2001
Differential Activation of the STAT Pathway by Angiotensin II via Angiotensin Type 1 and Type 2 Receptors in Cultured Human Fetal Mesangial Cells
Seebach F, Welte T, Fu X, Block L, Kashgarian M. Differential Activation of the STAT Pathway by Angiotensin II via Angiotensin Type 1 and Type 2 Receptors in Cultured Human Fetal Mesangial Cells. Experimental And Molecular Pathology 2001, 70: 265-273. PMID: 11418005, DOI: 10.1006/exmp.2001.2361.Peer-Reviewed Original ResearchMeSH KeywordsAngiotensin IICells, CulturedDNA-Binding ProteinsFetusGlomerular MesangiumHumansKineticsMilk ProteinsPhosphorylationProtein TransportReceptor, Angiotensin, Type 1Receptor, Angiotensin, Type 2Receptors, AngiotensinSTAT1 Transcription FactorSTAT2 Transcription FactorSTAT5 Transcription FactorTrans-ActivatorsConceptsDNA-binding activityHuman mesangial cellsStat5 DNA-binding activityNuclear translocationSTAT-DNA bindingAngiotensin IISTAT5 tyrosine phosphorylationElectromobility shift assaysReceptor subtype-specific mannerMesangial cellsReceptor-specific signalingSTAT proteinsTyrosine phosphorylationShift assaysTranscription pathwayHuman fetal mesangial cellsSignal transducerSubtype-specific mannerCellular responsesSTAT pathwayAngiotensin receptor type 2Renal mesangial cellsAngiotensin II resultsVasoactive peptide angiotensin IIPossible regulator
1993
Transport defects of rabbit medullary thick ascending limb cells in obstructive nephropathy.
Hwang S, Haas M, Harris H, Silva P, Yalla S, Sullivan M, Otuechere G, Kashgarian M, Zeidel M. Transport defects of rabbit medullary thick ascending limb cells in obstructive nephropathy. Journal Of Clinical Investigation 1993, 91: 21-28. PMID: 8380811, PMCID: PMC329990, DOI: 10.1172/jci116173.Peer-Reviewed Original ResearchConceptsMedullary thick ascending limbNa-K-ATPase activityNa-K-ATPaseBasolateral Na-K-ATPaseObstructed kidneysObstructive nephropathyUreteral obstructionLuminal NaRelease of obstructionThick ascending limbMajor sodium transportersUntreated kidneysTransport defectSpecific monoclonal antibodiesSodium transport defectsControl animalsAscending limbOuter medullaKidneyApical NaMarked reductionMonoclonal antibodiesMTAL cellsInhibitory effectObstruction
1989
Aldosterone induction of electrogenic sodium transport in the apical membrane vesicles of rat distal colon*
Rajendran V, Kashgarian M, Binder H. Aldosterone induction of electrogenic sodium transport in the apical membrane vesicles of rat distal colon*. Journal Of Biological Chemistry 1989, 264: 18638-18644. PMID: 2553716, DOI: 10.1016/s0021-9258(18)51514-3.Peer-Reviewed Original ResearchConceptsDistal colonRat distal colonNa-H exchangeElectrogenic sodium transportSodium transportExperimental ratsMicroM amilorideAmiloride-sensitive electrogenic sodium transportNormal rat distal colonEffects of aldosteroneElectroneutral sodium absorptionSodium concentrationApical membrane vesiclesAnalogues of amilorideVoltage-clamp conditionsDietary sodiumNormal ratsAldosterone inductionSodium absorptionColonComparable inhibitionRatsAmilorideAldosteronePotent inhibitorProtection of the kidney against ischemic injury by inhibition of 5'-nucleotidase
Van Waarde A, Stromski M, Thulin G, Gaudio K, Kashgarian M, Shulman R, Siegel N. Protection of the kidney against ischemic injury by inhibition of 5'-nucleotidase. American Journal Of Physiology 1989, 256: f298-f305. PMID: 2537026, DOI: 10.1152/ajprenal.1989.256.2.f298.Peer-Reviewed Original ResearchConceptsRenal ischemic insultResidual nucleotide poolMin of ischemiaRenal ATP contentFunctional recoveryIschemic injuryIschemic insultKidney functionRenal ischemiaIntramuscular injectionUntreated ratsRapid initial recoveryATP restorationRat kidneyRenal ATPIschemiaInitial recoveryKidneyRatsATP contentInsultFunctional consequencesNucleotide poolMagnetic resonanceAMPCP
1986
Ubiquinone-8 Stimulates Phagocytosis in Macrophages by Modulation of the Kinetics of the Fc Receptor
Block L, Georgopoulos A, Biemesderfer D, Herzog C, Kashgarian M, Sitaramam V. Ubiquinone-8 Stimulates Phagocytosis in Macrophages by Modulation of the Kinetics of the Fc Receptor. The Journal Of Infectious Diseases 1986, 153: 209-215. PMID: 3944478, DOI: 10.1093/infdis/153.2.209.Peer-Reviewed Original Research
1983
Role of angiotensin II-induced renal functional changes in mesangial deposition of exogenous ferritin in rats.
Stein H, Feddergreen W, Kashgarian M, Sterzel R. Role of angiotensin II-induced renal functional changes in mesangial deposition of exogenous ferritin in rats. Laboratory Investigation 1983, 49: 270-80. PMID: 6350702.Peer-Reviewed Original ResearchConceptsBlood pressureFiltration fractionMesangial localizationAngiotensin IIFunctional changesAcute angiotensin IIAminohippuric acid clearanceRenal functional changesSystolic blood pressureExcretion of albuminSingle intravenous doseGlomerular capillary permeabilityGroups of ratsInjection of ferritinPressor doseAcid clearanceIntravenous doseMesangial depositionMesangial accumulationFerritin concentrationInulin clearanceTreatment periodRenal tissueSerial measurementsFerritin deposition