Differential Activation of the STAT Pathway by Angiotensin II via Angiotensin Type 1 and Type 2 Receptors in Cultured Human Fetal Mesangial Cells
Seebach F, Welte T, Fu X, Block L, Kashgarian M. Differential Activation of the STAT Pathway by Angiotensin II via Angiotensin Type 1 and Type 2 Receptors in Cultured Human Fetal Mesangial Cells. Experimental And Molecular Pathology 2001, 70: 265-273. PMID: 11418005, DOI: 10.1006/exmp.2001.2361.Peer-Reviewed Original ResearchMeSH KeywordsAngiotensin IICells, CulturedDNA-Binding ProteinsFetusGlomerular MesangiumHumansKineticsMilk ProteinsPhosphorylationProtein TransportReceptor, Angiotensin, Type 1Receptor, Angiotensin, Type 2Receptors, AngiotensinSTAT1 Transcription FactorSTAT2 Transcription FactorSTAT5 Transcription FactorTrans-ActivatorsConceptsDNA-binding activityHuman mesangial cellsStat5 DNA-binding activityNuclear translocationSTAT-DNA bindingAngiotensin IISTAT5 tyrosine phosphorylationElectromobility shift assaysReceptor subtype-specific mannerMesangial cellsReceptor-specific signalingSTAT proteinsTyrosine phosphorylationShift assaysTranscription pathwayHuman fetal mesangial cellsSignal transducerSubtype-specific mannerCellular responsesSTAT pathwayAngiotensin receptor type 2Renal mesangial cellsAngiotensin II resultsVasoactive peptide angiotensin IIPossible regulatorMolecular mechanisms of TGF‐β antagonism by interferon γ and cyclosporine A in lung fibroblasts
EICKELBERG O, PANSKY A, KOEHLER E, BIHL M, TAMM M, HILDEBRAND P, PERRUCHOUD A, KASHGARIAN M, ROTH M. Molecular mechanisms of TGF‐β antagonism by interferon γ and cyclosporine A in lung fibroblasts. The FASEB Journal 2001, 15: 797-806. PMID: 11259398, DOI: 10.1096/fj.00-0233com.Peer-Reviewed Original ResearchMeSH KeywordsCells, CulturedCollagenCyclosporineDNA-Binding ProteinsExtracellular MatrixFibroblastsGenes, ReporterHumansInterferon-gammaLungModels, BiologicalOligonucleotides, AntisenseProto-Oncogene Proteins c-junPulmonary FibrosisSignal TransductionSTAT1 Transcription FactorTrans-ActivatorsTranscription Factor AP-1Transforming Growth Factor betaConceptsCollagen depositionLung fibroblastsIFN-gammaExcess extracellular matrix depositionGrowth factor-beta activityPrimary human lung fibroblastsFibrotic lung diseaseHuman lung fibroblastsTGF-beta antagonismAP-1IFN-gamma treatmentExtracellular matrix depositionLung fibrosisFatal conditionLung diseaseMolecular mechanismsPathological featuresInterferon γTranscription factor AP-1Future therapiesPharmacological agentsJunD homodimersFactor AP-1Novel targetDirect inhibition