2019
Layer 5 Circuits in V1 Differentially Control Visuomotor Behavior
Tang L, Higley MJ. Layer 5 Circuits in V1 Differentially Control Visuomotor Behavior. Neuron 2019, 105: 346-354.e5. PMID: 31757603, PMCID: PMC6981039, DOI: 10.1016/j.neuron.2019.10.014.Peer-Reviewed Original ResearchConceptsPyramidal neuronsNeocortical sensory areasPrimary visual cortexDistinct brain areasEyeblink conditioning taskCorticopontine neuronsAxonal projectionsBrain areasCortical subnetworksVisual cortexCalcium imagingVisuomotor behaviorSensory areasOptogenetic manipulationNeuronsConditioning taskDistinct targetsCortexMice
2013
Compartmentalization of GABAergic Inhibition by Dendritic Spines
Chiu CQ, Lur G, Morse TM, Carnevale NT, Ellis-Davies GC, Higley MJ. Compartmentalization of GABAergic Inhibition by Dendritic Spines. Science 2013, 340: 759-762. PMID: 23661763, PMCID: PMC3752161, DOI: 10.1126/science.1234274.Peer-Reviewed Original ResearchConceptsGABAergic inhibitionDendritic spinesPerisomatic inhibitory synapsesPyramidal cell dendritesTwo-photon calcium imagingAction potential outputAcid-mediated inhibitionIndividual dendritic spinesGABAergic controlGABAergic synapsesPyramidal neuronsCell dendritesInhibitory synapsesNeuronal activityCalcium imagingSpine headsInhibitory actionNeocortexInhibitionSpineSynapsesCompartmentalized controlCritical roleSignalingPostsynaptic