2020
NMDAR-Dependent Emergence of Behavioral Representation in Primary Visual Cortex
Puścian A, Benisty H, Higley MJ. NMDAR-Dependent Emergence of Behavioral Representation in Primary Visual Cortex. Cell Reports 2020, 32: 107970. PMID: 32726633, PMCID: PMC7431963, DOI: 10.1016/j.celrep.2020.107970.Peer-Reviewed Original ResearchConceptsPrimary visual cortexVisual cortexNMDA-type glutamate receptorsNeocortical sensory areasFunctional plasticityConsiderable functional plasticityPyramidal cellsGlutamate receptorsCell-autonomous expressionV1 neuronsVisual task performanceSensory areasExperience-dependent emergenceCortical networksBehavioral outputCortexVisual inputBehavioral demandsMiceNeuronsReceptors
2019
Simultaneous mesoscopic and two-photon imaging of neuronal activity in cortical circuits
Barson D, Hamodi AS, Shen X, Lur G, Constable RT, Cardin JA, Crair MC, Higley MJ. Simultaneous mesoscopic and two-photon imaging of neuronal activity in cortical circuits. Nature Methods 2019, 17: 107-113. PMID: 31686040, PMCID: PMC6946863, DOI: 10.1038/s41592-019-0625-2.Peer-Reviewed Original ResearchConceptsVasoactive intestinal peptide-expressing interneuronsBrain-wide network dynamicsTwo-photon calcium imagingEntire cortical mantleLocal neuronal circuitsLong-range cortical networksWidespread gene deliveryWidefield calciumPyramidal neuronsAwake miceCortical circuitsNeuronal activityCortical mantleTwo-photon imagingViral transduction methodsNeuronal circuitsCalcium imagingMouse brainFunctional connectivityLocal microcircuitsMammalian cortexCortical architectureCortical networksBrainActivity propagates