2019
Urine TNF-α and IL-9 for clinical diagnosis of acute interstitial nephritis
Moledina DG, Wilson FP, Pober JS, Perazella MA, Singh N, Luciano RL, Obeid W, Lin H, Kuperman M, Moeckel GW, Kashgarian M, Cantley LG, Parikh CR. Urine TNF-α and IL-9 for clinical diagnosis of acute interstitial nephritis. JCI Insight 2019, 4: e127456. PMID: 31092735, PMCID: PMC6542610, DOI: 10.1172/jci.insight.127456.Peer-Reviewed Original ResearchConceptsAcute interstitial nephritisAcute kidney diseasePrebiopsy diagnosisKidney biopsyKidney diseaseIL-9AIN diagnosisUrine TNFInterstitial nephritisSpecific T cell subsetsAcute tubular injuryDiabetic kidney diseaseIL-9 levelsTNF-α levelsT cell subsetsAddition of biomarkersPlasma cytokinesCytokine levelsTubular injuryHighest quartileMultivariable analysisCell subsetsUrinary TNFBlood eosinophilsGlomerular disease
2008
Disruption of Myosin 1e Promotes Podocyte Injury
Krendel M, Kim SV, Willinger T, Wang T, Kashgarian M, Flavell RA, Mooseker MS. Disruption of Myosin 1e Promotes Podocyte Injury. Journal Of The American Society Of Nephrology 2008, 20: 86-94. PMID: 19005011, PMCID: PMC2615733, DOI: 10.1681/asn.2007111172.Peer-Reviewed Original ResearchConceptsChronic renal injuryNormal glomerular filtrationGlomerular basement membraneRenal injuryKidney inflammationPodocyte foot processesGlomerular diseasePodocyte injuryGlomerular filtrationRenal tissueFoot processesPodocyte functionBasement membraneInjuryUltrastructural levelDiseaseMiceType IProteinuriaInflammationKidneyImportant rolePodocytes
1992
The pathobiology of the mesangium
Kashgarian M, Sterzel R. The pathobiology of the mesangium. Kidney International 1992, 41: 524-529. PMID: 1573822, DOI: 10.1038/ki.1992.74.Peer-Reviewed Original ResearchConceptsGlomerular diseaseAdvanced glomerular lesionsProgressive glomerular diseaseGlomerular capillary tuftDiabetic nephropathyIgA nephropathyMesangiocapillary glomerulonephritisGlomerular lesionsHistologic abnormalitiesGlomerular morphologySegmental glomerulosclerosisChronic diseasesSclerotic responseProliferative responseEpithelial cell layerMesangial matrixMesangial cellsCapillary tuftMesangiumDiseaseNephropathyCell layerObvious involvementPathobiologyMammalian kidney
1982
The mesangium and glomerulonephritis
Sterzel R, Lovett D, Stein H, Kashgarian M. The mesangium and glomerulonephritis. Journal Of Molecular Medicine 1982, 60: 1077-1094. PMID: 7144055, DOI: 10.1007/bf01715838.Peer-Reviewed Original ResearchConceptsGlomerular diseaseImmune competent cellsProgressive glomerular sclerosisExperimental glomerular diseaseMesangial cell proliferationMesangial spacePeripheral capillary wallsCertain glomerular diseasesLocal hemodynamic factorsIntrinsic mesangial cellsGlomerular basement membraneMesangial dysfunctionGlomerular sclerosisInflammatory cellsGlomerular hypertensionHistopathologic studyMarked proteinuriaGlomerular disordersSubendothelial depositsPericapillary tissueTherapeutic approachesImmune complexesFunctional damageMesangial abnormalitiesCapillary pericytes