1997
A Tyrosine-Based Signal Targets H/K-ATPase to a Regulated Compartment and Is Required for the Cessation of Gastric Acid Secretion
Courtois-Coutry N, Roush D, Rajendran V, McCarthy J, Geibel J, Kashgarian M, Caplan M. A Tyrosine-Based Signal Targets H/K-ATPase to a Regulated Compartment and Is Required for the Cessation of Gastric Acid Secretion. Cell 1997, 90: 501-510. PMID: 9267030, DOI: 10.1016/s0092-8674(00)80510-3.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCalciumCOS CellsCytomegalovirusDNA PrimersEndocytosisGastric AcidGastric MucosaH(+)-K(+)-Exchanging ATPaseMacromolecular SubstancesMiceMice, TransgenicMicroscopy, ImmunoelectronMutagenesis, Site-DirectedParietal Cells, GastricPolymerase Chain ReactionPromoter Regions, GeneticRecombinant ProteinsSignal TransductionTransfectionTyrosineConceptsK-ATPase beta subunitTyrosine-based signalsK-ATPaseTyrosine-based endocytosis signalTyrosine residuesBeta subunitIntracellular storage compartmentEndocytosis signalCytoplasmic tailMutant betaRegulated compartmentsSecrete acidResidue sequenceStorage compartmentCell surfaceCell plasmalemmaSubunitsTransgenic miceParietal cellsGastric glandsCompartmentsSecretionAcid secretionReinternalizationPlasmalemma
1994
Expression and molecular regulation of Na(+)-K(+)-ATPase after renal ischemia
Van Why S, Mann A, Ardito T, Siegel N, Kashgarian M. Expression and molecular regulation of Na(+)-K(+)-ATPase after renal ischemia. American Journal Of Physiology 1994, 267: f75-f85. PMID: 8048568, DOI: 10.1152/ajprenal.1994.267.1.f75.Peer-Reviewed Original Research
1993
Spatial organization of the extracellular matrix modulates the expression of PDGF-receptor subunits in mesangial cells
Marx M, Daniel T, Kashgarian M, Madri J. Spatial organization of the extracellular matrix modulates the expression of PDGF-receptor subunits in mesangial cells. Kidney International 1993, 43: 1027-1041. PMID: 8510381, DOI: 10.1038/ki.1993.145.Peer-Reviewed Original ResearchConceptsPDGF receptor subunitsMesangial cell phenotypeCell surfaceExtracellular matrixCell phenotypeExtracellular matrix environmentSpatial organizationPDGF responsivenessPDGF receptor alphaTwo-dimensional cultureMulticellular structuresThree-dimensional cultureMetabolic labelingDifferential expressionQuiescent cellsRat mesangial cell growthCell growthPDGF isoforms AASubunitsMatrix environmentCell proliferationPDGF isoformsReceptor subunitsUltrastructural analysisSurface expression
1992
The cardiac conduction system in the rat expresses the alpha 2 and alpha 3 isoforms of the Na+,K(+)-ATPase.
Zahler R, Brines M, Kashgarian M, Benz E, Gilmore-Hebert M. The cardiac conduction system in the rat expresses the alpha 2 and alpha 3 isoforms of the Na+,K(+)-ATPase. Proceedings Of The National Academy Of Sciences Of The United States Of America 1992, 89: 99-103. PMID: 1309618, PMCID: PMC48183, DOI: 10.1073/pnas.89.1.99.Peer-Reviewed Original ResearchConceptsAlpha 3 isoformAlpha 2Gene expression approachAlpha 1 isoformIsoform genesSpecific hybridization signalAlpha subunitSpecific expressionMembrane channelsSpecific membrane channelsHybridization signalsIsoformsWorking myocytesCardiac conduction systemExcitable tissuesSodium pumpGenesSubunitsATPaseTissueExpressionStrands