1993
Expression of parathyroid hormone-related protein in the rat glomerulus and tubule during recovery from renal ischemia.
Soifer N, Van Why S, Ganz M, Kashgarian M, Siegel N, Stewart A. Expression of parathyroid hormone-related protein in the rat glomerulus and tubule during recovery from renal ischemia. Journal Of Clinical Investigation 1993, 92: 2850-2857. PMID: 8254039, PMCID: PMC288486, DOI: 10.1172/jci116905.Peer-Reviewed Original ResearchMeSH KeywordsActinsAmino Acid IsomerasesAnimalsBlotting, NorthernCarrier ProteinsGene ExpressionImmunohistochemistryIschemiaKidneyKidney GlomerulusKidney TubulesMaleParathyroid Hormone-Related ProteinPeptidylprolyl IsomeraseProtein BiosynthesisProteinsRatsRats, Sprague-DawleyReceptors, Parathyroid HormoneReference ValuesRenal ArteryReperfusionRNA, MessengerConceptsHormone-related proteinMesangial cellsTubular cellsAcute renal ischemic injuryBilateral renal artery occlusionMale Sprague-Dawley ratsParathyroid hormone-related proteinAutocrine/paracrine fashionPTHrP mRNA levelsRenal artery occlusionRenal ischemic injuryMRNA levelsSprague-Dawley ratsDistal tubular cellsSham-operated animalsCyclophilin mRNA levelsProximal tubular cellsLocalization of PTHrPCultured mesangial cellsLocal growth factorsAdult rat kidneyArtery occlusionGlomerular epithelial cellsRenal injuryIschemic injury
1992
THE EFFECT OF CYCLOSPORINE ADMINISTRATION ON THE CELLULAR DISTRIBUTION AND CONTENT OF CYCLOPHILIN 1
McDONALD M, ARDITO T, MARKS W, KASHGARIAN M, LORBER M. THE EFFECT OF CYCLOSPORINE ADMINISTRATION ON THE CELLULAR DISTRIBUTION AND CONTENT OF CYCLOPHILIN 1. Transplantation 1992, 53: 460-466. PMID: 1472259, DOI: 10.1097/00007890-199202010-00037.Peer-Reviewed Original ResearchConceptsCyclosporine metabolitesDays of CsAUntreated Wistar ratsPrevious immunohistochemical analysisCyclosporine administrationCsA therapyLymph nodesWistar ratsImmunohistochemical analysisCYP contentBiologic effectsMitochondria-endoplasmic reticulumQuantitative immunofluorescenceNuclear stainingGeneralized increaseCYP interactionsCsAEnzyme peptidyl-prolyl cis-trans isomeraseCellular distributionIleumKidneyUntreated controlsLiverBiological effectsConfocal microscopy