Acquiring and Discarding in Hoarding Disorder. Journal Of Psychopathology And Behavioral Assessment 2018, 41: 135-143. PMID: 31105379, PMCID: PMC6516472, DOI: 10.1007/s10862-018-9701-7.Peer-Reviewed Original ResearchCognitive behavioral therapyHealthy control participantsBehavioral measuresHD symptomsLonger response timesHoarding DisorderTreatment completersComputer taskEvidence-based assessmentControl participantsConvergent validityCore featuresResponse timeBehavioral assessmentSimulated decisionsMore itemsTreatment-related changesTaskHC groupReaction timeSex-matched healthy control participantsCurrent studySubset of patientsItemsDisordersHoarding disorder and difficulties in emotion regulation
Tolin DF, Levy HC, Wootton BM, Hallion LS, Stevens MC. Hoarding disorder and difficulties in emotion regulation. Journal Of Obsessive-Compulsive And Related Disorders 2018, 16: 98-103. PMID: 30828541, PMCID: PMC6391883, DOI: 10.1016/j.jocrd.2018.01.006.Peer-Reviewed Original ResearchEmotion regulationSelf-reported deficitsGender-matched healthy control participantsGoal-directed cognitionSelf-report measuresHealthy control participantsDERS subscalesEmotional clarityER deficitsEmotional responsesControl participantsDERSAnxietyHC groupBaseline depressionDeficitsHD groupDepressionDiagnostic assessmentParticipantsAdult outpatientsDifficultiesCognitionDisordersHigh levels
2016
Neurofunctional Reward Processing Changes in Cocaine Dependence During Recovery
Balodis IM, Kober H, Worhunsky PD, Stevens MC, Pearlson GD, Carroll KM, Potenza MN. Neurofunctional Reward Processing Changes in Cocaine Dependence During Recovery. Neuropsychopharmacology 2016, 41: 2112-2121. PMID: 26792441, PMCID: PMC4908642, DOI: 10.1038/npp.2016.11.Peer-Reviewed Original ResearchConceptsLeft inferior frontal gyrus activityCD participantsNegative urine screensReward/loss processingHealthy control participantsReward processingMeaningful outcome indicatorsDopamine-innervated regionsFunctional magnetic resonanceInferior frontal gyrus activityCD outpatientsTest-retest resultsPrefrontal cortex activityVentromedial prefrontal cortex activityUrine screensNeurofunctional alterationsVentral striatal activityCD groupNeurofunctional changesLong-term recoveryDrug useNeurobiological changesCocaine abstinenceCocaine dependenceStriatal activity
2012
Neural mechanisms of cognitive behavioral therapy response in Hoarding Disorder: A pilot study
Tolin D, Stevens M, Nave A, Villavicencio A, Morrison S. Neural mechanisms of cognitive behavioral therapy response in Hoarding Disorder: A pilot study. Journal Of Obsessive-Compulsive And Related Disorders 2012, 1: 180-188. DOI: 10.1016/j.jocrd.2012.04.001.Peer-Reviewed Original ResearchCognitive behavioral therapyMedial frontal gyrusFrontal gyrusHemodynamic activityManualized group cognitive behavioral therapyCognitive behavioral therapy responsePosterior cingulateFunctional magnetic resonance imaging (fMRI) taskGroup cognitive behavioral therapyRight superior temporal gyrusDecision-making taskInsula/putamenRight posterior hippocampusSuperior temporal gyrusHealthy control participantsParietal lobe regionsHippocampus/parahippocampusNeural functionHoarding DisorderNeural mechanismsBehavioral therapyTemporal gyrusPosterior hippocampusHC participantsLobe regionsMultiple resting state network functional connectivity abnormalities in mild traumatic brain injury
Stevens MC, Lovejoy D, Kim J, Oakes H, Kureshi I, Witt ST. Multiple resting state network functional connectivity abnormalities in mild traumatic brain injury. Brain Imaging And Behavior 2012, 6: 293-318. PMID: 22555821, DOI: 10.1007/s11682-012-9157-4.Peer-Reviewed Original ResearchConceptsTraumatic brain injuryMild traumatic brain injuryMild TBI patientsFunctional connectivity abnormalitiesTBI patientsBrain injuryConnectivity abnormalitiesFunctional connectivitySevere traumatic brain injuryWhite matter microstructural damagePostconcussive symptom severityWhole-brain functional connectivityFunctional connectivity deficitsCompensatory neural processesBrain networksBrain functional connectivityHealthy control participantsVoxelwise group comparisonsIntracerebral injuryNeurobiological sequelaeConnectivity deficitsAnterior cingulateBrain regionsSymptom severityAnatomical connectivity