2013
A large scale (N=102) functional neuroimaging study of response inhibition in a Go/NoGo task
Steele VR, Aharoni E, Munro GE, Calhoun VD, Nyalakanti P, Stevens MC, Pearlson G, Kiehl KA. A large scale (N=102) functional neuroimaging study of response inhibition in a Go/NoGo task. Behavioural Brain Research 2013, 256: 529-536. PMID: 23756137, PMCID: PMC4437665, DOI: 10.1016/j.bbr.2013.06.001.Peer-Reviewed Original ResearchConceptsSuccessful response inhibitionGo/NoGo taskResponse inhibitionUnsuccessful response inhibitionMagnetic resonance imaging studySupplementary motor areaResonance imaging studyFunctional magnetic resonance imaging studyInferior parietal lobuleNoGo taskInferior prefrontal regionsHealthy adult participantsBasal gangliaInferior frontal gyrusHemodynamic responseMotor areaAnterior cingulateImaging studiesParietal lobuleFronto-parietal networkHemodynamic activityFrontal gyrusFrontostriatal regionsSmall sample studiesPrefrontal regionsIs Aberrant Functional Connectivity A Psychosis Endophenotype? A Resting State Functional Magnetic Resonance Imaging Study
Khadka S, Meda SA, Stevens MC, Glahn DC, Calhoun VD, Sweeney JA, Tamminga CA, Keshavan MS, O’Neil K, Schretlen D, Pearlson GD. Is Aberrant Functional Connectivity A Psychosis Endophenotype? A Resting State Functional Magnetic Resonance Imaging Study. Biological Psychiatry 2013, 74: 458-466. PMID: 23746539, PMCID: PMC3752322, DOI: 10.1016/j.biopsych.2013.04.024.Peer-Reviewed Original ResearchConceptsPsychotic bipolar probandsNegative Syndrome Scale (PANSS) negative scoresState functional magnetic resonance imaging studyFunctional connectivityState functional magnetic resonanceBipolar disorder shareBrain connectivity abnormalitiesPosterior default mode networkSchizophrenia probandsMagnetic resonance imaging studyRespective first-degree relativesAberrant functional connectivityBipolar probandsFirst-degree relativesGroup differencesPsychosis endophenotypesNegative Syndrome ScaleResonance imaging studyFunctional magnetic resonance imaging studyDefault mode networkFunctional magnetic resonanceFunctional connectivity measures
2012
fMRI task parameters influence hemodynamic activity in regions implicated in mental set switching
Witt ST, Stevens MC. fMRI task parameters influence hemodynamic activity in regions implicated in mental set switching. NeuroImage 2012, 65: 139-151. PMID: 23079572, PMCID: PMC3523276, DOI: 10.1016/j.neuroimage.2012.09.072.Peer-Reviewed Original ResearchConceptsBrain regionsMagnetic resonance imaging studySecondary visual cortexResonance imaging studyFunctional magnetic resonance imaging studySensorimotor cortexFronto-parietal regionsAnterior prefrontal cortexAnterior cingulateVisual cortexImaging studiesFronto-parietal networkPrefrontal cortexHemodynamic activityCortexBrain activityComplex executive functionsStimulus complexityExecutive functionResponse complexityTrialsNon-switch trialsPrevious studiesOvercoming residual interference in mental set switching: Neural correlates and developmental trajectory
Witt ST, Stevens MC. Overcoming residual interference in mental set switching: Neural correlates and developmental trajectory. NeuroImage 2012, 62: 2055-2064. PMID: 22584223, PMCID: PMC3482401, DOI: 10.1016/j.neuroimage.2012.05.007.Peer-Reviewed Original ResearchConceptsHigher taskLower taskFunctional magnetic resonance imaging studySpaced trialsSubsequent stimulus processingBrain regionsMagnetic resonance imaging studyDissociable influencesExecutive controlCognitive setResonance imaging studyNeural correlatesStimulus processingBrain systemsSwitch costsDevelopmental trajectoriesTask typeSet switchingSubcortical motor networksNew tasksInterstimulus intervalPassive decayTaskReaction timeCortical controlDiminished Frontostriatal Activity During Processing of Monetary Rewards and Losses in Pathological Gambling
Balodis IM, Kober H, Worhunsky PD, Stevens MC, Pearlson GD, Potenza MN. Diminished Frontostriatal Activity During Processing of Monetary Rewards and Losses in Pathological Gambling. Biological Psychiatry 2012, 71: 749-757. PMID: 22336565, PMCID: PMC3460522, DOI: 10.1016/j.biopsych.2012.01.006.Peer-Reviewed Original ResearchConceptsAlcohol dependencePathological gamblingVentral striatumMagnetic resonance imaging studyResonance imaging studyFunctional magnetic resonance imaging studyBrain activation changesMonetary incentive delay taskReward processingLoss processingPresent functional magnetic resonance imaging (fMRI) studyControl comparison groupIncentive delay taskVentral striatal activationPG groupMonetary rewardsVentromedial prefrontal cortexSimilar associationImaging studiesFrontostriatal activityLoss anticipationConsistent alterationsActivation changesPrefrontal cortexLevels of impulsivity
2010
Disruptions in Functional Network Connectivity During Alcohol Intoxicated Driving
Rzepecki‐Smith C, Meda SA, Calhoun VD, Stevens MC, Jafri MJ, Astur RS, Pearlson GD. Disruptions in Functional Network Connectivity During Alcohol Intoxicated Driving. Alcohol Clinical And Experimental Research 2010, 34: 479-487. PMID: 20028354, PMCID: PMC2858246, DOI: 10.1111/j.1530-0277.2009.01112.x.Peer-Reviewed Original ResearchConceptsBlood alcohol concentrationInfluence of alcoholFunctional network connectivityBasal gangliaAlcohol intoxicationBrain circuitsMajor public health problemMagnetic resonance imaging studyNormal motor behaviorPublic health problemResonance imaging studyFunctional magnetic resonance imaging studyIndividualized doseImpaired driving behaviorsAlcohol dosesActive doseMotor control functionsHealth problemsImaging studiesFunctional connectivityCerebellar circuitsMotor behaviorSocial drinkersInter-regional connectivityPlacebo