2015
Contribution of maternal oxygenic state to the effects of chronic postnatal hypoxia on mouse body and brain development
Salmaso N, Dominguez M, Kravitz J, Komitova M, Vaccarino FM, Schwartz ML. Contribution of maternal oxygenic state to the effects of chronic postnatal hypoxia on mouse body and brain development. Neuroscience Letters 2015, 604: 12-17. PMID: 26222256, PMCID: PMC4568169, DOI: 10.1016/j.neulet.2015.07.033.Peer-Reviewed Original ResearchConceptsBrain weightEffects of hypoxiaDam exposureCortical volumeBody weightHypoxic conditionsBrain developmentChronic postnatal hypoxiaLow birth weightPup body weightSame hypoxic conditionsChronic hypoxia exposureEarly postnatal pupsBody weight conditionsHypoxic mothersNeurological sequelaePostnatal hypoxiaPremature infantsHypoxic pupsBirth weightChronic hypoxiaHypoxic chamberHypoxic exposureLive birthsMouse modelModulation of Sox10, HIF-1α, Survivin, and YAP by Minocycline in the Treatment of Neurodevelopmental Handicaps following Hypoxic Insult
Li Q, Tsuneki M, Krauthammer M, Couture R, Schwartz M, Madri JA. Modulation of Sox10, HIF-1α, Survivin, and YAP by Minocycline in the Treatment of Neurodevelopmental Handicaps following Hypoxic Insult. American Journal Of Pathology 2015, 185: 2364-2378. PMID: 26209807, PMCID: PMC5801488, DOI: 10.1016/j.ajpath.2015.05.016.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAnimalsApoptosisCell Cycle ProteinsDisease Models, AnimalHypoxiaHypoxia-Inducible Factor 1, alpha SubunitInhibitor of Apoptosis ProteinsMice, Inbred C57BLMinocyclineMultiple SclerosisPhosphoproteinsRepressor ProteinsSOXE Transcription FactorsSurvivinUp-RegulationYAP-Signaling ProteinsConceptsMinocycline treatmentNeurodevelopmental handicapHypoxic insultEffects of minocyclineUntoward side effectsAnimal model studiesPotential therapeutic targetSublethal hypoxic conditionsPremature infantsMultiple sclerosisCurrent therapiesTreatment trialsChronic hypoxiaSynaptic transmissionMurine modelMouse pupsMotor handicapNewborn populationSide effectsTherapeutic targetSublethal hypoxiaHIF-1αNerve transmissionMinocyclineCognitive function
2009
Strain Differences in Behavioral and Cellular Responses to Perinatal Hypoxia and Relationships to Neural Stem Cell Survival and Self-Renewal Modeling the Neurovascular Niche
Li Q, Liu J, Michaud M, Schwartz ML, Madri JA. Strain Differences in Behavioral and Cellular Responses to Perinatal Hypoxia and Relationships to Neural Stem Cell Survival and Self-Renewal Modeling the Neurovascular Niche. American Journal Of Pathology 2009, 175: 2133-2145. PMID: 19815710, PMCID: PMC2774076, DOI: 10.2353/ajpath.2009.090354.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBehavior, AnimalCell DifferentiationCell MovementCell SurvivalCells, CulturedChemokine CXCL12Endothelial CellsEnzyme ActivationFemaleHumansHypoxiaHypoxia-Inducible Factor 1, alpha SubunitHypoxia-Inducible Factor-Proline DioxygenasesInfantInfant, NewbornInfant, PrematureMaleMiceMice, Inbred C57BLMice, Inbred StrainsNeuronsNeuropsychological TestsPhosphatidylinositol 3-KinasesProcollagen-Proline DioxygenaseProto-Oncogene Proteins c-aktSignal TransductionStem CellsConceptsChronic hypoxiaC57 miceHIF-1alphaLow birth weight infant populationMatrix metalloproteinase-9 activityStromal-derived factor-1CD-1 miceMetalloproteinase-9 activityAdult C57 miceHypoxia-induced factorNeural stem cell survivalHigher apoptosis ratePerinatal hypoxiaRepair/recoveryClinical improvementNeurodevelopmental handicapPreventive therapyPremature infantsNeurogenic zonesNeurovascular nicheInfant populationC57BL/6 pupsProlyl hydroxylase domain 2Migratory responsivenessStem cell survival
1997
Chronic postnatal hypoxia increases the numbers of cortical neurons
Stewart W, Ment L, Schwartz M. Chronic postnatal hypoxia increases the numbers of cortical neurons. Brain Research 1997, 760: 17-21. PMID: 9237513, DOI: 10.1016/s0006-8993(97)00271-0.Peer-Reviewed Original ResearchConceptsCortical neuronsHypoxic ratsSublethal hypoxiaChronic postnatal hypoxiaChronic sublethal hypoxiaDays of hypoxiaCell deathPostnatal hypoxiaPremature infantsNeuronal densityBrain weightChronic hypoxiaCortical volumeClinical problemAnimal modelsCortical cell deathRatsThird dayHypoxiaLower bodyNeurodevelopmental disordersNeuronsConsiderable evidenceProlonged periodDeath