1986
Postischemic hemodynamics and recovery of renal adenosine triphosphate
Gaudio K, Stromski M, Thulin G, Ardito T, Kashgarian M, Siegel N. Postischemic hemodynamics and recovery of renal adenosine triphosphate. American Journal Of Physiology 1986, 251: f603-f609. PMID: 3490185, DOI: 10.1152/ajprenal.1986.251.4.f603.Peer-Reviewed Original ResearchConceptsRenal blood flowIschemic acute renal injuryImportant pathophysiological componentRenal ATP levelsAcute renal injuryInfusion of dopamineSaline-treated ratsPostischemic enhancementRenal adenosineRenal vasoconstrictionRenal injuryTubular functionPathophysiological componentPostischemic infusionInulin clearanceATP-MgCl2Vasoactive compoundsTubular epitheliumBlood flowPharmacological agentsPostischemic hemodynamicsTubular cellsSaline ratsEnhances recoveryRats
1984
HEMODYNAMIC EFFECT OF POST-ISCHEMIC ATP-MGCL2
Gaudio K, Thulin G, Kashgarian M, Siegel N. HEMODYNAMIC EFFECT OF POST-ISCHEMIC ATP-MGCL2. Pediatric Research 1984, 18: 362-362. DOI: 10.1203/00006450-198404001-01613.Peer-Reviewed Original ResearchRenal blood flowHemodynamic effectsATP-MgCl2Normal salineBlood flowInitial hemodynamic effectsAcute renal failureInfusion of dopamineRenal failureRenal ischemiaPostischemic infusionInulin clearanceVasoactive compoundsTubular cellsSalutary effectsCINInfusionHrDopamineCellular metabolismIschemiaInjuryRatsSalineClearance
1980
ISCHEMIC ACUTE RENAL FAILURE: ENHANCED RECOVERY OF SUPERFICIAL NEPHRON FUNCTION BY ATP-MGCL2
Gaudio K, Sieqel N, Chaudry I, Kashgarian M. ISCHEMIC ACUTE RENAL FAILURE: ENHANCED RECOVERY OF SUPERFICIAL NEPHRON FUNCTION BY ATP-MGCL2. Pediatric Research 1980, 14: 1017-1017. DOI: 10.1203/00006450-198008000-00261.Peer-Reviewed Original ResearchSuperficial single nephron GFRWhole kidney GFRIntratubular obstructionATP-MgCl2Superficial nephronsHemodynamic factorsBilateral renal artery occlusionCortical blood flow distributionTotal renal blood flowControl valuesIschemic renal insultRenal artery occlusionRenal blood flowSingle nephron GFRBlood flow distributionProximal tubular pressureRenal insultArtery occlusionNephron GFREnhancement of recoveryKidney GFRBlood flowEnhanced recoveryNormal valuesGFRRenal perfusion and intratubular pressure during ureteral occlusion in the rat
Gaudio K, Siegel N, Hayslett J, Kashgarian M. Renal perfusion and intratubular pressure during ureteral occlusion in the rat. American Journal Of Physiology 1980, 238: f205-f209. PMID: 7369362, DOI: 10.1152/ajprenal.1980.238.3.f205.Peer-Reviewed Original ResearchConceptsTotal renal blood flowBilateral ureteral occlusionBody wt-1Tubular hydrostatic pressureUreteral occlusionKidney 1WT-1Renal blood flowRenal hemodynamicsRenal perfusionIntratubular pressureBlood flowControl animalsSustained increasePeak riseOcclusionMmHgIndomethacinSubsequent time intervalsRatsPatterns of changeAlterationsAnimalsPrimary roleSubsequent time periods
1977
Renal function and cortical blood flow during the recovery phase of acute renal failure
Siegel N, Gunstream S, Handler R, Kashgarian M. Renal function and cortical blood flow during the recovery phase of acute renal failure. Kidney International 1977, 12: 199-204. PMID: 926611, DOI: 10.1038/ki.1977.101.Peer-Reviewed Original ResearchConceptsTotal renal blood flowGlomerular filtration rateAcute renal failureCortical blood flowRenal failureRenal functionBlood flowSham-injected control animalsOuter cortexOuter cortical perfusionRenal blood flowRecovery phaseCortical perfusionTubular functionSignificant diuresisFiltration rateInulin clearanceControl animalsDay 4Control valuesAbsolute perfusionProgressive improvementCortexEarly recovery phaseParallel increaseRenal cortical blood flow distribution in obstructive nephropathy in rats.
Siegel N, Feldman R, Lytton B, Hayslett J, Kashgarian M. Renal cortical blood flow distribution in obstructive nephropathy in rats. Circulation Research 1977, 40: 379-384. PMID: 844151, DOI: 10.1161/01.res.40.4.379.Peer-Reviewed Original ResearchConceptsCortical blood flow distributionBilateral ureteral occlusionUnilateral ureteral occlusionRenal blood flowGlomerular filtration rateOuter cortical perfusionBlood flow distributionCortical perfusionObstructive nephropathyUreteral occlusionRenal cortical blood flow distributionRelease of obstructionIntrarenal hemodynamicsCortical ischemiaUUO ratsRapid normalizationFiltration ratePostobstructive diuresisBlood flowComplete returnRapid returnObstructionRatsNormal patternNephropathyRENAL BLOOD FLOW AND GLOMERULAR PERFUSION DURING URETERAL OCCLUSION
Siegel N, Gunatream S, Kashgarian M. RENAL BLOOD FLOW AND GLOMERULAR PERFUSION DURING URETERAL OCCLUSION. Pediatric Research 1977, 11: 557-557. DOI: 10.1203/00006450-197704000-01125.Peer-Reviewed Original ResearchRenal blood flowGlomerular perfusionUreteral occlusionSuperficial cortexBlood flowObstructive nephropathyTotal renal blood flowBilateral ureteral occlusionRadioactive microsphere techniqueSham operated control animalsGlomerular hypoperfusionCortical ischemiaOperated control animalsCortical perfusionRenal injuryComplete ureteral occlusionMicrosphere techniqueSham operationControl animalsDeep cortexPerfusionControl valuesGlomerular countCortexOcclusion