2017
Loss of TrkB Signaling in Parvalbumin-Expressing Basket Cells Results in Network Activity Disruption and Abnormal Behavior
Xenos D, Kamceva M, Tomasi S, Cardin JA, Schwartz ML, Vaccarino FM. Loss of TrkB Signaling in Parvalbumin-Expressing Basket Cells Results in Network Activity Disruption and Abnormal Behavior. Cerebral Cortex 2017, 28: 3399-3413. PMID: 28968898, PMCID: PMC6132287, DOI: 10.1093/cercor/bhx173.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBehavior, AnimalCerebral CortexElectrophysiological PhenomenaEvoked PotentialsInterneuronsLearning DisabilitiesMembrane GlycoproteinsMemory DisordersMice, Inbred C57BLMice, KnockoutMovement DisordersNeocortexNeuronsParvalbuminsProtein-Tyrosine KinasesPyramidal CellsSurvival AnalysisConceptsBrain-derived neurotrophic factorCKO miceBasket cellsParvalbumin cellsExcitatory neuronsParvalbumin-expressing (PV-expressing) basket cellsPutative excitatory neuronsParvalbumin-Expressing InterneuronsPrincipal excitatory neuronsInhibitory synaptic connectionsCell-intrinsic roleCortical interneuron developmentConditional knockout miceTrkB receptorsMotor deficitsTrkB SignalingPyramidal neuronsGABAergic systemNeurotrophic factorLocal field potentialsProfound hyperactivityCortical volumeNeuronal activityKnockout miceSensory cortex
2015
Contribution of maternal oxygenic state to the effects of chronic postnatal hypoxia on mouse body and brain development
Salmaso N, Dominguez M, Kravitz J, Komitova M, Vaccarino FM, Schwartz ML. Contribution of maternal oxygenic state to the effects of chronic postnatal hypoxia on mouse body and brain development. Neuroscience Letters 2015, 604: 12-17. PMID: 26222256, PMCID: PMC4568169, DOI: 10.1016/j.neulet.2015.07.033.Peer-Reviewed Original ResearchConceptsBrain weightEffects of hypoxiaDam exposureCortical volumeBody weightHypoxic conditionsBrain developmentChronic postnatal hypoxiaLow birth weightPup body weightSame hypoxic conditionsChronic hypoxia exposureEarly postnatal pupsBody weight conditionsHypoxic mothersNeurological sequelaePostnatal hypoxiaPremature infantsHypoxic pupsBirth weightChronic hypoxiaHypoxic chamberHypoxic exposureLive birthsMouse model
1998
Association of chronic sublethal hypoxia with ventriculomegaly in the developing rat brain
Ment L, Schwartz M, Makuch R, Stewart W. Association of chronic sublethal hypoxia with ventriculomegaly in the developing rat brain. Brain Research 1998, 111: 197-203. PMID: 9838111, DOI: 10.1016/s0165-3806(98)00139-4.Peer-Reviewed Original ResearchConceptsChronic sublethal hypoxiaSublethal hypoxiaBronchopulmonary dysplasiaAnimal modelsExperimental rat pupsSystemic blood pressureSubcortical white matterCorpus callosum sizePostnatal day 3Third groupNeurodevelopmental handicapPreterm infantsProlonged hypoxemiaBlood pressureCerebral ventriculomegalyExperimental time pointsChronic hypoxiaControl ratsCortical volumeRat pupsCallosum sizeNewborn ratsRat brainBody weightDay 3
1997
Chronic postnatal hypoxia increases the numbers of cortical neurons
Stewart W, Ment L, Schwartz M. Chronic postnatal hypoxia increases the numbers of cortical neurons. Brain Research 1997, 760: 17-21. PMID: 9237513, DOI: 10.1016/s0006-8993(97)00271-0.Peer-Reviewed Original ResearchConceptsCortical neuronsHypoxic ratsSublethal hypoxiaChronic postnatal hypoxiaChronic sublethal hypoxiaDays of hypoxiaCell deathPostnatal hypoxiaPremature infantsNeuronal densityBrain weightChronic hypoxiaCortical volumeClinical problemAnimal modelsCortical cell deathRatsThird dayHypoxiaLower bodyNeurodevelopmental disordersNeuronsConsiderable evidenceProlonged periodDeath