COL10A1 expression distinguishes a subset of cancer-associated fibroblasts present in the stroma of high-risk basal cell carcinoma
Esposito M, Yerly L, Shukla P, Hermes V, Sella F, Balazs Z, Lattmann E, Tastanova A, Turko P, Lang R, Kolm I, Staeger R, Kuonen F, Krauthammer M, Hafner J, Levesque M, Restivo G. COL10A1 expression distinguishes a subset of cancer-associated fibroblasts present in the stroma of high-risk basal cell carcinoma. British Journal Of Dermatology 2024, 191: 775-790. PMID: 38916477, DOI: 10.1093/bjd/ljae258.Peer-Reviewed Original ResearchBasal cell carcinoma subtypesBasal cell carcinomaCancer-associated fibroblastsHigh-risk basal cell carcinomasInvasive BCCCancer-associated fibroblast populationsLaser capture microdissectionCell carcinomaHigh-risk BCC subtypesSubtypes of basal cell carcinomaHigh risk of recurrenceBasal cell carcinoma developmentBasal cell carcinoma progressionHigh-risk subtypesBasal cell carcinoma samplesGene expression signaturesTailored treatment optionsBasosquamous subtypesHealthy skin samplesRNA sequencingStromal featuresTumor microenvironmentMorphological subtypesTreatment optionsPrognostic biomarker