2024
Multimodal measures of spontaneous brain activity reveal both common and divergent patterns of cortical functional organization
Vafaii H, Mandino F, Desrosiers-Grégoire G, O’Connor D, Markicevic M, Shen X, Ge X, Herman P, Hyder F, Papademetris X, Chakravarty M, Crair M, Constable R, Lake E, Pessoa L. Multimodal measures of spontaneous brain activity reveal both common and divergent patterns of cortical functional organization. Nature Communications 2024, 15: 229. PMID: 38172111, PMCID: PMC10764905, DOI: 10.1038/s41467-023-44363-z.Peer-Reviewed Original Research
2023
Rapid fluctuations in functional connectivity of cortical networks encode spontaneous behavior
Benisty H, Barson D, Moberly A, Lohani S, Tang L, Coifman R, Crair M, Mishne G, Cardin J, Higley M. Rapid fluctuations in functional connectivity of cortical networks encode spontaneous behavior. Nature Neuroscience 2023, 27: 148-158. PMID: 38036743, PMCID: PMC11316935, DOI: 10.1038/s41593-023-01498-y.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrain MappingMagnetic Resonance ImagingMiceNeocortexNeural PathwaysNeuronsWakefulnessConceptsFunctional connectivitySpontaneous behaviorCortical networksCortical network activityTime-varying functional connectivityFunctional magnetic resonanceCerebral cortexAwake miceDynamic functional connectivityAwake animalsNeighboring neuronsPatterned activityDistinct behavioral statesTwo-photon microscopyNeural activityCortical signalsBehavioral statesCortexNetwork activityCortical dynamicsMagnetic resonance
2020
Simultaneous cortex-wide fluorescence Ca2+ imaging and whole-brain fMRI
Lake EMR, Ge X, Shen X, Herman P, Hyder F, Cardin JA, Higley MJ, Scheinost D, Papademetris X, Crair MC, Constable RT. Simultaneous cortex-wide fluorescence Ca2+ imaging and whole-brain fMRI. Nature Methods 2020, 17: 1262-1271. PMID: 33139894, PMCID: PMC7704940, DOI: 10.1038/s41592-020-00984-6.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBlood Gas AnalysisBrain MappingCalciumCalcium-Binding ProteinsCerebral CortexFluorescenceGreen Fluorescent ProteinsMagnetic Resonance ImagingMiceMice, TransgenicOxygenConceptsOptical measurementsBrain functionTransgenic murine modelFunctional magnetic resonance imagingMagnetic resonance imagingFluorescent measuresWhole-brain fMRIMurine modelResonance imagingFluorescence Ca2Human brain functionConnectivity strengthBOLD signalBrain activityWidefieldLow frequencyImagingModalitiesTransfer functionMeasurementsCortex