2022
An incentive circuit for memory dynamics in the mushroom body of Drosophila melanogaster
Gkanias E, McCurdy LY, Nitabach MN, Webb B. An incentive circuit for memory dynamics in the mushroom body of Drosophila melanogaster. ELife 2022, 11: e75611. PMID: 35363138, PMCID: PMC8975552, DOI: 10.7554/elife.75611.Peer-Reviewed Original ResearchConceptsFlexible behavioral controlConditioning paradigmNeural mechanismsNegative reinforcementMemory acquisitionBehavioral controlMemory dynamicsExploration/exploitationDrosophila melanogasterPlasticity rulesMushroom bodiesComputational modellingAcquisitionMemorySpecific neuronsStimuliDifferent rolesParadigmDrosophilaMelanogasterInsectsShort termFindingsNeuronsDopaminergic
2021
A neuronal ensemble encoding adaptive choice during sensory conflict in Drosophila
Sareen PF, McCurdy LY, Nitabach MN. A neuronal ensemble encoding adaptive choice during sensory conflict in Drosophila. Nature Communications 2021, 12: 4131. PMID: 34226544, PMCID: PMC8257655, DOI: 10.1038/s41467-021-24423-y.Peer-Reviewed Original ResearchFood odors decrease longevity via a brain–gut axis
Price K, Nitabach M. Food odors decrease longevity via a brain–gut axis. Nature Aging 2021, 1: 237-238. PMID: 37118407, DOI: 10.1038/s43587-021-00047-1.Peer-Reviewed Original ResearchC. elegans discriminates colors to guide foraging
Ghosh DD, Lee D, Jin X, Horvitz HR, Nitabach MN. C. elegans discriminates colors to guide foraging. Science 2021, 371: 1059-1063. PMID: 33674494, PMCID: PMC8554940, DOI: 10.1126/science.abd3010.Peer-Reviewed Original ResearchConceptsCellular stress response genesCellular stress response pathwaysStress response genesStress response pathwaysPhotoreceptor genesDiverse phylaC. elegansForaging decisionsResponse pathwaysResponse genesForagingOpsinGenesPhotosensitive cellsNatural environmentCaenorhabditisHarmful bacteriaElegansPhylaOrganismsBacteriaPathwayRoundwormsCellsToxinDopaminergic mechanism underlying reward-encoding of punishment omission during reversal learning in Drosophila
McCurdy LY, Sareen P, Davoudian PA, Nitabach MN. Dopaminergic mechanism underlying reward-encoding of punishment omission during reversal learning in Drosophila. Nature Communications 2021, 12: 1115. PMID: 33602917, PMCID: PMC7893153, DOI: 10.1038/s41467-021-21388-w.Peer-Reviewed Original ResearchConceptsDopaminergic neuronsCholinergic neuronsNeural circuit mechanismsCholinergic relayDopaminergic mechanismsSynaptic excitationSynaptic reconstructionSynaptic inputsVivo functional imagingCircuit mechanismsNeuronsAversive memoryFunctional imagingOdor responsesAversive outcomesReduced activationSuch activationCircuit motifsActivationOutcomesElectric shock punishmentSensory cuesUnexpected omissionShock punishmentBehavioral analysis
2018
Parvalbumin expression affects synaptic development and physiology at the Drosophila larval NMJ
He T, Nitabach MN, Lnenicka GA. Parvalbumin expression affects synaptic development and physiology at the Drosophila larval NMJ. Journal Of Neurogenetics 2018, 32: 209-220. PMID: 30175644, DOI: 10.1080/01677063.2018.1498496.Peer-Reviewed Original ResearchConceptsSingle action potentialAP trainsAction potentialsPresynaptic CaMuscle fiber 5Synaptic developmentMotor terminal growthPaired-pulse facilitationParvalbumin expressionFibers 5Transmitter releasePV expressionSynaptic boutonsIb terminalsSynaptic enhancementSynaptic facilitationOGB-1Electrophysiological recordingsParvalbuminRate of riseHomeostatic responseFluorescent CaLarval NMJsDrosophila neuronsResidual CaPeptide-Mediated Neurotransmission Takes Center Stage
Gonzalez-Suarez AD, Nitabach MN. Peptide-Mediated Neurotransmission Takes Center Stage. Trends In Neurosciences 2018, 41: 325-327. PMID: 29801523, PMCID: PMC5975383, DOI: 10.1016/j.tins.2018.03.013.Peer-Reviewed Original ResearchDaily oscillations in expression and responsiveness of Toll-like receptors in splenic immune cells
Silver AC, Buckley SM, Hughes ME, Hastings AK, Nitabach MN, Fikrig E. Daily oscillations in expression and responsiveness of Toll-like receptors in splenic immune cells. Heliyon 2018, 4: e00579. PMID: 29862343, PMCID: PMC5968137, DOI: 10.1016/j.heliyon.2018.e00579.Peer-Reviewed Original ResearchAdherent splenocytesToll-like receptor expressionMRNA levelsProtein levelsSplenic immune cellsToll-like receptorsDependent immune responsesZeitgeber time (ZT) 1Adherent cell populationDendritic cellsTLR3 ligandTLR ligandsCytokine expressionSplenocyte populationImmune cellsReceptor expressionImmune responseSplenic macrophagesB cellsRhythmic expressionCell populationsTLRSplenocytesDaily light-dark cycleCircadian rhythm
2017
Guidelines for Genome-Scale Analysis of Biological Rhythms
Hughes ME, Abruzzi KC, Allada R, Anafi R, Arpat AB, Asher G, Baldi P, de Bekker C, Bell-Pedersen D, Blau J, Brown S, Ceriani MF, Chen Z, Chiu JC, Cox J, Crowell AM, DeBruyne JP, Dijk DJ, DiTacchio L, Doyle FJ, Duffield GE, Dunlap JC, Eckel-Mahan K, Esser KA, FitzGerald GA, Forger DB, Francey LJ, Fu YH, Gachon F, Gatfield D, de Goede P, Golden SS, Green C, Harer J, Harmer S, Haspel J, Hastings MH, Herzel H, Herzog ED, Hoffmann C, Hong C, Hughey JJ, Hurley JM, de la Iglesia HO, Johnson C, Kay SA, Koike N, Kornacker K, Kramer A, Lamia K, Leise T, Lewis SA, Li J, Li X, Liu AC, Loros JJ, Martino TA, Menet JS, Merrow M, Millar AJ, Mockler T, Naef F, Nagoshi E, Nitabach MN, Olmedo M, Nusinow DA, Ptáček LJ, Rand D, Reddy AB, Robles MS, Roenneberg T, Rosbash M, Ruben MD, Rund SSC, Sancar A, Sassone-Corsi P, Sehgal A, Sherrill-Mix S, Skene DJ, Storch KF, Takahashi JS, Ueda HR, Wang H, Weitz C, Westermark PO, Wijnen H, Xu Y, Wu G, Yoo SH, Young M, Zhang EE, Zielinski T, Hogenesch JB. Guidelines for Genome-Scale Analysis of Biological Rhythms. Journal Of Biological Rhythms 2017, 32: 380-393. PMID: 29098954, PMCID: PMC5692188, DOI: 10.1177/0748730417728663.Peer-Reviewed Original ResearchConceptsGenome-scale analysisGenome-scale dataGenome-scale experimentsBiological rhythmsBiology approachBiology dataFuture discoveriesObvious consensusDifferent experimental designsProductive avenuesRNAProteinAbundanceComputational modelingPrimary literatureEnormous contributionClockDiscoveryRhythmMetabolitesGenetic and neuronal mechanisms governing the sex-specific interaction between sleep and sexual behaviors in Drosophila
Chen D, Sitaraman D, Chen N, Jin X, Han C, Chen J, Sun M, Baker BS, Nitabach MN, Pan Y. Genetic and neuronal mechanisms governing the sex-specific interaction between sleep and sexual behaviors in Drosophila. Nature Communications 2017, 8: 154. PMID: 28754889, PMCID: PMC5533705, DOI: 10.1038/s41467-017-00087-5.Peer-Reviewed Original ResearchA Peptidergic Circuit Links the Circadian Clock to Locomotor Activity
King AN, Barber AF, Smith AE, Dreyer AP, Sitaraman D, Nitabach MN, Cavanaugh DJ, Sehgal A. A Peptidergic Circuit Links the Circadian Clock to Locomotor Activity. Current Biology 2017, 27: 1915-1927.e5. PMID: 28669757, PMCID: PMC5698909, DOI: 10.1016/j.cub.2017.05.089.Peer-Reviewed Original ResearchConceptsLocomotor activitySubesophageal zonePeptidergic circuitsPars intercerebralisCorticotropin-releasing factorVentral nerve cordSite of actionReceptor 1Motor outputCircadian locomotor activityNerve cordNeuronsRelevant receptorsDrosophila brainHr rhythmsCircadian driveRhythmFeeding rhythmDiuretic hormone 44Minimal effectActivity rhythmsBehavioral rhythmsCircadian locomotionCircadian controlCordMultisensory integration in C. elegans
Ghosh DD, Nitabach MN, Zhang Y, Harris G. Multisensory integration in C. elegans. Current Opinion In Neurobiology 2017, 43: 110-118. PMID: 28273525, PMCID: PMC5501174, DOI: 10.1016/j.conb.2017.01.005.Peer-Reviewed Original ResearchMembrane Currents, Gene Expression, and Circadian Clocks
Allen CN, Nitabach MN, Colwell CS. Membrane Currents, Gene Expression, and Circadian Clocks. Cold Spring Harbor Perspectives In Biology 2017, 9: a027714. PMID: 28246182, PMCID: PMC5411696, DOI: 10.1101/cshperspect.a027714.Peer-Reviewed Original ResearchConceptsCircadian clockGene ClockMembrane electrical activityCyclic adenosine monophosphateCircadian clock neuronsCircadian outputClock neuronsGenetic clockGene expressionCircadian oscillatorIntracellular CaAdenosine monophosphateFeedback loopPathwayClockHuman healthAction potential firing patternsMammalianActivityAction potential firingNightly reductionsMultiple typesExpressionMembrane currentsCircadian pattern
2016
Neural Architecture of Hunger-Dependent Multisensory Decision Making in C. elegans
Ghosh DD, Sanders T, Hong S, McCurdy LY, Chase DL, Cohen N, Koelle MR, Nitabach MN. Neural Architecture of Hunger-Dependent Multisensory Decision Making in C. elegans. Neuron 2016, 92: 1049-1062. PMID: 27866800, PMCID: PMC5147516, DOI: 10.1016/j.neuron.2016.10.030.Peer-Reviewed Original ResearchDrosophila DH31 Neuropeptide and PDF Receptor Regulate Night-Onset Temperature Preference
Goda T, Tang X, Umezaki Y, Chu ML, Kunst M, Nitabach MNN, Hamada FN. Drosophila DH31 Neuropeptide and PDF Receptor Regulate Night-Onset Temperature Preference. Journal Of Neuroscience 2016, 36: 11739-11754. PMID: 27852781, PMCID: PMC5125228, DOI: 10.1523/jneurosci.0964-16.2016.Peer-Reviewed Original ResearchGoggatomy: A Method for Opening Small Cuticular Compartments in Arthropods for Physiological Experiments
Kay AR, Raccuglia D, Scholte J, Sivan-Loukianova E, Barwacz CA, Armstrong SR, Guymon CA, Nitabach MN, Eberl DF. Goggatomy: A Method for Opening Small Cuticular Compartments in Arthropods for Physiological Experiments. Frontiers In Physiology 2016, 7: 398. PMID: 27695420, PMCID: PMC5025716, DOI: 10.3389/fphys.2016.00398.Peer-Reviewed Original ResearchPresynaptic GABA Receptors Mediate Temporal Contrast Enhancement in Drosophila Olfactory Sensory Neurons and Modulate Odor-Driven Behavioral Kinetics
Raccuglia D, McCurdy LY, Demir M, Gorur-Shandilya S, Kunst M, Emonet T, Nitabach MN. Presynaptic GABA Receptors Mediate Temporal Contrast Enhancement in Drosophila Olfactory Sensory Neurons and Modulate Odor-Driven Behavioral Kinetics. ENeuro 2016, 3: eneuro.0080-16.2016. PMID: 27588305, PMCID: PMC4994068, DOI: 10.1523/eneuro.0080-16.2016.Peer-Reviewed Original ResearchConceptsOlfactory sensory neuronsPeripheral responsesGABA receptorsSensory neuronsContrast enhancementOSN axon terminalsInhibitory GABA receptorsPresynaptic GABAAxon terminalsDrosophila olfactory sensory neuronsPresynaptic terminalsNervous systemAuditory stimuliTemporal edgeOlfactory systemTime courseNeuronsInnate behavioral responsesReceptorsOptical electrophysiologyTemporal contrast enhancementBehavioral responsesLateral inhibitionResponseGABA
2015
Corrigendum: Control of Sleep by Dopaminergic Inputs to the Drosophila Mushroom Body
Sitaraman D, Aso Y, Rubin GM, Nitabach MN. Corrigendum: Control of Sleep by Dopaminergic Inputs to the Drosophila Mushroom Body. Frontiers In Neural Circuits 2015, 9: 84. PMID: 26733821, PMCID: PMC4686686, DOI: 10.3389/fncir.2015.00084.Peer-Reviewed Original ResearchControl of Sleep by Dopaminergic Inputs to the Drosophila Mushroom Body
Sitaraman D, Aso Y, Rubin GM, Nitabach MN. Control of Sleep by Dopaminergic Inputs to the Drosophila Mushroom Body. Frontiers In Neural Circuits 2015, 9: 73. PMID: 26617493, PMCID: PMC4637407, DOI: 10.3389/fncir.2015.00073.Peer-Reviewed Original ResearchPropagation of Homeostatic Sleep Signals by Segregated Synaptic Microcircuits of the Drosophila Mushroom Body
Sitaraman D, Aso Y, Jin X, Chen N, Felix M, Rubin GM, Nitabach MN. Propagation of Homeostatic Sleep Signals by Segregated Synaptic Microcircuits of the Drosophila Mushroom Body. Current Biology 2015, 25: 2915-2927. PMID: 26455303, PMCID: PMC4654684, DOI: 10.1016/j.cub.2015.09.017.Peer-Reviewed Original ResearchConceptsSynaptic microcircuitsDrosophila mushroom bodyKenyon cellsMushroom bodiesMB neuronsControl of sleepHomeostatic rebound sleepHomeostatic sleep regulationIncreases sleepRebound sleepSleep regulationMBONsSleep deprivationNeuron classesSleepSleep informationMemory centerSpecific functional connectionsFunctional connectionsNeuronsPhysiological approachDifferent populationsMicrocircuits