2018
Changes in IgA Protease Expression Are Conferred by Changes in Genomes during Persistent Infection by Nontypeable Haemophilus influenzae in Chronic Obstructive Pulmonary Disease
Gallo MC, Kirkham C, Eng S, Bebawee RS, Kong Y, Pettigrew MM, Tettelin H, Murphy TF. Changes in IgA Protease Expression Are Conferred by Changes in Genomes during Persistent Infection by Nontypeable Haemophilus influenzae in Chronic Obstructive Pulmonary Disease. Infection And Immunity 2018, 86: 10.1128/iai.00313-18. PMID: 29760213, PMCID: PMC6056860, DOI: 10.1128/iai.00313-18.Peer-Reviewed Original ResearchConceptsChronic obstructive pulmonary diseaseObstructive pulmonary diseasePersistent infectionPulmonary diseaseIgA proteaseProtease expressionNontypeable Haemophilus influenzaeAcute exacerbationLower airwaysRespiratory tractNTHi strainsHaemophilus influenzaeInfectionNTHiNatural infectionHuman pathobiontAltered expressionPatientsDiseasePersistent strainsExpressionCritical roleExacerbationAirwayInitial acquisitionHaemophilus influenzae genome evolution during persistence in the human airways in chronic obstructive pulmonary disease
Pettigrew MM, Ahearn CP, Gent JF, Kong Y, Gallo MC, Munro JB, D’Mello A, Sethi S, Tettelin H, Murphy TF. Haemophilus influenzae genome evolution during persistence in the human airways in chronic obstructive pulmonary disease. Proceedings Of The National Academy Of Sciences Of The United States Of America 2018, 115: e3256-e3265. PMID: 29555745, PMCID: PMC5889651, DOI: 10.1073/pnas.1719654115.Peer-Reviewed Original ResearchConceptsChronic obstructive pulmonary diseaseObstructive pulmonary diseaseCandidate vaccine antigensHuman airwaysPulmonary diseaseVaccine antigensRespiratory tract pathogensHuman respiratory tractProspective studyTract pathogensNTHi isolatesRespiratory tractAnimal modelsVaccine developmentHuman infectionsAirwayNTHiSurface moleculesAmino acid sequence changesWhole-genome sequencingAntigenBacterial pathogensDiseaseSubset of strainsVirulence functions
2011
Viral-Bacterial Interactions and Risk of Acute Otitis Media Complicating Upper Respiratory Tract Infection
Pettigrew MM, Gent JF, Pyles RB, Miller AL, Nokso-Koivisto J, Chonmaitree T. Viral-Bacterial Interactions and Risk of Acute Otitis Media Complicating Upper Respiratory Tract Infection. Journal Of Clinical Microbiology 2011, 49: 3750-3755. PMID: 21900518, PMCID: PMC3209086, DOI: 10.1128/jcm.01186-11.Peer-Reviewed Original ResearchMeSH KeywordsChild, PreschoolCohort StudiesComorbidityHaemophilus influenzaeHuman bocavirusHumansInfantMetapneumovirusMicrobial InteractionsMoraxella catarrhalisOtitis MediaPolymerase Chain ReactionProspective StudiesRespiratory Syncytial VirusesRespiratory Tract InfectionsRisk AssessmentStreptococcus pneumoniaeConceptsUpper respiratory tract infectionAcute otitis mediaRespiratory tract infectionsRespiratory syncytial virusOtitis mediaOtitis media riskTract infectionsViral loadSyncytial virusHaemophilus influenzaeStreptococcus pneumoniaeRespiratory Syncytial Virus LoadMedium-risk factorsRepeated-measures logistic regressionRSV viral loadViral-bacterial interactionsHigh viral loadSpecific virusesBacterial pathogensChildren ages 6Common complicationRespiratory virusesMedium riskProspective studyHuman bocavirus
2008
Microbial Interactions during Upper Respiratory Tract Infections - Volume 14, Number 10—October 2008 - Emerging Infectious Diseases journal - CDC
Pettigrew MM, Gent JF, Revai K, Patel JA, Chonmaitree T. Microbial Interactions during Upper Respiratory Tract Infections - Volume 14, Number 10—October 2008 - Emerging Infectious Diseases journal - CDC. Emerging Infectious Diseases 2008, 14: 1584-1591. PMID: 18826823, PMCID: PMC2609881, DOI: 10.3201/eid1410.080119.Peer-Reviewed Original ResearchMeSH KeywordsChild, PreschoolCohort StudiesFemaleHaemophilus InfectionsHaemophilus influenzaeHumansInfantMaleMoraxella catarrhalisMoraxellaceae InfectionsNasopharynxOtitis MediaProspective StudiesRespiratory Tract InfectionsStaphylococcal InfectionsStaphylococcus aureusStreptococcus pneumoniaeSuperinfectionConceptsUpper respiratory tract infectionH. influenzaeInfectious Diseases journal - CDCRespiratory tract infectionsS. pneumoniae colonizationHealthy children 6Months of ageS. aureusProspective cohortTract infectionsPneumoniae colonizationVaccination strategiesAntimicrobial therapyMoraxella catarrhalisChildren 6M. catarrhalisS. pneumoniaeHaemophilus influenzaeStreptococcus pneumoniaeBacterial infectionsSpecific bacterial speciesInfluenzaeLikelihood of colonizationCatarrhalisStaphylococcus aureus
2004
Association of early‐onset otitis media in infants and exposure to household mould
Pettigrew MM, Gent JF, Triche EW, Belanger KD, Bracken MB, Leaderer BP. Association of early‐onset otitis media in infants and exposure to household mould. Paediatric And Perinatal Epidemiology 2004, 18: 441-447. PMID: 15535820, DOI: 10.1111/j.1365-3016.2004.00596.x.Peer-Reviewed Original ResearchConceptsEarly otitis mediaOtitis mediaMonths of ageHousehold moldInfant respiratory symptomsAcute otitis mediaPhysician-diagnosed asthmaCohort of infantsOtitis media episodesRecurrent otitis mediaEarly onset otitis mediaMonths of lifeQuarterly telephone interviewsRespiratory symptomsCommon infectionsProspective studyPotential confoundersHigh riskInfant's birthStandardised questionnaireTelephone interviewsMonthsAsthmaEarly childhoodFurther studiesInfant Otitis Media and the Use of Secondary Heating Sources
Pettigrew MM, Gent JF, Triche EW, Belanger KD, Bracken MB, Leaderer BP. Infant Otitis Media and the Use of Secondary Heating Sources. Epidemiology 2004, 15: 13-20. PMID: 14712142, DOI: 10.1097/01.ede.0000101292.41006.2e.Peer-Reviewed Original ResearchMeSH KeywordsEnvironmental ExposureEpidemiologic StudiesFemaleHeatingHumansInfantInfant WelfareMaleOtitis MediaProspective StudiesRecurrenceRegression AnalysisConceptsRecurrent otitis mediaOtitis media episodesOtitis mediaOtitis media riskOffice visitsDay careMaternal historyWhite raceAssociation of exposureHome heating sourcesDoctor office visitsLogistic regression modelingMedium riskProspective studyPotential confoundersMore episodesSecondary heating sourcesVirginia HospitalWood stove useLogistic regressionTelephone interviewsMultivariate modelAdditional childrenIntermittent useCare