2024
Traumatic brain injury disrupts state-dependent functional cortical connectivity in a mouse model
Bottom-Tanzer S, Corella S, Meyer J, Sommer M, Bolaños L, Murphy T, Quiñones S, Heiney S, Shtrahman M, Whalen M, Oren R, Higley M, Cardin J, Noubary F, Armbruster M, Dulla C. Traumatic brain injury disrupts state-dependent functional cortical connectivity in a mouse model. Cerebral Cortex 2024, 34: bhae038. PMID: 38365273, PMCID: PMC11486687, DOI: 10.1093/cercor/bhae038.Peer-Reviewed Original ResearchConceptsControlled cortical impactTraumatic brain injuryFunctional connectivityDisrupted functional connectivityAssociated with improved cognitionReduced theta powerBrain injuryHuman TBI patientsModel of traumatic brain injuryBehavioral state-dependent changesNetwork connectivity changesFunctional cortical connectivityBrain regionsTheta powerConnectivity changesState-dependent changesCortical impactPeriods of locomotionCortical connectivityTBI patientsRodent modelsECoG activityMotor dysfunctionCortexInjured cortex
2019
Simultaneous mesoscopic and two-photon imaging of neuronal activity in cortical circuits
Barson D, Hamodi AS, Shen X, Lur G, Constable RT, Cardin JA, Crair MC, Higley MJ. Simultaneous mesoscopic and two-photon imaging of neuronal activity in cortical circuits. Nature Methods 2019, 17: 107-113. PMID: 31686040, PMCID: PMC6946863, DOI: 10.1038/s41592-019-0625-2.Peer-Reviewed Original ResearchConceptsVasoactive intestinal peptide-expressing interneuronsBrain-wide network dynamicsTwo-photon calcium imagingEntire cortical mantleLocal neuronal circuitsLong-range cortical networksWidespread gene deliveryWidefield calciumPyramidal neuronsAwake miceCortical circuitsNeuronal activityCortical mantleTwo-photon imagingViral transduction methodsNeuronal circuitsCalcium imagingMouse brainFunctional connectivityLocal microcircuitsMammalian cortexCortical architectureCortical networksBrainActivity propagates