2016
Fibroblast Growth Factor 2 Modulates Hypothalamic Pituitary Axis Activity and Anxiety Behavior Through Glucocorticoid Receptors
Salmaso N, Stevens HE, McNeill J, ElSayed M, Ren Q, Maragnoli ME, Schwartz ML, Tomasi S, Sapolsky RM, Duman R, Vaccarino FM. Fibroblast Growth Factor 2 Modulates Hypothalamic Pituitary Axis Activity and Anxiety Behavior Through Glucocorticoid Receptors. Biological Psychiatry 2016, 80: 479-489. PMID: 27133954, PMCID: PMC8009045, DOI: 10.1016/j.biopsych.2016.02.026.Peer-Reviewed Original ResearchConceptsFibroblast growth factor-2Hippocampal glucocorticoid receptor expressionGlucocorticoid receptor expressionAdrenal axis activityKO miceAxis activityAnxiety behaviorReceptor expressionHypothalamic-pituitary axis activityReceptor KO miceFGF2 administrationWild-type miceGrowth factor 2Receptor subtypesTherapeutic effectNeuroendocrine studiesAdult miceGlucocorticoid receptorGR promoter regionsFGF2 levelsMeasures of anxietyMiceMotor behaviorFGF2 geneFactor 2
1999
Changes in cerebral cortex size are governed by fibroblast growth factor during embryogenesis
Vaccarino F, Schwartz M, Raballo R, Nilsen J, Rhee J, Zhou M, Doetschman T, Coffin J, Wyland J, Hung Y. Changes in cerebral cortex size are governed by fibroblast growth factor during embryogenesis. Nature Neuroscience 1999, 2: 246-253. PMID: 10195217, DOI: 10.1038/6350.Peer-Reviewed Original ResearchConceptsPseudostratified ventricular epitheliumFibroblast growth factor-2Number of gliaAdult cerebral cortexEnd of neurogenesisCerebral cortex sizeFibroblast growth factorGrowth factor 2Cerebral cortexCerebral ventricleSingle microinjectionCortical neuronsBrdU studiesCortical progenitorsVentricular epitheliumCortex sizeGrowth factorRat embryosFGF2 geneEarly neurogenesisFGF receptorsFactor 2GliaNeurogenesisCell cycle length