1989
Protection of the kidney against ischemic injury by inhibition of 5'-nucleotidase
Van Waarde A, Stromski M, Thulin G, Gaudio K, Kashgarian M, Shulman R, Siegel N. Protection of the kidney against ischemic injury by inhibition of 5'-nucleotidase. American Journal Of Physiology 1989, 256: f298-f305. PMID: 2537026, DOI: 10.1152/ajprenal.1989.256.2.f298.Peer-Reviewed Original ResearchConceptsRenal ischemic insultResidual nucleotide poolMin of ischemiaRenal ATP contentFunctional recoveryIschemic injuryIschemic insultKidney functionRenal ischemiaIntramuscular injectionUntreated ratsRapid initial recoveryATP restorationRat kidneyRenal ATPIschemiaInitial recoveryKidneyRatsATP contentInsultFunctional consequencesNucleotide poolMagnetic resonanceAMPCP
1988
Metabolic and functional consequences of inhibiting adenosine deaminase during renal ischemia in rats.
Stromski M, van Waarde A, Avison M, Thulin G, Gaudio K, Kashgarian M, Shulman R, Siegel N. Metabolic and functional consequences of inhibiting adenosine deaminase during renal ischemia in rats. Journal Of Clinical Investigation 1988, 82: 1694-1699. PMID: 3263396, PMCID: PMC442739, DOI: 10.1172/jci113782.Peer-Reviewed Original ResearchConceptsPostischemic restorationFunctional recoveryBilateral renal artery occlusionAdenosine deaminaseResidual nucleotide poolRenal artery occlusionEnd of ischemiaMin of ischemiaMin of reflowArtery occlusionAdenine nucleotide poolPostischemic recoveryRenal ischemiaNucleotide poolIschemia resultsUntreated animalsDegradation of ATPIschemiaBasal levelsRenal ATPATP levelsInitial recoveryRatsInsultFunctional consequences
1980
ISCHEMIC ACUTE RENAL FAILURE: DELAYED INFUSION OF ATP-MGCL2
Siegel N, Taylor M, Gaudio K, Chaudry I, Kashgarian M. ISCHEMIC ACUTE RENAL FAILURE: DELAYED INFUSION OF ATP-MGCL2. Pediatric Research 1980, 14: 1017-1017. DOI: 10.1203/00006450-198008000-00262.Peer-Reviewed Original ResearchMinutes of ischemiaATP-MgCl2Normal salineIschemic insultBilateral renal artery occlusionModerate ischemic insultRenal artery occlusionInfusion of ATPDelayed infusionRenal injuryArtery occlusionIschemic injuryRenal ischemiaInitial injuryInitial insultInulin clearanceInjuryIschemiaInfusionInsultCINAnimalsMinutesHoursPrevious studies