Visual Circuit Development Requires Patterned Activity Mediated by Retinal Acetylcholine Receptors
Burbridge TJ, Xu HP, Ackman JB, Ge X, Zhang Y, Ye MJ, Zhou ZJ, Xu J, Contractor A, Crair MC. Visual Circuit Development Requires Patterned Activity Mediated by Retinal Acetylcholine Receptors. Neuron 2014, 84: 1049-1064. PMID: 25466916, PMCID: PMC4258148, DOI: 10.1016/j.neuron.2014.10.051.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAge FactorsAnalysis of VarianceAnimalsAnimals, NewbornCalciumCyclic AMPCyclic GMPCyclooxygenase InhibitorsEye ProteinsFunctional LateralityHomeodomain ProteinsIn Vitro TechniquesMeclofenamic AcidMiceMice, TransgenicPaired Box Transcription FactorsPAX6 Transcription FactorReceptors, NicotinicRepressor ProteinsRetinaRetinal Ganglion CellsRNA, MessengerVisual PathwaysConceptsRetinal wavesCircuit refinementNervous systemNeural circuitsVisual circuit developmentSpontaneous retinal activityRetinal activityRetinorecipient regionsSpontaneous activityAcetylcholine receptorsPharmacological manipulationVisual circuitsSynaptic connectionsVertebrate nervous systemNeural activityOnset of sensationAltered patternCircuit developmentSensory systemsCausal linkEarly developmentActivityBrainReceptorsStructural organization and function of mouse photoreceptor ribbon synapses involve the immunoglobulin protein synaptic cell adhesion molecule 1
Ribic A, Liu X, Crair MC, Biederer T. Structural organization and function of mouse photoreceptor ribbon synapses involve the immunoglobulin protein synaptic cell adhesion molecule 1. The Journal Of Comparative Neurology 2014, 522: 900-920. PMID: 23982969, PMCID: PMC3947154, DOI: 10.1002/cne.23452.Peer-Reviewed Original ResearchMeSH KeywordsAlcohol OxidoreductasesAnalysis of VarianceAnimalsAnimals, NewbornCell Adhesion Molecule-1Cell Adhesion MoleculesCo-Repressor ProteinsDNA-Binding ProteinsElectroretinographyFemaleGene Expression Regulation, DevelopmentalImmunoglobulinsMaleMiceMice, Inbred C57BLMice, KnockoutMicroscopy, ImmunoelectronNerve Tissue ProteinsPhosphoproteinsReceptors, Metabotropic GlutamateRetinaRetinal Rod Photoreceptor CellsSynapsesVesicular Glutamate Transport Protein 1ConceptsCell adhesion molecule-1Adhesion molecule-1Ribbon synapsesKO retinasSynaptic cell adhesion molecule 1Molecule-1Mouse photoreceptor ribbon synapsesInner retinal layersPhotoreceptor ribbon synapsesRod visual pathwayEarly postnatal stagesPlexiform layerKO micePhotoreceptor synapsesSynaptic organizationExcitatory synapsesQuantitative ultrastructural analysisRetinal layersKnockout miceOuter nuclearVisual pathwaySynapse developmentElectroretinogram recordingsPostnatal stagesAdhesion molecules