2020
The Lung Microbiome and Pneumonia
Pettigrew MM, Tanner W, Harris AD. The Lung Microbiome and Pneumonia. The Journal Of Infectious Diseases 2020, 223: s241-s245. PMID: 33330898, DOI: 10.1093/infdis/jiaa702.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2018
Gastrointestinal Microbiota Disruption and Risk of Colonization With Carbapenem-resistant Pseudomonas aeruginosa in Intensive Care Unit Patients
Pettigrew MM, Gent JF, Kong Y, Halpin AL, Pineles L, Harris AD, Johnson JK. Gastrointestinal Microbiota Disruption and Risk of Colonization With Carbapenem-resistant Pseudomonas aeruginosa in Intensive Care Unit Patients. Clinical Infectious Diseases 2018, 69: 604-613. PMID: 30383203, PMCID: PMC6669284, DOI: 10.1093/cid/ciy936.Peer-Reviewed Original ResearchConceptsCarbapenem-resistant Pseudomonas aeruginosaIntensive care unit patientsCare unit patientsPiperacillin-tazobactamUnit patientsICU patientsMarker of riskMaryland Medical CenterRisk of colonizationRibosomal RNA gene sequencingRNA gene sequencingAdmission swabCRPA infectionPseudomonas aeruginosaICU admissionPatient characteristicsMicrobiota disruptionMedical CenterGastrointestinal tractAdditional swabsAntimicrobial exposureLower riskEvaluated associationsPatientsProtective role
2017
Risk Factors and Outcomes Associated with Multidrug-Resistant Acinetobacter baumannii upon Intensive Care Unit Admission
Blanco N, Harris AD, Rock C, Johnson JK, Pineles L, Bonomo RA, Srinivasan A, Pettigrew MM, Thom KA. Risk Factors and Outcomes Associated with Multidrug-Resistant Acinetobacter baumannii upon Intensive Care Unit Admission. Antimicrobial Agents And Chemotherapy 2017, 62: 10.1128/aac.01631-17. PMID: 29133567, PMCID: PMC5740370, DOI: 10.1128/aac.01631-17.Peer-Reviewed Original ResearchConceptsMedical intensive care unitSurgical intensive care unitIntensive care unitICU admissionRisk factorsCare unitIntensive care unit admissionBroad-spectrum antibiotic useMultidrug-resistant Acinetobacter baumanniiPositive clinical cultureCare unit admissionRetrospective cohort analysisAssociated risk factorsEmpirical antibiotic selectionInfection control practicesPrevalence of MDRMaryland Medical CenterPerirectal surveillance culturesImportant nosocomial pathogenUnit admissionAdult patientsICU typePrevious admissionsCurrent hospitalizationActive surveillance
2016
The human microbiota: novel targets for hospital-acquired infections and antibiotic resistance
Pettigrew MM, Johnson JK, Harris AD. The human microbiota: novel targets for hospital-acquired infections and antibiotic resistance. Annals Of Epidemiology 2016, 26: 342-347. PMID: 26994507, PMCID: PMC4892961, DOI: 10.1016/j.annepidem.2016.02.007.Peer-Reviewed Original ResearchConceptsMultidrug-resistant organismsSpread of MDROsInfection control interventionsHealth care settingsCare settingsColonization resistanceControl interventionsTraditional infection control measuresInfection control measuresAntibiotic resistanceControl of MDROsHospital-acquired infectionsHealth care professionalsHospitalized patientsIntact microbiotaAntibiotic useMDRO transmissionEpidemiologic studiesInfection controlAntimicrobial stewardshipCare professionalsHealthy microbiotaExpansion of pathogensResistant organismsNovel targetPseudomonas aeruginosa Colonization in the Intensive Care Unit: Prevalence, Risk Factors, and Clinical Outcomes
Harris AD, Jackson SS, Robinson G, Pineles L, Leekha S, Thom KA, Wang Y, Doll M, Pettigrew MM, Johnson JK. Pseudomonas aeruginosa Colonization in the Intensive Care Unit: Prevalence, Risk Factors, and Clinical Outcomes. Infection Control And Hospital Epidemiology 2016, 37: 544-548. PMID: 26832307, PMCID: PMC4833506, DOI: 10.1017/ice.2015.346.Peer-Reviewed Original ResearchConceptsIntensive care unitPseudomonas aeruginosa colonizationRisk factorsICU admissionClinical culturesCurrent hospitalizationAeruginosa colonizationCare unitIntensive care unit admissionP. aeruginosaSurgical intensive care unitPositive clinical cultureCare unit admissionEmpirical antibiotic therapyTertiary care hospitalType of ICUSignificant risk factorsP. aeruginosa colonizationRapid diagnostic testingPerirectal surveillance culturesUnit admissionCohort studyAntibiotic therapyCare hospitalClinical outcomes
2012
Controlling Antimicrobial Resistance through Targeted, Vaccine-Induced Replacement of Strains
Tekle YI, Nielsen KM, Liu J, Pettigrew MM, Meyers LA, Galvani AP, Townsend JP. Controlling Antimicrobial Resistance through Targeted, Vaccine-Induced Replacement of Strains. PLOS ONE 2012, 7: e50688. PMID: 23227198, PMCID: PMC3515573, DOI: 10.1371/journal.pone.0050688.Peer-Reviewed Original ResearchConceptsFirst clinical interventionImportant public health toolPan-resistant strainsInsufficient immune responsePublic health toolMulti-resistant strainsStaphylococcus aureus genotypesVaccine efficacyNosocomial outbreaksDrug treatmentImmune responseResistant serotypesFrequent reasonHypothetical vaccineVaccine developmentStrain replacementVaccineInfectious diseasesAureus genotypesClinical interventionsInfectionHealth toolsAntimicrobial resistanceIntervention strategiesSerotypes