2023
Language Networks in Autism Spectrum Disorder: A systematic review of connectivity-based fMRI studies
Larson C, Thomas H, Crutcher J, Stevens M, Eigsti I. Language Networks in Autism Spectrum Disorder: A systematic review of connectivity-based fMRI studies. Review Journal Of Autism And Developmental Disorders 2023, 1-28. DOI: 10.1007/s40489-023-00382-6.Peer-Reviewed Original ResearchAutism spectrum disorderLanguage networkSpectrum disorderResting-state studiesFunctional neural connectivityNeurotypical peersASD symptomologyFMRI studyLanguage skillsFunctional connectivityCore featuresNeural connectivityNetwork regionsIdeal contextSocial functionLanguageConnectivityDisordersSymptomologyMixed patternPeersSkillsSystematic reviewPsychINFOIndividuals
2021
Response Inhibition Circuit Dysregulation in Substance Use Disorders Identified With Event-Related Potential-Derived Functional Connectivity
Steele V, Tootell A, Butler D, Fix S, Stevens M, Pearlson G, Bernat E. Response Inhibition Circuit Dysregulation in Substance Use Disorders Identified With Event-Related Potential-Derived Functional Connectivity. Biological Psychiatry 2021, 89: s350. DOI: 10.1016/j.biopsych.2021.02.873.Peer-Reviewed Original ResearchSubstance use disordersCircuit dysregulationUse disordersFunctional connectivityEvent-related potentials
2013
Is Aberrant Functional Connectivity A Psychosis Endophenotype? A Resting State Functional Magnetic Resonance Imaging Study
Khadka S, Meda SA, Stevens MC, Glahn DC, Calhoun VD, Sweeney JA, Tamminga CA, Keshavan MS, O’Neil K, Schretlen D, Pearlson GD. Is Aberrant Functional Connectivity A Psychosis Endophenotype? A Resting State Functional Magnetic Resonance Imaging Study. Biological Psychiatry 2013, 74: 458-466. PMID: 23746539, PMCID: PMC3752322, DOI: 10.1016/j.biopsych.2013.04.024.Peer-Reviewed Original ResearchConceptsPsychotic bipolar probandsNegative Syndrome Scale (PANSS) negative scoresState functional magnetic resonance imaging studyFunctional connectivityState functional magnetic resonanceBipolar disorder shareBrain connectivity abnormalitiesPosterior default mode networkSchizophrenia probandsMagnetic resonance imaging studyRespective first-degree relativesAberrant functional connectivityBipolar probandsFirst-degree relativesGroup differencesPsychosis endophenotypesNegative Syndrome ScaleResonance imaging studyFunctional magnetic resonance imaging studyDefault mode networkFunctional magnetic resonanceFunctional connectivity measuresFunctional Brain Networks Associated With Cognitive Control, Cocaine Dependence, and Treatment Outcome
Worhunsky PD, Stevens MC, Carroll KM, Rounsaville BJ, Calhoun VD, Pearlson GD, Potenza MN. Functional Brain Networks Associated With Cognitive Control, Cocaine Dependence, and Treatment Outcome. Psychology Of Addictive Behaviors 2013, 27: 477-488. PMID: 22775772, PMCID: PMC3743442, DOI: 10.1037/a0029092.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnalysis of VarianceBehavior, AddictiveCase-Control StudiesCerebral CortexCocaine-Related DisordersCognitive Behavioral TherapyData Interpretation, StatisticalExecutive FunctionFemaleFunctional NeuroimagingHumansLimbic SystemLinear ModelsMagnetic Resonance ImagingMaleMotivationNerve NetOxygenPrincipal Component AnalysisPsychomotor PerformanceStroop TestTreatment OutcomeConceptsCognitive controlCocaine dependencePoor cognitive controlCognitive control processesFunctional networksTreatment retentionDistinct functional networksIndependent component analysisFunctional brain networksConflict monitoringStroop taskTreatment outcome measuresMotivational processingCocaine-dependent patientsPrefrontal networkBrain networksSubcortical networksFunctional connectivityControl participantsFMRI dataRegional activationReduced involvementCortical networksTreatment developmentControl process
2012
Reduced Functional Connectivity of Prefrontal Regions and Amygdala Within Affect and Working Memory Networks in Pediatric Bipolar Disorder
Passarotti AM, Ellis J, Wegbreit E, Stevens MC, Pavuluri MN. Reduced Functional Connectivity of Prefrontal Regions and Amygdala Within Affect and Working Memory Networks in Pediatric Bipolar Disorder. Brain Connectivity 2012, 2: 320-334. PMID: 23035965, PMCID: PMC3621331, DOI: 10.1089/brain.2012.0089.Peer-Reviewed Original ResearchConceptsVentrolateral prefrontal cortexPediatric bipolar disorderRight ventrolateral prefrontal cortexWorking Memory NetworkFunctional connectivityMemory taskDorsolateral PFCBrain networksRight amygdalaMemory networkEmotion processing regionsEmotion regulation regionsDifferential functional connectivityFunctional magnetic resonanceBilateral temporal regionsConnected brain networksRegulation regionRegional functional connectivityNeutral facesEmotion processingCognitive processesEmotion evaluationPrefrontal regionsProcessing regionsBipolar disorderDefault mode network activity and white matter integrity in healthy middle-aged ApoE4 carriers
Patel KT, Stevens MC, Pearlson GD, Winkler AM, Hawkins KA, Skudlarski P, Bauer LO. Default mode network activity and white matter integrity in healthy middle-aged ApoE4 carriers. Brain Imaging And Behavior 2012, 7: 60-67. PMID: 23011382, DOI: 10.1007/s11682-012-9187-y.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnxietyApolipoprotein E4BrainData Interpretation, StatisticalDepressionDiffusion Tensor ImagingDNAFemaleGenotypeHeterozygoteHumansImage Processing, Computer-AssistedIntelligence TestsMagnetic Resonance ImagingMaleMiddle AgedNerve NetNeuropsychological TestsPrincipal Component AnalysisSmokingWechsler ScalesConceptsAPOE4 carriersMagnetic resonance imagingAlzheimer's diseaseFractional anisotropyFunctional MRI abnormalitiesUnderlying neuropathologic changesWhite matter fractional anisotropyWhite matter changesDefault mode network connectivityDefault mode network activityGenetic risk factorsMode network connectivityMiddle-aged adultsWhite matter integrityMRI abnormalitiesNeuropathologic changesRisk factorsApolipoprotein EMatter changesCognitive declineResonance imagingOlder ageFunctional connectivityGenetic riskDMN regionsMultiple resting state network functional connectivity abnormalities in mild traumatic brain injury
Stevens MC, Lovejoy D, Kim J, Oakes H, Kureshi I, Witt ST. Multiple resting state network functional connectivity abnormalities in mild traumatic brain injury. Brain Imaging And Behavior 2012, 6: 293-318. PMID: 22555821, DOI: 10.1007/s11682-012-9157-4.Peer-Reviewed Original ResearchConceptsTraumatic brain injuryMild traumatic brain injuryMild TBI patientsFunctional connectivity abnormalitiesTBI patientsBrain injuryConnectivity abnormalitiesFunctional connectivitySevere traumatic brain injuryWhite matter microstructural damagePostconcussive symptom severityWhole-brain functional connectivityFunctional connectivity deficitsCompensatory neural processesBrain networksBrain functional connectivityHealthy control participantsVoxelwise group comparisonsIntracerebral injuryNeurobiological sequelaeConnectivity deficitsAnterior cingulateBrain regionsSymptom severityAnatomical connectivity
2011
The Effects of Stimulant Medication on Working Memory Functional Connectivity in Attention-Deficit/Hyperactivity Disorder
Wong CG, Stevens MC. The Effects of Stimulant Medication on Working Memory Functional Connectivity in Attention-Deficit/Hyperactivity Disorder. Biological Psychiatry 2011, 71: 458-466. PMID: 22209640, PMCID: PMC4120250, DOI: 10.1016/j.biopsych.2011.11.011.Peer-Reviewed Original ResearchConceptsAttention-deficit/hyperactivity disorderFunctional magnetic resonance imagingFunctional connectivityFMRI taskHyperactivity disorderStimulant medicationNetwork engagementMemory fMRI taskFrontoparietal brain networksBrain regionsFrontoparietal brain regionsConnectivity changesMemory reaction timeVentrolateral prefrontal cortexAdditional brain regionsGroup independent component analysisMedication-related changesFunctional connectivity analysisRegional functional connectivityFunctional connectivity changesMemory performanceRepeated-measures t-testBrain activationIndependent component analysisRetrieval phaseAmygdala Functional Connectivity Predicts Pharmacotherapy Outcome in Pediatric Bipolar Disorder
Wegbreit E, Ellis JA, Nandam A, Fitzgerald JM, Passarotti AM, Pavuluri MN, Stevens MC. Amygdala Functional Connectivity Predicts Pharmacotherapy Outcome in Pediatric Bipolar Disorder. Brain Connectivity 2011, 1: 411-422. PMID: 22432455, PMCID: PMC3604767, DOI: 10.1089/brain.2011.0035.Peer-Reviewed Original ResearchPharmacotherapy impacts functional connectivity among affective circuits during response inhibition in pediatric mania
Pavuluri MN, Ellis JA, Wegbreit E, Passarotti AM, Stevens MC. Pharmacotherapy impacts functional connectivity among affective circuits during response inhibition in pediatric mania. Behavioural Brain Research 2011, 226: 493-503. PMID: 22004983, PMCID: PMC3253527, DOI: 10.1016/j.bbr.2011.10.003.Peer-Reviewed Original ResearchConceptsPediatric bipolar disorderAffective circuitsFunctional connectivityResponse inhibitionFMRI taskEmotional influencesAmygdala activityBehavioral inhibitionTask performanceTrait deficitAmygdala connectivityNeural operationsPediatric maniaNormative comparisonsSubgenual ACCFMRI trialAnti-epileptic medicationsMotor responseGreater engagementDifferential influenceStop signalBehavioral differencesCurrent studyDivalproex groupRisperidone group
2010
Brain Connectivity Is Not Only Lower but Different in Schizophrenia: A Combined Anatomical and Functional Approach
Skudlarski P, Jagannathan K, Anderson K, Stevens MC, Calhoun VD, Skudlarska BA, Pearlson G. Brain Connectivity Is Not Only Lower but Different in Schizophrenia: A Combined Anatomical and Functional Approach. Biological Psychiatry 2010, 68: 61-69. PMID: 20497901, PMCID: PMC2900394, DOI: 10.1016/j.biopsych.2010.03.035.Peer-Reviewed Original ResearchConceptsBrain connectivityFunctional connectivitySchizophrenia patientsAnatomical connectivityState functional magnetic resonance imagingFunctional connectivity alterationsHealthy control subjectsClinical symptom severityGroup differencesAnatomical connectivity mapsFunctional magnetic resonance imagingMagnetic resonance imagingPosterior cingulate cortexGlobal connectivity analysisClinical symptomsWhite matter anatomyControl subjectsConnectivity alterationsCingulate cortexPatientsResonance imagingBrain regionsSymptom severityDMN componentsTask-positive networkDisruptions in Functional Network Connectivity During Alcohol Intoxicated Driving
Rzepecki‐Smith C, Meda SA, Calhoun VD, Stevens MC, Jafri MJ, Astur RS, Pearlson GD. Disruptions in Functional Network Connectivity During Alcohol Intoxicated Driving. Alcohol Clinical And Experimental Research 2010, 34: 479-487. PMID: 20028354, PMCID: PMC2858246, DOI: 10.1111/j.1530-0277.2009.01112.x.Peer-Reviewed Original ResearchConceptsBlood alcohol concentrationInfluence of alcoholFunctional network connectivityBasal gangliaAlcohol intoxicationBrain circuitsMajor public health problemMagnetic resonance imaging studyNormal motor behaviorPublic health problemResonance imaging studyFunctional magnetic resonance imaging studyIndividualized doseImpaired driving behaviorsAlcohol dosesActive doseMotor control functionsHealth problemsImaging studiesFunctional connectivityCerebellar circuitsMotor behaviorSocial drinkersInter-regional connectivityPlacebo
2009
Evidence for Anomalous Network Connectivity during Working Memory Encoding in Schizophrenia: An ICA Based Analysis
Meda SA, Stevens MC, Folley BS, Calhoun VD, Pearlson GD. Evidence for Anomalous Network Connectivity during Working Memory Encoding in Schizophrenia: An ICA Based Analysis. PLOS ONE 2009, 4: e7911. PMID: 19936244, PMCID: PMC2775682, DOI: 10.1371/journal.pone.0007911.Peer-Reviewed Original ResearchConceptsTask accuracyFunctional connectivityPrefrontal cortexNetwork engagementLeft fronto-parietal networkRight dorsolateral prefrontal cortexMemory fMRI paradigmWorking Memory EncodingFronto-parietal networkVentrolateral prefrontal cortexNumerous neuroimaging studiesDorsolateral prefrontal cortexIndependent component analysisAbnormal regional brain activityDefault mode networkBrain network integrationDysfunctional brain regionsPrevious schizophrenia studiesRegional brain activityHippocampus/parahippocampusMemory encodingFMRI taskMemory cognitionMemory performanceFMRI paradigmAge-related cognitive gains are mediated by the effects of white matter development on brain network integration
Stevens MC, Skudlarski P, Pearlson GD, Calhoun VD. Age-related cognitive gains are mediated by the effects of white matter development on brain network integration. NeuroImage 2009, 48: 738-746. PMID: 19577651, PMCID: PMC2753497, DOI: 10.1016/j.neuroimage.2009.06.065.Peer-Reviewed Original ResearchConceptsCognitive controlBrain activityWhite matter developmentDevelopmental cognitive neuroscienceExecutive cognitive abilityBrain network integrationWhite matter coherenceCognitive neuroscienceCognitive abilitiesResponse inhibitionAdolescent developmentCognitive gainsBehavioral performanceSpecific white matter regionsFunctional integrationAge-related changesFirst multimodalBehavioral controlFunctional connectivityMaturational factorsBrain regionsLocal processingNetwork integrationFunctional circuitsNeuroscienceThe developmental cognitive neuroscience of functional connectivity
Stevens MC. The developmental cognitive neuroscience of functional connectivity. Brain And Cognition 2009, 70: 1-12. PMID: 19185406, DOI: 10.1016/j.bandc.2008.12.009.Peer-Reviewed Original ResearchConceptsDevelopmental cognitive neuroscienceCognitive neuroscienceFunctional connectivityFunctional connectivity analysisFunctional integrationCognitive controlBrain functional integrationCognitive maturationCognitive abilitiesConnectivity analysis methodCognitive developmentNeural substratesDevelopmental theoristsBehavioral controlConnectivity analysisNeuroscienceBrain regionsConceptual reviewCentral conceptBiological developmentRelevant conceptsCognitionRecent findingsNeural networkAdolescence
2007
A method for functional network connectivity among spatially independent resting-state components in schizophrenia
Jafri MJ, Pearlson GD, Stevens M, Calhoun VD. A method for functional network connectivity among spatially independent resting-state components in schizophrenia. NeuroImage 2007, 39: 1666-1681. PMID: 18082428, PMCID: PMC3164840, DOI: 10.1016/j.neuroimage.2007.11.001.Peer-Reviewed Original ResearchConceptsFunctional network connectivityFunctional connectivityTime courseICA time coursesHealthy controlsMagnetic resonance imaging dataHealthy individualsPatientsBrain disordersBrain regionsState fMRI dataCortical processingSchizophreniaFunctional magnetic resonance imaging (fMRI) dataSpatial independent component analysisSignificant differencesBrain networksComponent time coursesTemporal relationshipCoherent brain regionsBrainFMRI dataCourseImaging dataSeed voxels
2006
Functional neural circuits for mental timekeeping
Stevens MC, Kiehl KA, Pearlson G, Calhoun VD. Functional neural circuits for mental timekeeping. Human Brain Mapping 2006, 28: 394-408. PMID: 16944489, PMCID: PMC6871423, DOI: 10.1002/hbm.20285.Peer-Reviewed Original ResearchConceptsTiming taskFrontostriatal networkDifferent information processing stagesFunctional magnetic resonance imaging (fMRI) dataInformation processing stagesInformation processing modelPutamen/globus pallidusBilateral anterior insulaInterval timing taskSuperior temporal gyrusHemodynamic signal changesDistinct neural circuitsNeural circuitsPerformance of tasksIndependent component analysisAnterior cingulate gyrusSupplementary motor areaAnterior insulaFrontostriatal circuitsSupramarginal gyrusNeurobiological substratesTemporal gyrusMagnetic resonance imaging dataProcessing modelFunctional connectivity