2020
Dogs and pigs are transport hosts of Necator americanus: Molecular evidence for a zoonotic mechanism of human hookworm transmission in Ghana
Boyko RH, Harrison L, Humphries D, Galvani AP, Townsend JP, Otchere J, Wilson MD, Cappello M. Dogs and pigs are transport hosts of Necator americanus: Molecular evidence for a zoonotic mechanism of human hookworm transmission in Ghana. Zoonoses And Public Health 2020, 67: 474-483. PMID: 32529782, DOI: 10.1111/zph.12708.Peer-Reviewed Original ResearchConceptsPig fecal samplesProspective molecular studyNematode Toxocara canisPig ownershipPig samplesNematode larvaeAnimal faecesTransport hostsDog ownershipKintampo NorthFecal samplesToxocara canisProxy of exposureHuman infectionsPigsHookworm eggsSubsequent prospective studyHookworm transmissionDogsResource-limited countriesFaecesPCR analysisGhanaMolecular evidenceSignificant morbidity
2019
Genetic Markers of Benzimidazole Resistance among Human Hookworms (Necator americanus) in Kintampo North Municipality, Ghana.
Orr AR, Quagraine JE, Suwondo P, George S, Harrison LM, Dornas FP, Evans B, Caccone A, Humphries D, Wilson MD, Cappello M. Genetic Markers of Benzimidazole Resistance among Human Hookworms (Necator americanus) in Kintampo North Municipality, Ghana. American Journal Of Tropical Medicine And Hygiene 2019, 100: 351-356. PMID: 30734697, PMCID: PMC6367626, DOI: 10.4269/ajtmh.18-0727.Peer-Reviewed Original ResearchConceptsMass drug administrationSoil-transmitted helminthsKintampo North MunicipalitySchool-aged childrenSingle nucleotide polymorphismsPolymerase chain reactionEffectiveness of MDAWild-type SNPsInfected study subjectsPeriodic mass drug administrationResistance-associated single nucleotide polymorphismsCross-sectional studyResistance-associated mutationsWorld Health OrganizationHookworm infectionDrug exposureHookworm eggsUnreported associationStudy subjectsDrug AdministrationPosttreatment samplesChemotherapeutic approachesGrowth delayHuman hookwormHealth Organization