2001
Differential Activation of the STAT Pathway by Angiotensin II via Angiotensin Type 1 and Type 2 Receptors in Cultured Human Fetal Mesangial Cells
Seebach F, Welte T, Fu X, Block L, Kashgarian M. Differential Activation of the STAT Pathway by Angiotensin II via Angiotensin Type 1 and Type 2 Receptors in Cultured Human Fetal Mesangial Cells. Experimental And Molecular Pathology 2001, 70: 265-273. PMID: 11418005, DOI: 10.1006/exmp.2001.2361.Peer-Reviewed Original ResearchMeSH KeywordsAngiotensin IICells, CulturedDNA-Binding ProteinsFetusGlomerular MesangiumHumansKineticsMilk ProteinsPhosphorylationProtein TransportReceptor, Angiotensin, Type 1Receptor, Angiotensin, Type 2Receptors, AngiotensinSTAT1 Transcription FactorSTAT2 Transcription FactorSTAT5 Transcription FactorTrans-ActivatorsConceptsDNA-binding activityHuman mesangial cellsStat5 DNA-binding activityNuclear translocationSTAT-DNA bindingAngiotensin IISTAT5 tyrosine phosphorylationElectromobility shift assaysReceptor subtype-specific mannerMesangial cellsReceptor-specific signalingSTAT proteinsTyrosine phosphorylationShift assaysTranscription pathwayHuman fetal mesangial cellsSignal transducerSubtype-specific mannerCellular responsesSTAT pathwayAngiotensin receptor type 2Renal mesangial cellsAngiotensin II resultsVasoactive peptide angiotensin IIPossible regulator
1994
A granulocyte inhibitory protein overexpressed in chronic renal disease regulates expression of interleukin 6 and interleukin 8.
Ziesche R, Roth M, Papakonstantinou E, Nauck M, Hörl W, Kashgarian M, Block L. A granulocyte inhibitory protein overexpressed in chronic renal disease regulates expression of interleukin 6 and interleukin 8. Proceedings Of The National Academy Of Sciences Of The United States Of America 1994, 91: 301-305. PMID: 8278382, PMCID: PMC42935, DOI: 10.1073/pnas.91.1.301.Peer-Reviewed Original ResearchConceptsGranulocyte inhibitory proteinsInterleukin-6Chronic renal diseaseChronic renal failureProgression of glomerulosclerosisHuman mesangial cellsInhibitory proteinPluripotential effectsRenal failureRenal diseaseCytokine expressionIL-6IL-8Interleukin-8Inflammatory reactionGIP resultsGlomerular responseMesangial cellsC-jun mRNAC-fos geneC-JunDe novo synthesisNovo synthesisExpressionOverall effectTransforming growth factor-beta 1 stimulates glomerular mesangial cell synthesis of the 72-kd type IV collagenase.
Marti H, Lee L, Kashgarian M, Lovett D. Transforming growth factor-beta 1 stimulates glomerular mesangial cell synthesis of the 72-kd type IV collagenase. American Journal Of Pathology 1994, 144: 82-94. PMID: 8291614, PMCID: PMC1887110.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBase SequenceBlotting, NorthernCells, CulturedCollagenasesEnzyme-Linked Immunosorbent AssayGlomerular MesangiumHumansImmunohistochemistryMatrix Metalloproteinase 9Molecular ProbesMolecular Sequence DataNephritisRatsRats, WistarTranscription, GeneticTransforming Growth Factor betaConceptsType IV collagenaseHuman mesangial cellsType IVMesangial cellsImmune complex-mediated glomerulonephritisMRNA expressionType IV collagenase mRNA expressionCultured human mesangial cellsCollagenase mRNA expressionMesangial cell synthesisGlomerular inflammatory processesTIMP-1 synthesisNephritic ratsInflammatory processGlomerular matrixMesangial distributionMatrix protein synthesisTIMP-1Direct stimulationTissue inhibitorNormal animalsMesangial compartmentMatrix metalloproteinase synthesisStimulatory effectTIMP-1 inhibitor