2008
Screening for Wilson disease in acute liver failure: A comparison of currently available diagnostic tests
Korman JD, Volenberg I, Balko J, Webster J, Schiodt FV, Squires RH, Fontana RJ, Lee WM, Schilsky ML, Groups P. Screening for Wilson disease in acute liver failure: A comparison of currently available diagnostic tests. Hepatology 2008, 48: 1167-1174. PMID: 18798336, PMCID: PMC4881751, DOI: 10.1002/hep.22446.Peer-Reviewed Original ResearchConceptsAcute liver failureDiagnosis of ALFSerum copper levelsFulminant Wilson's diseaseWilson's diseaseLiver failureDiagnostic sensitivityEmergency liver transplantationChronic liver diseaseAlkaline phosphataseAvailable diagnostic testsCopper levelsAvailable laboratory testsALF patientsTransplant listingLikelihood ratioLiver transplantationSerum aminotransferasesLiver diseaseALT ratioSerum ceruloplasminBilirubin ratioPatientsSerum CpRapid diagnosis
1995
Conditional immortalization of gunn rat hepatocytes: An ex vivo model for evaluating methods for bilirubin‐UDP‐glucuronosyltransferase gene transfer
Fox I, Chowdhury N, Gupta S, Kondapalli R, Schilsky M, Stockert R, Chowdhury J. Conditional immortalization of gunn rat hepatocytes: An ex vivo model for evaluating methods for bilirubin‐UDP‐glucuronosyltransferase gene transfer. Hepatology 1995, 21: 837-846. PMID: 7875682, DOI: 10.1002/hep.1840210334.Peer-Reviewed Original ResearchConceptsLarge T antigenSV40 large T antigenGene transfer vectorsT antigenGunn rat hepatocytesMutant SV40 large T antigenImmortalized cellsPrimary hepatocytesTransfer vectorsRecombinant Moloney murine leukemia virusMoloney murine leukemia virusMurine leukemia virusCorresponding mRNAExpression of albuminT promoterRat hepatocytesConditional immortalizationASGRGene transferCell growthViral vectorsBilirubin UGTDNA synthesisUDP-glucuronosyltransferase deficiencyHepatocyte clones