Polycystin-1 C-terminal Cleavage Is Modulated by Polycystin-2 Expression*
Bertuccio CA, Chapin HC, Cai Y, Mistry K, Chauvet V, Somlo S, Caplan MJ. Polycystin-1 C-terminal Cleavage Is Modulated by Polycystin-2 Expression*. Journal Of Biological Chemistry 2009, 284: 21011-21026. PMID: 19491093, PMCID: PMC2742866, DOI: 10.1074/jbc.m109.017756.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SubstitutionAmino AcidsAnimalsCalciumCell NucleusChlorocebus aethiopsCOS CellsExtracellular SpaceGenes, ReporterHumansIntracellular SpaceMiceMutant ProteinsProteasome Endopeptidase ComplexProtein Processing, Post-TranslationalProtein TransportStructure-Activity RelationshipTRPP Cation ChannelsThe uptake and intracellular fate of PLGA nanoparticles in epithelial cells
Cartiera MS, Johnson KM, Rajendran V, Caplan MJ, Saltzman WM. The uptake and intracellular fate of PLGA nanoparticles in epithelial cells. Biomaterials 2009, 30: 2790-2798. PMID: 19232712, PMCID: PMC3195413, DOI: 10.1016/j.biomaterials.2009.01.057.Peer-Reviewed Original ResearchConceptsEpithelial cellsCell linesRenal proximal tubulesType of epitheliumParticle/cell ratiosCaco-2 cellsEpithelial cell lineIntracellular fateProximal tubulesRespiratory airwaysCell ratioImmunofluorescence techniqueOK cellsDifferent epithelial cell linesEndoplasmic reticulumConfocal analysisMajor targetConfocal microscopyExtent of uptakeCellsParticle uptakeEarly endosomesCellular uptakePLGA nanoparticlesUptake