2022
Results from part A of the multi-center, double-blind, randomized, placebo-controlled NefIgArd trial, which evaluated targeted-release formulation of budesonide for the treatment of primary immunoglobulin A nephropathy
Barratt J, Lafayette R, Kristensen J, Stone A, Cattran D, Floege J, Tesar V, Trimarchi H, Zhang H, Eren N, Paliege A, Rovin B, Fragale G, Karl A, Losisolo P, Trimarchi H, Hoyos I, Lampo M, Monkowski M, De La Fuente J, Alvarez M, Stoppa D, Chiurchiu C, Novoa P, Orias M, Barron M, Giotto A, Arriola M, Cassini E, Maldonado R, Dionisi M, Ryan J, Toussaint N, Luxton G, Peh C, Levidiotis V, Francis R, Phoon R, Fedosiuk E, Toropilov D, Yakubtsevich R, Mikhailova E, Bovy C, Demoulin N, Hougardy J, Maes B, Speeckaert M, Laurin L, Barbour S, Masse M, Hladunewich M, Reich H, Cournoyer S, Tennankore K, Barbour S, Lv J, Liu Z, Wang C, Li S, Luo Q, Ni Z, Yan T, Fu P, Cheng H, Liu B, Lu W, Wang J, Chen Q, Wang D, Xiong Z, Chen M, Xu Y, Wei J, Pai P, Chen L, Rehorova J, Maixnerova D, Safranek R, Rychlik I, Hruby M, Makela S, Vaaraniemi K, Ortiz F, Alamartine E, Daroux M, Cartery C, Vrtovsnik F, Serre J, Stamellou E, Vielhauer V, Hugo C, Budde K, Otte B, Nitschke M, Ntounousi E, Boletis I, Papagianni A, Goumenos D, Stylianou K, Zermpala S, Esposito C, Cozzolino M, Viganò S, Gesualdo L, Nowicki M, Stompor T, Kurnatowska I, Kim S, Kim Y, Na K, Kim D, Kim S, Porras L, Garcia E, Pamplona I, Segarra A, Goicoechea M, Fellstrom B, Lundberg S, Hemmingsson P, Guron G, Sandell A, Chen C, Tokgoz B, Duman S, Altiparmak M, Ergul M, Maxwell P, Mark P, McCafferty K, Khwaja A, Cheung C, Hall M, Power A, Kanigicherla D, Baker R, Moriarty J, Mohamed A, Aiello J, Canetta P, Ayoub I, Robinson D, Thakar S, Mottl A, Sachmechi I, Fischbach B, Singh H, Mulhern J, Kamal F, Linfert D, Rizk D, Wadhwani S, Sarav M, Campbell K, Coppock G, Luciano R, Sedor J, Avasare R, Lau W. Results from part A of the multi-center, double-blind, randomized, placebo-controlled NefIgArd trial, which evaluated targeted-release formulation of budesonide for the treatment of primary immunoglobulin A nephropathy. Kidney International 2022, 103: 391-402. PMID: 36270561, DOI: 10.1016/j.kint.2022.09.017.Peer-Reviewed Original ResearchConceptsTreatment-emergent adverse eventsSecondary efficacy outcomesTwo-part trialGlomerular filtration rateMonths of treatmentPart AEGFR preservationOral budesonidePrimary IgANEfficacy outcomesNephropathy TrialPrimary endpointAdult patientsAdverse eventsCreatinine ratioIgA nephropathyKidney failureUrine proteinFiltration ratePlaceboTherapeutic potentialPrimary immunoglobulinUPCRMonthsTrials
2020
Acute Kidney Injury Incidence in Hospitalized Patients and Implications for Nutrition Support
Meyer D, Mohan A, Subev E, Sarav M, Sturgill D. Acute Kidney Injury Incidence in Hospitalized Patients and Implications for Nutrition Support. Nutrition In Clinical Practice 2020, 35: 987-1000. PMID: 33140897, DOI: 10.1002/ncp.10595.Peer-Reviewed Original ResearchConceptsAcute kidney injuryAdult patientsRates of acute kidney injuryHospitalized patientsAcute kidney injury incidenceManagement of acute kidney injuryMultiple nutritional problemsAdequate nutritional supportHospitalized adult patientsKidney injuryNutritional supportPatientsNutritional problemsIncidenceInjury incidence
2014
A Technology-Based Quality Innovation to Identify Undiagnosed Hypertension Among Active Primary Care Patients
Rakotz M, Ewigman B, Sarav M, Ross R, Robicsek A, Konchak C, Gavagan T, Baker D, Hyman D, Anderson K, Masi C. A Technology-Based Quality Innovation to Identify Undiagnosed Hypertension Among Active Primary Care Patients. The Annals Of Family Medicine 2014, 12: 352-358. PMID: 25024244, PMCID: PMC4096473, DOI: 10.1370/afm.1665.Peer-Reviewed Original ResearchConceptsPrimary care patientsQuality improvement initiativesElectronic health recordsUndiagnosed hypertensionAt-risk patientsCare patientsImprovement initiativesContinuous quality improvement initiativesPrimary care practicesIntegrated health systemQuality improvement processPhase 1Blood pressureFollow-up periodAutomated office blood pressureDiagnosis of hypertensionTechnology-based strategiesPhase 2Evaluate at-risk patientsCare practicesPhysician feedbackComputer alertsHealth recordsHealth systemElevated blood pressure