1993
Spatial organization of the extracellular matrix modulates the expression of PDGF-receptor subunits in mesangial cells
Marx M, Daniel T, Kashgarian M, Madri J. Spatial organization of the extracellular matrix modulates the expression of PDGF-receptor subunits in mesangial cells. Kidney International 1993, 43: 1027-1041. PMID: 8510381, DOI: 10.1038/ki.1993.145.Peer-Reviewed Original ResearchConceptsPDGF receptor subunitsMesangial cell phenotypeCell surfaceExtracellular matrixCell phenotypeExtracellular matrix environmentSpatial organizationPDGF responsivenessPDGF receptor alphaTwo-dimensional cultureMulticellular structuresThree-dimensional cultureMetabolic labelingDifferential expressionQuiescent cellsRat mesangial cell growthCell growthPDGF isoforms AASubunitsMatrix environmentCell proliferationPDGF isoformsReceptor subunitsUltrastructural analysisSurface expression
1986
Mesangial cell hillocks. Nodular foci of exaggerated growth of cells and matrix in prolonged culture.
Sterzel R, Lovett D, Foellmer H, Perfetto M, Biemesderfer D, Kashgarian M. Mesangial cell hillocks. Nodular foci of exaggerated growth of cells and matrix in prolonged culture. American Journal Of Pathology 1986, 125: 130-40. PMID: 3535527, PMCID: PMC1888434.Peer-Reviewed Original ResearchConceptsMesangial cellsNecrotic cell debrisCollagen type IMesangial matrix productionCultured mesangial cellsGlomerular mesangial cellsIsolated rat glomeruliType ISpecific rabbit polyclonal antibodiesNodular fociFetal calf serumDiseased glomeruliMC proliferationRabbit polyclonal antibodyStellate cellsNormal glomeruliMatrix proteinsInterstitial collagen types ICell debrisImmunocytochemical studyNodular accumulationMetabolic stimuliIntracellular fibrilsRat glomeruliGlomeruli