2023
Prostate cancer risk stratification using magnetic resonance imaging–ultrasound fusion vs systematic prostate biopsy
Khajir G, Press B, Lokeshwar S, Ghabili K, Rahman S, Gardezi M, Washington S, Cooperberg M, Sprenkle P, Leapman M. Prostate cancer risk stratification using magnetic resonance imaging–ultrasound fusion vs systematic prostate biopsy. JNCI Cancer Spectrum 2023, 7: pkad099. PMID: 38085220, PMCID: PMC10733209, DOI: 10.1093/jncics/pkad099.Peer-Reviewed Original ResearchConceptsMagnetic resonance imaging-ultrasound fusionMRF-TBLow-risk diseaseSystematic biopsyLower riskRisk groupingProstate biopsyActive surveillanceHigh riskProstate cancer risk stratificationIntermediate-risk criteriaIntermediate-risk diseaseSystematic prostate biopsyCancer risk stratificationPrimary study objectiveNCCN guidelinesImage-guided approachLocalized cancerRisk stratificationBenign findingsProstate cancerClinical riskDiagnostic yieldRetrospective analysisBiopsyEnvironmental Impact of Prostate Magnetic Resonance Imaging and Transrectal Ultrasound Guided Prostate Biopsy
Leapman M, Thiel C, Gordon I, Nolte A, Perecman A, Loeb S, Overcash M, Sherman J. Environmental Impact of Prostate Magnetic Resonance Imaging and Transrectal Ultrasound Guided Prostate Biopsy. European Urology 2023, 83: 463-471. PMID: 36635108, DOI: 10.1016/j.eururo.2022.12.008.Peer-Reviewed Original ResearchMeSH KeywordsBiopsyCarbon DioxideGasolineGreenhouse GasesHumansImage-Guided BiopsyMagnetic Resonance ImagingMaleProstateProstatic NeoplasmsUltrasonography, InterventionalConceptsProstate magnetic resonance imagingMagnetic resonance imagingSystematic biopsyProstate biopsyProstate biopsy procedureResonance imagingBiopsy coresTransrectal Ultrasound Guided Prostate BiopsyBiopsy procedureMultiparametric magnetic resonance imagingUnnecessary prostate biopsiesBiparametric magnetic resonance imagingOutpatient urology clinicNumber of biopsiesGuided Prostate BiopsyAcademic medical centerHealth care facilitiesEvidence-based approachUrology clinicClinical managementMedical CenterTriage strategiesClinical careTransrectal ultrasoundBiopsy
2018
Association Between Prostate Magnetic Resonance Imaging and Observation for Low-risk Prostate Cancer
Leapman MS, Wang R, Park HS, Yu JB, Weinreb JC, Gross CP, Ma X. Association Between Prostate Magnetic Resonance Imaging and Observation for Low-risk Prostate Cancer. Urology 2018, 124: 98-106. PMID: 30107188, DOI: 10.1016/j.urology.2018.07.041.Peer-Reviewed Original ResearchMeSH KeywordsAgedHumansMagnetic Resonance ImagingMaleProstatic NeoplasmsRisk AssessmentWatchful WaitingConceptsLow-risk prostate cancerProstate magnetic resonance imagingMagnetic resonance imagingProstate cancerDefinitive treatmentPCa diagnosisEnd Results-Medicare databaseResonance imagingMultivariable logistic regression analysisPropensity scoreDiagnosis of PCaUse of MRIConditional logistic regression modelsLogistic regression analysisLogistic regression modelsInitial managementMultivariable analysisGreater oddsPatientsSocioeconomic statusDiagnosisHigher likelihoodRegression analysisDemographic factorsCancer
2017
Association between a 17-gene genomic prostate score and multi-parametric prostate MRI in men with low and intermediate risk prostate cancer (PCa)
Leapman MS, Westphalen AC, Ameli N, Lawrence HJ, Febbo PG, Cooperberg MR, Carroll PR. Association between a 17-gene genomic prostate score and multi-parametric prostate MRI in men with low and intermediate risk prostate cancer (PCa). PLOS ONE 2017, 12: e0185535. PMID: 29016610, PMCID: PMC5634556, DOI: 10.1371/journal.pone.0185535.Peer-Reviewed Original ResearchMeSH KeywordsAgedBiopsyGene ExpressionHumansMagnetic Resonance ImagingMaleMiddle AgedNeoplasm GradingNeoplasm ProteinsProstateProstatic NeoplasmsRiskConceptsGenomic Prostate ScoreIntermediate-risk prostate cancerRisk prostate cancerProstate cancerMean apparent diffusion coefficientApparent diffusion coefficientPattern 3Prostate MRISuspicion of malignancyGleason pattern 3Multi-parametric prostate MRIMultiple comparison testFive-tier scaleDunn's multiple comparison testMpMRI findingsMRI findingsMRI groupMRI scoresActive surveillanceDominant lesionStromal responseMRI categoryAndrogen signalingKruskal-Wallis testSignificant association