Cellular Expression and Functional Roles of All 26 Neurotransmitter GPCRs in the C. elegans Egg-Laying Circuit
Fernandez RW, Wei K, Wang EY, Mikalauskaite D, Olson A, Pepper J, Christie N, Kim S, Weissenborn S, Sarov M, Koelle MR. Cellular Expression and Functional Roles of All 26 Neurotransmitter GPCRs in the C. elegans Egg-Laying Circuit. Journal Of Neuroscience 2020, 40: 7475-7488. PMID: 32847964, PMCID: PMC7511189, DOI: 10.1523/jneurosci.1357-20.2020.Peer-Reviewed Original ResearchConceptsEgg-laying circuitNeurotransmitter GPCREgg-laying defectsModel organismsNeural circuitsExtrasynaptic signalsStandard laboratory conditionsSuch signalingGPCR expressionCell typesFunctional roleGPCRsNeurotransmitter signalsCellular expressionActivity of neuronsModel systemEpithelial cellsReceptor functionOrganismsNeurotransmitter receptorsLaboratory conditionsDistinct receptorsReceptor knockoutParkinson's diseaseCells